A5100716566- Renal Diseases and Glomerulopathies
- Renal and related cancers
- Chronic Kidney Disease and Diabetes
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Vasculitis and related conditions
- Genetic and Kidney Cyst Diseases
- IgG4-Related and Inflammatory Diseases
- Asthma and respiratory diseases
- Renal Transplantation Outcomes and Treatments
- Systemic Lupus Erythematosus Research
- Pediatric Urology and Nephrology Studies
- Renal and Vascular Pathologies
- Cell Adhesion Molecules Research
- Urological Disorders and Treatments
- Pancreatic function and diabetes
- Complement system in diseases
- Platelet Disorders and Treatments
- Systemic Sclerosis and Related Diseases
- Monoclonal and Polyclonal Antibodies Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Autoimmune Bullous Skin Diseases
- Gastrointestinal disorders and treatments
- Eosinophilic Disorders and Syndromes
- Pregnancy and Medication Impact
- Immune Cell Function and Interaction
University of Tsukuba
2015-2024
Mie Chuo Medical Center
2022-2024
University of Tsukuba Hospital
2021
Chiba Cancer Center
2005-2011
Saitama Medical University
1999-2010
Nihon University
2004-2008
Tohoku University
2008
Kyorin University
2008
Kyushu University
1994-2008
The University of Tokyo
2005-2008
Abstract CD8+ islet cell-specific CTL lines and clones were established from lymphocytes infiltrating the pancreatic islets of acutely diabetic nonobese (NOD) mice two subcolonies (NOD/Yn NOD/Lt). NOD/Yn predominantly cytotoxic against H-2b+ cells to a lesser extent H-2d+ cells. On other hand, NOD/Lt but not Three four derived H-2Db restricted, whereas H-2Kd restricted. However, all restricted T cell expressed same TCR, regardless NOD subcolony which they derived, compatible with repertoire....
The immunosuppressive activities of a newly discovered macrolide extracted from Streptomyces tsukubaensis, FK506, were examined using 38 renal allografts in the beagle dog. median survival time was 15.5 days dogs without treatment, 61 with dose 0.08 mg/kg/day and 176 0.16 intramuscularly administered FK506. Prolongation statistically significant when compared controls (P = 0.02, 0.0044, respectively). None 6 recipient receiving agent at encountered rejection during treatment course. Three...
Vascular endothelial growth factor (VEGF) is an important mediator in maintaining normal kidney functions. In addition, several lines of evidence suggest that upregulation VEGF glomeruli may be associated with or cause renal dysfunction such as diabetic nephropathy. For elucidation the pathologic consequences high levels glomeruli, transgenic (Tg) rabbits express human VEGF(165) isoform both and liver under control alpha-1-antitrypsin promoter were generated characterized. With use...
Mammals have two types of full-grown oocytes: those with germinal vesicles (GVs) in which the chromatin is condensed and surrounds nucleolus (surrounded-nucleolus (SN)-type) less does not surround (non-surrounded-nucleolus (NSN)-type). Although SN oocytes possess higher meiotic developmental competence than NSN oocytes, factors underlying this difference are unknown.The GVs murine were exchanged by nuclear transfer nucleus/cytoplasm each reconstructed oocyte was classified as follows: SN/SN,...
Abstract Adhesion to the adhesion protein, VCAM-1, on vascular endothelium is proposed be an important factor in selective accumulation of eosinophils at sites allergic inflammation. To determine whether eosinophil VCAM-1 also associated with alteration function, human peripheral blood were isolated from donors and incubated VCAM-1-coated wells. Spontaneous adherence wells was greater than cells FCS-treated control (38.0 +/- 1.6% vs 17.1 1.9%, n = 16, p < 0.0001). In addition,...
Posttransplant recurrence is frequent in patients who received renal transplantation for focal segmental glomerulosclerosis (FSGS). The has been ascribed to a circulating permeability factor or factors. We have used plasmapheresis (PP) treat recurrent FSGS and also studied whether preoperative PP effective preventing of FSGS.We retrospectively analyzed 21 allografts 20 with nephrotic syndrome biopsyproven FSGS. They were divided into two groups depending on they had prophylactic PP; (n=15)...