A5078176734- Cardiac Arrhythmias and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Cardiac pacing and defibrillation studies
- Cardiovascular Function and Risk Factors
- Cancer Research and Treatments
- Heart Failure Treatment and Management
- 3D Printing in Biomedical Research
- Cardiac Imaging and Diagnostics
- Nanoplatforms for cancer theranostics
- Advanced biosensing and bioanalysis techniques
- Education and Professional Development
- Diabetes Treatment and Management
- Health and Well-being Studies
- Fluorine in Organic Chemistry
- RNA Interference and Gene Delivery
- Psychology of Development and Education
- Advanced MRI Techniques and Applications
- Evolutionary Psychology and Human Behavior
- Nutrition and Health in Aging
- Enzyme Production and Characterization
- Face Recognition and Perception
- Innovative Microfluidic and Catalytic Techniques Innovation
- Phosphorus compounds and reactions
- Synthesis and Reactions of Organic Compounds
Kobe University
2019-2025
Kobe Gakuin University
2011-2025
Oita University
2010-2024
Yazaki (United States)
2024
The University of Tokyo
2015-2023
North Medical Center
2023
Hiroshima City Asa Citizens Hospital
2023
Mie Chuo Medical Center
2023
Mie University
2006-2022
Osaka Prefectural Medical Center
2019-2021
Abstract Fluorescence-guided diagnostics is one of the most promising approaches for facile detection cancer in situ . Here we focus on β-galactosidase, which overexpressed primary ovarian cancers, as a molecular target visualizing peritoneal metastases from cancers. As existing fluorescence probes are unsuitable, have designed membrane-permeable HMRef-βGal, optimized intramolecular spirocyclic function affords >1,400-fold enhancement activation. We confirm that HMRef-βGal sensitively...
Prostate cancer (PCa) is a common malignant tumor among adult males, and convenient intraoperative detection of PCa would reduce the risk leaving positive surgical margins, especially during nerve-sparing procedures. To achieve rapid, fluorescence-based visualization PCa, we focused on glutamate carboxypeptidase (CP) activity prostate-specific membrane antigen (PSMA), type II transmembrane glycoprotein that attracting attention as biomarker. Based our finding aryl conjugates with an...
Background: Empagliflozin reduces the risk of hospitalization for heart failure in patients with type 2 diabetes and cardiovascular disease. We sought to elucidate effect empagliflozin as an add-on therapy on decongestion renal function admitted acute decompensated failure. Methods: The study was terminated early due COVID-19 pandemic. enrolled 59 consecutive Patients were randomly assigned receive either (n=30) or conventional glucose-lowering (n=29). performed laboratory tests at baseline...
PURPOSE: To evaluate the use of blueberry juice as an oral contrast agent in magnetic resonance (MR) imaging. MATERIALS AND METHODS: MR imaging phantoms and manganese chloride solutions with different concentrations were conducted. Patient trials conducted to blood levels signal intensity changes on images abdomen. T1- T2-weighted conventional spin-echo was performed at various field strengths. Six radiologists graded image contrast; intensities calculated. RESULTS: T1 T2 relaxation curves...
The effects of aminoglycoside antibiotics on cellular functions the LLC-PK1 kidney epithelial cell line were studied as a model system for nephrotoxicity. treatment with 3 days caused decrease in dome number confluent cells and an increase floating culture medium. inhibition formation was dose-dependent rank-order degree compatible vivo Aminoglycosides also decreased intracellular content cyclic AMP, correlation between alteration AMP content. specific activities...
Recent advances in three-/four-dimensional (3D/4D) ultrasound, such as HDlive Flow, provide the potential to evaluate more precisely fetal and placental circulations1-5 gynecological disorders6-10. Flow silhouette mode is latest technology demonstrate blood flow with vitreous-like clarity. This technique has ability delineate vessel walls, while presenting lumen semitransparent. We present our experience of imaging normal abnormal cardiac structures, reconstructed using spatiotemporal image...
Five-aminolevulinic acid (5-ALA) is widely used as an intraoperative fluorescent probe for radical resection of high-grade glioma, and thus aids in extending progression-free survival patients. However, there exist some cases where 5-ALA fails to fluoresce. In other cases, it may undergo fluorescence quenching but cannot be orally readministered during surgery. This study aimed develop a novel hydroxymethyl rhodamine green (HMRG)-based labeling system that can repeatedly administered topical...
Prenylation of the aromatic intermediate p-hydroxybenzoate (PHB) is a critical step in ubiquinone (UQ) biosynthesis. The enzyme that catalyzes this prenylation reaction polyprenyltransferase (PPT), which substitutes an proton at m-position PHB with prenyl chain provided by polyprenyl diphosphate synthase. rice genome contains three PPT candidates share significant similarity yeast (COQ2 gene), and gene showing highest to COQ2 was isolated reverse transcription–PCR designated OsPPT1a. deduced...
Abstract The areas with electrically fractionated potentials (AEFP) during sinus rhythm are related to non-pulmonary vein triggers and may serve as substrates of atrial fibrillation (AF) maintenance. However, the histological properties these compounds remain unclear. Therefore, we aimed evaluate late gadolinium enhancement (LGE) AEFP in patients AF. We enrolled 15 AF who had undergone LGE magnetic resonance imaging before catheter ablation. left atrium was detected using HD-Grid NavX...
Abstract Background Cryoballoon ablation (CBA) is useful for pulmonary vein (PV) isolation. However, some cases are challenging, requiring multiple applications and/or touch‐up ablations. Although several predictors of CBA difficulty have been reported, none assessed the spatial location and morphology left atrium PVs. This study aimed to develop a three‐dimensional (3D) deep learning (DL) model predict compare its accuracy with conventional manual measurement. Methods A 28‐mm cryoballoon...
Abstract One function of Alzheimer amyloid protein precursor (APP) is the regulation growth and differentiation in several types cells, including fibroblasts, PC12 neurons. This activity represented by a small stretch amino acids center molecule around RERMS. The APP 17‐mer peptide containing RERMS domain supported survival neurite extension rat cortical neurons dose‐dependent sequence‐specific manner. fragment synthesized Escherichia coli neurons, whereas mutant lacking 30 had drastically...
Construction of capillary networks is a fundamental challenge for the development three-dimensional (3D) tissue engineering. However, it not well understood how to construct stable that maintain luminal size similar structures in vivo (i.e., <10 μm diameter). In this study, we demonstrated construction covered by pericyte-like perivascular cells using an vitro 3D angiogenesis model optimizing interactions between endothelial and cells. Our can be combined with culture epithelial context...
We present a detailed study on the classification of ZnS quantum dots (QDs) by size selective precipitation (SSP). SSP allows postsynthetic narrowing given feed distribution and is usually realized titration poor solvent into suspension dispersed particles. Thereby preferred flocculation larger structures induced. Our results confirm that highly robust process, following law mass action. That means certain composition always leads to same ratio between coarse fines particles with respect...
Background The Kidney Disease: Improving Global Outcomes chronic kidney disease (CKD) guidelines recommend that CKD be classified based on the etiology, glomerular filtration rate (GFR) and degree of albuminuria. present study aimed to establish a method predicts presence microalbuminuria by measuring total urine protein-to-creatinine ratio (TPCR) in patients with cardiovascular (CVD) risk factors. Methods Results We obtained samples from 1,033 who visited clinic at St. Luke's International...