- Analytical chemistry methods development
- Metal complexes synthesis and properties
- Microbial Natural Products and Biosynthesis
- Mass Spectrometry Techniques and Applications
- Blood disorders and treatments
- Immunodeficiency and Autoimmune Disorders
- Dialysis and Renal Disease Management
- Chemical Synthesis and Analysis
- Electrochemical Analysis and Applications
- Magnetism in coordination complexes
- X-ray Diffraction in Crystallography
- Renal Diseases and Glomerulopathies
- Crystal structures of chemical compounds
- Ion-surface interactions and analysis
- Metal-Catalyzed Oxygenation Mechanisms
- Cancer therapeutics and mechanisms
- Neutropenia and Cancer Infections
- Crystallization and Solubility Studies
- Analytical Chemistry and Chromatography
- Osteoarthritis Treatment and Mechanisms
- Carbohydrate Chemistry and Synthesis
- Antibiotic Resistance in Bacteria
- Renal Transplantation Outcomes and Treatments
- Antibiotics Pharmacokinetics and Efficacy
- Asthma and respiratory diseases
Hiroshima University Hospital
2002-2025
Nadogaya Hospital
2024-2025
Tokyo Medical Center
2022-2025
Hiroshima University
2013-2023
Aichi Gakuin University
2023
Jyoban Hospital
2014-2022
Osaka City University
1969-2022
Osaka City University Hospital
2022
Pediatric Nephrology of Alabama
2018
Sumitomo Heavy Industries (Japan)
2018
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEsperamicins, a novel class of potent antitumor antibiotics. 3. Structures esperamicins A1, A2, and A1bJerzy Golik, George Dubay, Gary Groenewold, Hiroshi Kawaguchi, Masataka Konishi, Bala Krishnan, Hiroaki Ohkuma, Kyoichiro Saitoh, Terrence W. DoyleCite this: J. Am. Chem. Soc. 1987, 109, 11, 3462–3464Publication Date (Print):May 1, 1987Publication History Published online1 May 2002Published inissue 1...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTEsperamicins, a novel class of potent antitumor antibiotics. 2. Structure esperamicin XJerzy Golik, Jon Clardy, George Dubay, Gary Groenewold, Hiroshi Kawaguchi, Masataka Konishi, Bala Krishnan, Hiroaki Ohkuma, Kyoichiro Saitoh, and Terrence W. DoyleCite this: J. Am. Chem. Soc. 1987, 109, 11, 3461–3462Publication Date (Print):May 1, 1987Publication History Published online1 May 2002Published inissue 1...
Despite great efforts to promote the donation of cadaveric organs, number organ transplantations in Japan is not increasing and a serious shortage organs exists. These circumstances have forced widening indications for kidney transplantation. For this purpose, ABO-incompatible living (LKTs) been performed. Although we already reported short-term results LKT, there no report long-term such cases; anti-A anti-B antibodies could cause antibody-induced chronic rejection result poor graft...
The clonal composition of EBV-infected cells was examined in three cases EBV-associated hemophagocytic syndrome by analysis the heterogeneity terminal repetitive sequences EBV genome, indicating monoclonal expansion all cases. Involvement T lymphoid determined situ hybridization using 35S-labeled RNA probes specific for small EBV-encoded nuclear RNAs, EBER1 and EBER2, combination with immunostaining TCR-beta chain, CD45RO, CD20, CD30 CD68 antigens these majority showing EBER transcripts were...
The epithelial-mesenchymal-transition (EMT) is an important step in the invasion and metastasis of cancer. A critical molecular feature this process downregulation E-cadherin expression, which primarily controlled by Snail-related zinc-finger transcription factors. aim study was to evaluate prognostic impact expression EMT-related proteins (E-cadherin Snail) patients with ovarian An immunohistochemical analysis conducted using tissue microarray samples 174 primary tumors 34 metastases...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMultielement preconcentration of trace heavy metals in water by coprecipitation and flotation with indium hydroxide for inductively coupled plasma-atomic emission spectrometryMasataka. Hiraide, Tetsumasa. Ito, Masafumi. Baba, Hiroshi. Kawaguchi, Atsushi. MizuikeCite this: Anal. Chem. 1980, 52, 6, 804–807Publication Date (Print):May 1, 1980Publication History Published online1 May 2002Published inissue 1...
The epithelial-mesenchymal-transition (EMT) is an important step in the invasion and metastasis of cancer. A critical molecular feature this process downregulation E-cadherin expression, which mainly controlled by Snail-related zinc-finger transcription factors (Snail Slug). aim study was to evaluate prognostic impact EMT-related protein (E-cadherin, Snail Slug) expression endometrial cancer.An immunohistochemical analysis conducted using tissue microarray samples 354 primary tumors 30...
G protein-coupled receptor 30 (GPR30) is a 7-transmembrane estrogen that functions alongside traditional receptors to regulate the cellular responses estrogen. Recent studies suggest GPR30 expression associated with poor prognosis, and this due GPR30-mediated transactivation of EGFR in breast cancer. However, biological contribution ovarian cancer remains unclear. The purpose study was elucidate relationships between clinicopathological findings, determine how signaling cascade influences...
Posttransplant recurrence is frequent in patients who received renal transplantation for focal segmental glomerulosclerosis (FSGS). The has been ascribed to a circulating permeability factor or factors. We have used plasmapheresis (PP) treat recurrent FSGS and also studied whether preoperative PP effective preventing of FSGS.We retrospectively analyzed 21 allografts 20 with nephrotic syndrome biopsyproven FSGS. They were divided into two groups depending on they had prophylactic PP; (n=15)...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTMicrowave excitation emission spectrometry. Determination of picogram quantities metals in metalloenzymesHiroshi. Kawaguchi and Bert L. ValleeCite this: Anal. Chem. 1975, 47, 7, 1029–1034Publication Date (Print):June 1, 1975Publication History Published online1 May 2002Published inissue 1 June 1975https://pubs.acs.org/doi/10.1021/ac60357a064https://doi.org/10.1021/ac60357a064research-articleACS PublicationsRequest reuse permissionsArticle...
<b><i>Background:</i></b> Evidence suggests hemodialysis (HD) patients with resistance to erythropoiesis-stimulating agents (ESA) have a higher mortality rate. We investigated the association between ESA responsiveness and in our HD population. <b><i>Methods:</i></b> A prospective cohort study of chronic was conducted at Jyoban Hospital Fukushima, Japan. collected data on patient demographic factors, comorbidities, dialysis vintage, body...