A5103162697- Ovarian cancer diagnosis and treatment
- Endometrial and Cervical Cancer Treatments
- Crystallization and Solubility Studies
- X-ray Diffraction in Crystallography
- Lymphatic System and Diseases
- Cervical Cancer and HPV Research
- Cancer Cells and Metastasis
- Marine and coastal ecosystems
- Marine Biology and Ecology Research
- Endometriosis Research and Treatment
- Prostate Cancer Treatment and Research
- Radiation Therapy and Dosimetry
- DNA Repair Mechanisms
- Marine and coastal plant biology
- Systemic Sclerosis and Related Diseases
- Effects of Radiation Exposure
- Cancer, Lipids, and Metabolism
- Urinary and Genital Oncology Studies
- Urbanization and City Planning
- Intraperitoneal and Appendiceal Malignancies
- Metastasis and carcinoma case studies
- Cancer-related Molecular Pathways
- Cancer-related molecular mechanisms research
- Atmospheric chemistry and aerosols
- Agricultural Economics and Policy
Fukuoka Tokushukai Hospital
2017-2024
Kyoto University Hospital
2006-2022
Osaka Medical and Pharmaceutical University
2012-2020
Jikei University School of Medicine
1999-2020
Jikei University Kashiwa hospital
2007-2017
University of Tsukuba
1976-2007
National Hospital Organization Kyushu Cancer Center
2007
Kurume University
2007
Shinshu University
2007
Kyushu University
1966-2007
To assess the efficacy of fertility-sparing treatment using medroxyprogesterone acetate (MPA) for endometrial carcinoma (EC) and atypical hyperplasia (AH) in young women.This multicenter prospective study was carried out at 16 institutions Japan. Twenty-eight patients having EC presumed stage IA 17 with AH younger than 40 years age were enrolled. All given a daily oral dose 600 mg MPA low-dose aspirin. This continued 26 weeks, as long responded. Histologic change tissue assessed 8 weeks...
Abstract One hundred and one cases of clinical prostatic carcinoma (PCa), primary site, were analysed to define the inter‐relationship between tumour angiogenesis, histological grade, bone marrow metastasis. Tumour angiogenesis was determined by blood capillary density ratio (BCDR; a / b ), defined as area capillaries ( ) ). The BCDR evaluated colour image analysis system employing computerized morphometrical method. A total 43 PCa with metastasis (stage D2) 58 without B, C) utilized....
The epithelial-mesenchymal-transition (EMT) is an important step in the invasion and metastasis of cancer. A critical molecular feature this process downregulation E-cadherin expression, which primarily controlled by Snail-related zinc-finger transcription factors. aim study was to evaluate prognostic impact expression EMT-related proteins (E-cadherin Snail) patients with ovarian An immunohistochemical analysis conducted using tissue microarray samples 174 primary tumors 34 metastases...
The degree of peritoneal dissemination and chemotherapy-resistant tumors is related to the prognosis in patients with advanced-stage ovarian cancer. epithelial-mesenchymal-transition (EMT) a multifaceted pathological program that endows cancer cells ability invade disseminate. CD24 frequently overexpressed various human cancers correlated poor prognosis. We herein examined functions cell lines evaluated how it contributes molecular mechanism underlying regeneration stem-like (CSCs) through...
Lymph node dissection has proven prognostic benefits for patients with ovarian or uterine carcinoma; however, one of the complications associated this procedure is lymphedema. We aimed to identify factors that are occurrence lymphedema after lymph treatment carcinoma.A total 694 histologically confirmed (135 patients) cancer (258 cervical cancer, 301 endometrial cancer) who underwent were studied retrospectively. Logistic regression analyses used risk lymphedema.Among and pelvic dissection,...
Human epididymis protein 4 (HE4) levels and the Risk of Ovarian Malignancy Algorithm (ROMA) have recently been shown to improve sensitivity specificity epithelial ovarian cancer (EOC) diagnosis. We evaluated HE4 ROMA as diagnostic tools type I II EOC in Japanese women. Women who had a pelvic mass on imaging were scheduled undergo surgery enrolled patients. Serum carbohydrate antigen 125 (CA125) tested 319 women (131 benign, 19 borderline, 75 malignant, 94 healthy controls). CA125, HE4, for...
