A5070924300- Complement system in diseases
- Platelet Disorders and Treatments
- Blood Coagulation and Thrombosis Mechanisms
- Sepsis Diagnosis and Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Neuropeptides and Animal Physiology
- Cardiac Arrest and Resuscitation
- Venous Thromboembolism Diagnosis and Management
- Heparin-Induced Thrombocytopenia and Thrombosis
- Liver Disease and Transplantation
- Blood groups and transfusion
- Renal Diseases and Glomerulopathies
- Cell Adhesion Molecules Research
- Lung Cancer Treatments and Mutations
- Blood properties and coagulation
- Trauma and Emergency Care Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Autoimmune Bullous Skin Diseases
- Venomous Animal Envenomation and Studies
- Pancreatitis Pathology and Treatment
- Disaster Response and Management
- Cancer, Hypoxia, and Metabolism
- Neuroinflammation and Neurodegeneration Mechanisms
- Vasculitis and related conditions
- Cancer, Stress, Anesthesia, and Immune Response
Nara Medical University
2014-2024
Nara City Hospital
2023-2024
Nara Medical University Hospital
2014-2023
General Department of Preventive Medicine
2013-2022
National Archives and Records Administration
2013
Teikyo University
2009-2010
Nagoya University
2007-2009
Academy of Emergency Medicine and Care
2000-2007
Pediatrics and Genetics
2006
Baylor College of Medicine
2005
ADAMTS13 consists of a reprolysin-type metalloprotease domain followed by disintegrin domain, thrombospondin type 1 motif (TSP1), Cys-rich and spacer domains, seven more TSP1 motifs, two CUB domains. limits platelet accumulation in microvascular thrombi cleaving the Tyr1605-Met1606 bond von Willebrand factor, deficiency causes lethal syndrome, thrombotic thrombocytopenic purpura. domains required for substrate recognition were localized characterization recombinant deletion mutants....
Objective To investigate plasma concentrations of adrenomedullin in patients with septic shock and the potential association these relaxation vascular tone. Design Prospective, case series. Setting Department Emergency Critical Care Medicine, Nara Medical University. Patients Twelve who fulfilled clinical criteria for severe sepsis or (as defined by Members American College Chest Physicians/Society Medicine Consensus Conference Committee) 13 healthy volunteers. Interventions Arterial blood...
We measured the plasma levels of adrenomedullin (AM), a novel vasodilating peptide, in 89 patients with various forms systemic inflammatory response syndrome (SIRS) and 13 healthy volunteers serving as controls. Plasma AM SIRS (burns: 20.5 ± 3.2 fmol/ml [mean SEM]; pancreatitis: 13.8 3.8 fmol/ml; trauma: 14.9 2.5 traumatic shock: 41.1 7.8 severe sepsis: 59.9 11.2 septic 193.5 30.1 fmol/ml) were significantly increased over those controls (5.1 0.2 fmol/ml). The shock or especially had higher...
von Willebrand factor (vWF) is a multimeric plasma glycoprotein with three tandem A domains. Domains A1 and A3 bind to platelet Ibα (GPIbα) collagen, respectively. Domain A2 contains the Tyr-1605–Met-1606 bond that cleaved by metalloprotease ADAMTS13, this reaction inhibits thrombus growth. Fluid shear stress increases rate of cleavage, suggesting productive interaction ADAMTS13 requires conformational changes within or near domain A2. The influence adjacent domains was assessed mutagenesis...
Background Current guidelines for cardiopulmonary resuscitation (CPR) emphasise that emergency medical service (EMS) dispatchers should identify sudden cardiac arrest (CA) with abnormal breathing and assist lay rescuers performing CPR. However, description of may be inconsistent, it is unclear how EMS provide instruction CPR based on the status CA victims described by laypersons. Methods results To investigate incidence association between dispatcher-assisted layperson CPR, we...
