A5055065654- Renal Diseases and Glomerulopathies
- Monoclonal and Polyclonal Antibodies Research
- T-cell and B-cell Immunology
- Chronic Kidney Disease and Diabetes
- Systemic Lupus Erythematosus Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Platelet Disorders and Treatments
- Immune Cell Function and Interaction
- Heart Rate Variability and Autonomic Control
- Complement system in diseases
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Blood Pressure and Hypertension Studies
- Cell Adhesion Molecules Research
- Vasculitis and related conditions
- Immunodeficiency and Autoimmune Disorders
- Cardiovascular Health and Disease Prevention
- Systemic Sclerosis and Related Diseases
- Celiac Disease Research and Management
- Diabetes and associated disorders
- Mycobacterium research and diagnosis
- Autoimmune Bullous Skin Diseases
- Cancer, Hypoxia, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Blood groups and transfusion
- Acute Kidney Injury Research
University of Fukui
2005-2020
Akita University
2017
University of Fukui Hospital
2006
Kyoto University
1987-2005
Nippon Shinyaku (Japan)
1988-2005
Kitano Hospital
1996-2005
Himeji Medical Center
1989-2005
Niigata University
2000-2003
Kyoto City Hospital
1999
Shiga Medical Center for Adults
1999
The effect of the autosomal mutant gene lpr (lymphoproliferation) on development various autoantibodies and immune complex (IC) glomerulonephritis was investigated in four genetically distinct strains mice: MRL/ MpJ , C3H/HeJ, C57BL/6J, AKR/J. presence not only enhanced production autoimmune strain, but also induced formation kinds three other mice without any apparent predisposition to disease. Autoantibodies by included anti-double-stranded DNA, anti-single-stranded anti-IgG,...
Meditation is a specific consciousness state in which deep relaxation and increased internalized attention coexist. There have been various neurophysiological studies on meditation. However, the personal predispositions/traits that characterize properties of meditation not adequately studied. We analyzed changes parameters [EEG coherence autonomic nervous activity using heart rate variability (HRV) as an index] during Zen meditation, evaluated results association with trait anxiety (assessed...
Abstract Because abnormalities of mucosal immunity have been suggested in human IgA nephropathy, we examined the involvement deposition to kidney hyper (HIGA) mice, which was established as a mouse model for nephropathy with hyperserum IgA. The number surface IgA+B220− lymphocytes intestinal lamina propria (LP) HIGA mice increased 2.7-fold at 30 wk age compared those 10 age, whereas normal did not show such increase. LP spontaneously secreted culture. Morphological studies showed that murine...
Rosmarinic acid is a phenolic compound widely distributed in Labiatae herbs such as rosemary, sweet basil, and perilla, which are frequently used with meat fish dishes Western Asian countries. In the present study we investigated effects of rosmarinic on cultured murine mesangial cell proliferation.Cultured cells were stimulated by growth factors or without acid, [(3)H]thymidine incorporation was measured regard both to signal transduction cycle dependency. other experiments, mRNA extracted...
Clonotypes of IgG anti-DNA antibodies were studied by isoelectric focusing in various autoimmune mice with or without lethal lupus nephritis. MRL/MpJ-lpr/lpr exhibited the most heterogeneous spectrotypes pH range from 6.5 to 8.5, marked variation individual mice. Female (NZB X NZW)F1 expressed rather uniform DNA-binding bands composed at least five six distinct subgroups, having points 8.0. Male BXSB showed major characteristic confined alkaline 7.8 similar C57BL/6J-lpr/lpr mice, which...
Oxidative stress is a major determinant of acute kidney injury (AKI); however, the effects an AKI on renal redox system are unclear, and few existing markers suitable for evaluating oxidative stress. We measured urinary levels redox-regulatory protein thioredoxin 1 (TRX1) in patients with various kinds disease mice ischemia-reperfusion injury. Urinary TRX1 were markedly higher than those chronic or healthy subjects. In receiver operating characteristic curve analysis to differentiate between...
Low-density lipoprotein apheresis (LDL-A) was performed for nine episodes of steroid-resistant nephrotic syndrome in eight patients. The clinical and immunohistological findings were analysed retrospectively. Six the patients had focal glomerular sclerosis (FGS), one minimal-change (MCNS), membranous nephropathy (MN) with FGS. LDL-A treatment, carried out 2–13 times (mean 7.33±4.05) episode, at average intervals 3–16 days (mean: 8.5 ±5.1 days) combined steroid pulse therapy administration an...
An outbred mouse strain known as ddY has been reported to spontaneously develop, late in life, mesangioproliferative glomerulonephritis with a severe glomerular immunoglobulin A (IgA) deposition that mimics human IgA nephropathy. However, the incidence of disease this is not very high, probably due its heterogeneous genetic background. Therefore, we attempted isolate high and an early onset through selection for serum from mice. The procedure was successful increasing level selected line...
We have previously raised an anti-c-erb A peptide antibody (designated 4B II) which immunoprecipitated in vitro transcription/translation products of c-erb alpha 1 and beta. II could recognize nuclear T3 receptor (NT3R) without distinction between difference species tissues. Using II, we studied immunohistochemical localization NT3R proteins various tissues the rat. Cryostat sections (4-6 microns) selected rat were incubated with at 4C overnight, followed by...
Aβ2M (β2-microglobulin-related) amyloidosis is a frequent and serious complication in patients on long-term dialysis. Partial unfolding of β2-m (β2-microglobulin) may be essential to its assembly into amyloid fibrils vivo. Although SDS around the critical micelle concentration induces partial an α-helix-containing aggregation-prone amyloidogenic conformer subsequent fibril formation vitro, biological molecules with similar activity under near-physiological conditions are still unknown. The...
Background. In β 2 -microglobulin-related (Aβ2M) amyloidosis, partial unfolding of -microglobulin (β2-m) is believed to be prerequisite its assembly into Aβ2M amyloid fibrils in vivo . Low concentrations sodium dodecyl sulfate induce β2-m an amyloidogenic conformer and subsequent fibril formation vitro , but the biological molecules that them under near-physiological conditions have not been determined.
Background. Peroxisome proliferator-activated receptor (PPAR)-γ may counteract tissue fibrosis via its anti-inflammatory actions, while hypoxia, a new pro-fibrotic factor, reportedly modifies PPAR-γ expression. However, the effects of hypoxia on expression and actions have yet remained to be clarified in renal tubular cells.
ABSTRACT Early detection of tuberculosis (TB) is essential for infection control. The geneCube (Toyobo) a novel fully automated gene analyzer that can amplify target DNAs within 60 min. In this study, we evaluated the ability to directly detect Mycobacterium complex (MTBC) and avium (MAC) in clinical specimens. results were then compared with those obtained using conventional culture, microscopy, Cobas Amplicor assay (Roche). We examined total 516 frozen samples from 69 patients who showed...