A5078914737- Carbohydrate Chemistry and Synthesis
- Helicobacter pylori-related gastroenterology studies
- Glycosylation and Glycoproteins Research
- Gastric Cancer Management and Outcomes
- Lysosomal Storage Disorders Research
- Gastroesophageal reflux and treatments
- Esophageal Cancer Research and Treatment
- Eosinophilic Esophagitis
- Enzyme Production and Characterization
- Esophageal and GI Pathology
- Dynamics and Control of Mechanical Systems
- Structural Health Monitoring Techniques
- Contact Mechanics and Variational Inequalities
- Topology Optimization in Engineering
- Gastrointestinal Tumor Research and Treatment
- Vibration and Dynamic Analysis
- Microbial Natural Products and Biosynthesis
- Metastasis and carcinoma case studies
- Composite Structure Analysis and Optimization
- Microbial Metabolites in Food Biotechnology
- Fuel Cells and Related Materials
- Digestive system and related health
- Trypanosoma species research and implications
- Numerical methods in engineering
- Adhesion, Friction, and Surface Interactions
Miyagi Prefectural Hospital Organization
2024-2025
Tohoku University
2016-2025
Dokkyo Medical University Saitama Medical Center
2017-2025
Social Insurance Saitama Chuo Hospital
2018-2025
Tohoku Medical Megabank Organization
2023
Tohoku University Hospital
2012-2021
Dokkyo Medical University
2018-2019
Nagano Prefectural Suzaka Hospital
2019
Kindai University
2018
Nagoya Municipal Industrial Research Institute
2018
To produce a proton conductive and durable polymer electrolyte membrane for fuel cell applications, series of sulfonated polyimide ionomers containing aliphatic groups both in the main side chains have been synthesized. The title 1 with ion exchange capacity 1.78−2.33 mequiv/g were obtained by typical polycondensation reaction as transparent, ductile, flexible membranes. conductivity was slightly lower than that perfluorinated ionomer (Nafion) below 100 °C, but comparable at higher...
Various kinds of N-substituted valiolamine derivatives, including compounds 23a, 24a, and 34a, which are structurally analogous to the key pseudodisaccharides (25a 26a) naturally occurring oligosaccharide alpha-D-glucosidase inhibitors, have been synthesized estimated by measure inhibitory activity against porcine sucrase maltase. The derivatives evaluated in this study found be more potent than corresponding valienamine as well parent valiolamine. It is noteworthy that even simple such...
The mechanisms underlying the susceptibility of individuals with caspase recruitment domain 15 (CARD15) mutations and corresponding abnormalities nucleotide-binding oligomerization 2 (NOD2) protein to Crohn disease are still poorly understood. One possibility is based on previous studies showing that muramyl dipeptide (MDP) activation NOD2 negatively regulates TLR2 responses absence such regulation leads heightened Th1 responses. We now report administration MDP protects mice from...
New polyhydroxylated alkaloids, (2R,3R,4R)-2-hydroxymethyl-3,4-dihydroxypyrrolidine-N-propionamide from the root bark of Morus alba L., and 4-O-alpha-D-galactopyranosyl-calystegine B(2) 3 beta,6 beta-dihydroxynortropane fruits, were isolated by column chromatography using a variety ion-exchange resins. Fifteen other alkaloids also isolated. 1-Deoxynojirimycin, potent alpha-glucosidase inhibitor, was concentrated 2.7-fold silkworms feeding on mulberry leaves. Some contained in leaves...
Nucleotide-binding oligomerization domain 1 (NOD1) is an intracellular epithelial cell protein known to play a role in host defense at mucosal surfaces. Here we show that ligand specific for NOD1, peptide derived from peptidoglycan, initiates unexpected signaling pathway human lines results the production of type I IFN. Detailed analysis revealed components pathway. NOD1 binding its triggered activation serine-threonine kinase RICK, which was then able bind TNF receptor-associated factor 3...
