A5072963397- Dialysis and Renal Disease Management
- Pharmacological Effects of Natural Compounds
- Chronic Kidney Disease and Diabetes
- Natural product bioactivities and synthesis
- Acute Kidney Injury Research
- Erythropoietin and Anemia Treatment
- Electrolyte and hormonal disorders
- Healthcare and Venom Research
- Renal and Vascular Pathologies
- Ginseng Biological Effects and Applications
- Renal Diseases and Glomerulopathies
- Phytochemistry and biological activity of medicinal plants
- Potassium and Related Disorders
- Hemoglobinopathies and Related Disorders
- Traditional Chinese Medicine Analysis
- Herbal Medicine Research Studies
- Iron Metabolism and Disorders
- Mangiferin and Mango Extracts
- Natural Antidiabetic Agents Studies
- Bipolar Disorder and Treatment
- Health Systems, Economic Evaluations, Quality of Life
- Renal function and acid-base balance
- Cancer Treatment and Pharmacology
- Phytochemicals and Antioxidant Activities
- Plant-based Medicinal Research
Gunma University
2018-2025
Mie Chuo Medical Center
2025
St. Luke's International Hospital
2014-2024
Toho University
2023-2024
Okayama University
2020-2022
Keihin (Japan)
2019
Japanese Society of Nephrology
2019
Japanese Society for Dialysis Therapy
2015-2017
Jikei University School of Medicine
1995-2017
Kitasato University
2014-2016
Rationale & ObjectiveEpidemiologic and clinical studies have suggested that urate-lowering therapy may slow the progression of chronic kidney disease (CKD). However, definitive evidence is lacking.Study DesignRandomized, double-blind, placebo-controlled trial.Setting Participants467 patients with stage 3 CKD asymptomatic hyperuricemia at 55 medical institutions in Japan.InterventionParticipants were randomly assigned a 1:1 ratio to receive febuxostat or placebo for 108 weeks.OutcomesThe...
Abstract The Japanese Society for Dialysis Therapy (JSDT) guideline committee, chaired by Dr Y. Tsubakihara, presents the guidelines entitled “Guidelines Renal Anemia in Chronic Kidney Disease.” These replace “2004 JSDT Guidelines Hemodialysis Patients,” and contain new, additional peritoneal dialysis (PD), non‐dialysis (ND), pediatric chronic kidney disease (CKD) patients. Chapter 1 reference values diagnosing anemia that are based on most recent epidemiological data from general...
Renal anemia is a complication of chronic kidney disease. Guidelines for safe and effective treatment in patients with renal are needed. The Japanese Society Dialysis Therapy (JSDT) published guidelines the hemodialysis 2004 hemodialysis, peritoneal dialysis, predialysis, pediatric 2008. These two publications provide excellent guidance respect to clinical practice issues, including definition diagnosis anemia, criteria initiation treatment, target hemoglobin levels, iron supplementation...
In recent years, a concept of renal rehabilitation has become widely known among nephrology specialists, dialysis kidney transplantation nutrition guideline nurses, physiotherapists, and representatives patients. Therefore, in order to make it clear the definition, methods, effectiveness Japan, we launched Renal Rehabilitation Guideline Preparation Committee 2016 as part works Japanese Society Rehabilitation, created accordance "Minds Handbook for Clinical Practice Development 2014". Here,...
Background Chronic kidney disease is an important concern in preventive medicine, but the rate of decline renal function healthy population not well defined. The purpose this study was to determine reference values for estimated glomerular filtration (eGFR) and eGFR subjects evaluate factors associated with using a large cohort Japan. Methods Retrospective cross-sectional longitudinal studies were performed aged ≥18 years old who received medical checkup. Reference obtained nonparametric...
The Japanese Society for Dialysis Therapy (JSDT) has published Clinical Guidelines Maintenance Hemodialysis: Hemodialysis Prescription. These evidence-based guidelines focus on the characteristics of dialysis performed in Japan. number elderly patients undergoing long-term hemodialysis (HD) is higher Japan than other countries. purpose to provide recommendation long-term, stable HD. main body shows current recommended minimal standards HD (i.e. at a blood flow rate least 200 mL/min using an...
Standard care for treating anemia in patients with CKD includes use of erythropoiesis-stimulating agents, which sometimes involves increased risks cardiovascular morbidity and mortality. Previous studies nondialysis-dependent (NDD-CKD) found significantly elevated hemoglobin levels vadadustat, an oral hypoxia-inducible factor prolyl hydroxylase inhibitor, compared placebo.In this phase 3, open-label, active-controlled noninferiority trial, we randomized 304 Japanese adults NDD-CKD (including...