The complete amino acid sequence and location of the disulfide bonds two-chain botrocetin, which promotes platelet agglutination in presence von Willebrand factor, from venom snake Bothrops jararaca are presented. Sequences alpha beta subunits were determined by analysis peptides generated digestion S-pyridylethylated protein with Achromobacter protease I or alpha-chymotrypsin chemical cleavage cyanogen bromide 2-(2'-nitrophenylsulfenyl)-3-methyl-3-bromoindolenine. Two-chain botrocetin is a...
Our objective was to investigate the plasma levels of brain and atrial natriuretic peptides (BNP ANP, respectively) in patients with septic shock/severe sepsis study association BNP ANP hemodynamic parameters, severity disease, prognosis those patients. This is a prospective case series 22 shock, 11 severe sepsis, 20 healthy volunteers at Department Emergency Critical Care Medicine, Nara Medical University Hospital, Japan. Blood collection performed on admission days 1, 2, 4. Plasma were...
Bitiscetin, a platelet adhesion inducer isolated from venom of the snake Bitis arietans, activates binding von Willebrand factor (VWF) A1 domain to glycoprotein Ib (GPIb) in vitro. This activation requires formation bitiscetin-VWF complex, suggesting an allosteric mechanism action. Here, we report crystal structure complex solved at 2.85 Å. In structure, helix α5 VWF lies on concave depression bitiscetin, and sites are located both ends depression. The correspond well with those proposed...
Von Willebrand factor (VWF)–cleaving protease (ADAMTS13) cleaves ultralarge VWF (ULVWF) secreted from endothelium and by which is regulating its physiologic function. An imbalance between ULVWF secretion ADAMTS13 level occurs in sepsis may cause multiple organ dysfunction. We evaluated the association VWF-propeptide (VWF-pp)/ADAMTS13 ratio disease severity patients with severe or septic shock. In 27 shock platelet count less than 120 000/μL, we measured plasma VWF, VWF-pp, levels on hospital...
<i>Background and Purpose:</i> Very few reports are available on changes in the human hippocampus after cardiac arrest. The objective of this study was to investigate if specific hippocampal volume losses can be demonstrated brain following reperfusion <i>Methods:</i> We assessed volumes formation (HF) temporal lobe excluding HF (TL) as contrast using magnetic resonance (MR)-imaging-based volumetry 11 vegetative patients arrest 22 healthy controls similar age, sex...
We examined hepatocellular carcinoma mortality in relation to coffee consumption and anti-hepatitis C virus (HCV) antibody seropositivity a nested case–control study involving 96 cases. The multivariate-adjusted odds ratios (95% confidence interval) for daily drinkers vs non-drinkers were 0.49 (0.25–0.96), 0.31 (0.11–0.85), 0.75 (0.29–1.92) all cases, HCV-positive HCV-negative individuals, respectively.
Passive body heating in controlled settings could shorten sleep onset latency (SOL). The hypothesized mechanism is vasodilation-induced heat loss before bedtime. However, this evidence based on small sample-sized studies specific populations. Thus, we analyzed the association of hot-water bathing and its before-bedtime timing with SOL a large study population older adults.We conducted longitudinal analysis using repeated measurements among 1,094 adults (mean age, 72.0 years). was recorded...
Abstract Caplacizumab is an anti-von Willebrand factor humanized single-variable-domain immunoglobulin fragment whose efficacy and safety in immune-mediated thrombotic thrombocytopenia purpura (iTTP) have been demonstrated international studies. This prospective, open-label phase 2/3 study evaluated caplacizumab 10 mg administered daily during plasma exchange for 30 days afterward, combination with immunosuppressive treatment, Japanese adults a clinical diagnosis of iTTP (new or recurrent)....
Abstract Background The functional dynamics of coagulation and fibrinolysis in patients with disseminated intravascular (DIC) vary due to the pathology severity various underlying diseases. Conventional measurements hemostasis such as thrombin–antithrombin complex, plasmin-α2-plasmin-inhibitor fibrinogen-fibrin degradation products may not always reflect critical pathophysiologic mechanisms DIC. This article aims clarify sepsis-associated DIC using assessment comprehensive fibrinolysis....