Fabry disease is a lysosomal storage disorder caused by deficient alpha-galactosidase A (alpha-Gal A) activity. Deficiency of the enzyme activity results in progressive deposition neutral glycosphingolipids with terminal alpha-galactosyl residue vascular endothelial cells. We recently proposed chemical chaperone therapy for this administration 1-deoxygalactonojirimycin, potent inhibitor enzyme, at subinhibitory intracellular concentrations [Fan, J.-Q., Ishii, S., Asano, N. and Suzuki, Y....
l-Enantiomers of 1-deoxynojirimycin (DNJ), 1-deoxymannojirimycin (manno-DNJ), 1-deoxyallonojirimycin (allo-DNJ), 1-deoxyaltronojirimycin (altro-DNJ), 1-deoxygalactonojirimycin (galacto-DNJ), 1-deoxygulonojirimycin (gulo-DNJ), and 1-deoxyidonojirimycin (ido-DNJ) were prepared according to prior methods for the d-enantiomers. These enantiospecific syntheses established unambiguously absolute configuration naturally occurring DNJ, manno-DNJ, allo-DNJ, altro-DNJ, gulo-DNJ. Although d-DNJ...
Remove to improve. Removal of the hydroxymethyl groups in 1 give 2 significantly enhances inhibitory potency towards glucosylceramide β-glucosidase (GCase) and abolishes inhibition α-glucosidases. Xylitol doubles residual activity GCase fibroblasts from Gaucher patients at subinhibitory concentration (10 nM). This compound is therefore a promising candidate for development small-molecule drugs treatment Gaucher's disease without side effects associated with α-glucosidase inhibition.
We have recently identified that rat organic anion transporters, polypeptide2 (oatp2) and oatp3, both of which transport thyroid hormones. However, in humans the molecular organization transporters has diverged, responsible molecule for hormone not been clarified, except human liver-specific transporter (LST-1) by us. In this study we isolated characterized a novel transporter, OATP-E from brain. The complementary DNA encodes polypeptide 722 amino acids with 12 transmembrane domains. A...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNitrogen-in-the-Ring Pyranoses and Furanoses: Structural Basis of Inhibition Mammalian GlycosidasesNaoki Asano, Kengo Oseki, Haruhisa Kizu, Katsuhiko MatsuiCite this: J. Med. Chem. 1994, 37, 22, 3701–3706Publication Date (Print):October 1, 1994Publication History Published online1 May 2002Published inissue 1 October 1994https://pubs.acs.org/doi/10.1021/jm00048a006https://doi.org/10.1021/jm00048a006research-articleACS PublicationsRequest reuse...
Novel sulfonated polyimide ionomer-containing aliphatic groups both in the main chain and side chains exhibit high proton conductivity of 0.2 S cm-1 at 140 °C without being hydrolyzed for more than several hundred hours under severe humidified conditions.
The aqueous MeOH extract of the leaves and root Xanthocercis zambesiaca (Leguminosae) eight structurally related nitrogen-containing sugars, fagomine (1), 4-O-beta-D-glucopyranosylfagomine (2), 3-O-beta-D-glucopyranosylfagomine (3), 3-epifagomine (4), 2,5-dideoxy-2,5-imino-D-mannitol (5), castanospermine (6), alpha-homonojirimycin (7), 1-deoxynojirimycin (8) were evaluated for antihyperglycemic effects in streptozotocin (STZ)-diabetic mice. insulin-releasing 1 also investigated. blood...
Natural intoxication of livestock by the ingestion Ipomoea carnea (Convolvulaceae) sometimes occurs in tropical regions world. Polyhydroxylated alkaloids were isolated from leaves, flowers, and seeds poisonous plant characterized. Chromatographic separation leaf extract resulted isolation swainsonine (1), 2-epi-lentiginosine (2), calystegines B1 (3), B2 (4), B3 (5), C1 (6), N-methyl-trans-4-hydroxy-l-proline (7). The contents 1 fresh leaves flowers 0.0029 0.0028%, respectively, whereas 1, 3,...