Mangiferin (MF) and its glucosides (mangiferin-7-O-β-glucoside) (MG) isolated from Anemarrhena asphodeloides Bunge rhizome, were tested for their antidiabetic activity in KK-Ay mice, an animal model of non-insulin-dependent diabetes mellitus (NIDDM). MF MG lowered the blood glucose level mice after oral administration. However, no affect on normal was seen, indicating that are useful treating NIDDM. In addition, or improved hyperinsulinemia mice. From these findings, it seems likely exert by...
Five new maleic and succinic acid derivatives were isolated from the mycelium of Antrodia camphorata. Their structures determined by various spectroscopic means. Maleimide 2 3 showed appreciable cytotoxic activity against LLC cells.
In Japan, guidelines for initiation of chronic hemodialysis (Health Science Research Guidelines 1), prepared by the Committee Medical Project Kidney Failure set up Japanese Ministry Welfare in 1991, have been used as a criteria dialysis more than 20 years. Though this guideline is still utilized clinical field, current characteristics patients largely changed compared to those days. Currently, mean age 65 years, and with systemic vascular complications derived diabetic nephropathy or...
Vadadustat is an oral hypoxia-inducible factor prolyl hydroxylase inhibitor that stimulates erythropoiesis.The efficacy and safety of vadadustat, compared with darbepoetin alfa, was determined in a Phase 3 double-blind study Japanese anemic patients on hemodialysis. Patients receiving erythropoiesis-stimulating agents (ESAs) were randomized switched to either vadadustat or alfa for 52 weeks. Doses adjusted maintain hemoglobin (Hb) level 10.0-12.0 g/dL. The primary endpoint average Hb at...
Posttransplant recurrence is frequent in patients who received renal transplantation for focal segmental glomerulosclerosis (FSGS). The has been ascribed to a circulating permeability factor or factors. We have used plasmapheresis (PP) treat recurrent FSGS and also studied whether preoperative PP effective preventing of FSGS.We retrospectively analyzed 21 allografts 20 with nephrotic syndrome biopsyproven FSGS. They were divided into two groups depending on they had prophylactic PP; (n=15)...
Abstract Background Only a few approved drugs are capable of alleviating the cognitive and behavioural symptoms people living with A lzheimer's disease ( AD ). In recent years, however, number studies examining clinical effects herbal medicines on function in patients has increased considerably. This study evaluated long‐term traditional Japanese medicine K ampo medicine) known as ninjin'yoeito NYT ) impairment mood status over 2‐year period. Methods Twenty‐three mild‐to‐moderate probable...
We have investigated the inhibitory effect of oral administration Juzen‐taiho‐to , a Kampo Japanese herbal medicine, on liver metastasis by inoculation liver‐metastatic variant (L5) murine colon 26 carcinoma cells into portal vein. Oral for 7 days before tumor resulted in dose‐dependent inhibition colonies and significant enhancement survival rate as compared with untreated control, without side effects. also found that L5 was enhanced BALB/c mice pretreated anti‐asialo GM1 serum or...
The water-soluble extract from a Paraguayan natural medicine, Nangapiry, the leaves of Eugenia uniflora L. (Myrtaceae), which has been used as an antidiabetic agent, was found to show inhibitory activities on increase plasma glucose level in sucrose tolerance test (STT) conducted with mice. portion adsorbed cation exchange resin also inhibit a-glucosidases. From active portion, two new compounds named uniflorines A ( 1 ) and B 2 known (+)-(3a, 4a, 5ß)-1-methylpiperidine-3, 4, 5-triol 3 were...
The authors previously reported that transforming growth factor beta1 (TGF-beta1) induces apoptosis in McA-RH7777 (7777) and McA-RH8994 (8994) rat hepatoma cell lines. Although these lines exhibit different responses to glucocorticoid treatment various cellular functions gene expression, dexamethasone (DEX) inhibited spontaneous TGF-beta1-induced both. Analysis of analogous hormones 8994 cells suggested the inhibitory effect be glucocorticoid-specific. By cell-cycle analysis DNA...
Transforming growth factor beta 1 (TGF-beta 1) is reported to play an important role in the induction of liver cell apoptosis. In this report, we demonstrate that TGF-beta induces apoptosis a rat Morris hepatoma McA-RH8994 line and primary cultured hepatocytes at similar doses manner. Using cells, screened number chemical reagents, aqueous extracts crude drugs, herbal medicines for their inhibitory activities on 1-induced The results indicate Artemisiae capillaris spica (ACS) ACS-containing...