To examine the effectiveness of systemic chemotherapy following radical hysterectomy for women with intermediate-risk stage IB cervical cancer.This is a retrospective analysis previously organized nation-wide cohort study examining 6,003 IB-IIB cancer who underwent between 2004 and 2008 in Japan. Survival 555 group (deep stromal invasion > 50%, large tumor size 4 cm, lympho-vascular space [LVSI]) were examined based on adjuvant therapy patterns: alone (n = 223, 40.2%), concurrent...
We previously reported that cyclin E (CCNE1) amplification is strongly associated with resistance to treatment in serous ovarian cancer by high-resolution oligonucleotide copy number analysis. Dysregulation of cell cycle control has been implicated as the key event human oncogenesis, and aberrant expression G1-S phase-related genes particular epithelial (EOC). Nevertheless, there are conflicting results concerning prognostic values these abnormalities EOC. This study focused on advanced EOC...
Using patient questionnaires, we studied the long-term effect of leaving peritoneum open on incidence lymphedema legs in patients following pelvic lymphadenectomy for gynecological malignancies. The were retrospectively assigned to one two groups, depending whether retroperitoneum was closed or left at surgery. Three years after surgery, obtained valid questionnaire responses from 101 (43 cervical, 46 endometrial, and 12 ovarian cancers) closure group 83 (34 40 9 nonclosure group. In...
This is the first report to determine feasibility and safety of total laparoscopic modified radical hysterectomy (TLMRH) in treatment presumed stage I endometrial cancer.This was a retrospective study 132 consecutive patients who underwent surgery for early cancer. Thirty-nine TLMRH bilateral salpingo-oophorectomy (BSO), 93 had abdominal extrafascial BSO. Lymphadenectomy performed 87 patients. The groups were compared epidemiological clinical characteristics, surgical outcomes, hospital...
CD24, a small heavily glycosylated mucin-like glycosyl-phosphatidylinositol-anchored cell surface protein, plays an important role in the carcinogenesis of various human malignancies. However, its function cervical cancer remains unclear. The aim present study was to evaluate expression CD24 clinicopathologically and analyze functional behavior biologically cancer. A total 117 uterine tumors were immunohistochemically analyzed using monoclonal antibody on paraffin blocks. We also examined...
A moored system was designed for monitoring both long-and short-term temporal variations in phytoplankton communities.It consisted of a chlorophyll buoy, current meter and sequential, multiple-sampling sedment trap, set at depths 52.57 120 m. respectively.The deployed 7Oo11.54'S, 24"18.68'E Breid Bay, Antarctica, from 28 December 1985 to 13 February 1986.A total 1127 hourly data sets 12 trap samples were obtained.Equivalent concentration fluctuated mainly the range 0.69 5.60 yg 1-l; values...
Liquid-based cytology (LBC) and conventional (CS) are routine diagnostic techniques in cervical cytology, but few studies have compared their performances with each other histologic diagnosis. This study aimed to compare the of these subjects abnormal atypical cells undetermined significance (ASC-US) or worse.A total 312 patients diagnosed ASC-US worse were enrolled this prospective Japan from 2013 2014. LBC CS samples prepared by a split-sampling technique evaluated blindly. The results...
It is well known that ovarian mature cystic teratomas (MCTs) occasionally go through malignant transformations. Among these, approximately 75% of histological types are squamous cell carcinoma, with the other being exceptionally rare. We report an extremely rare case clear carcinoma arising from teratoma. The was a 71-year-old woman abdominal distention. Ultrasonography and magnetic resonance imaging showed huge mass in her cavity. Fluorodeoxyglucose-positron emission tomography (FDG-PET)...
Lymphedema of lower extremities occurs following surgical resection malignant tumors and intrapelvic lymph node dissection is a long-term problem for patients. We performed primary lymphaticovenular anastomosis to prevent postoperative leg lymphedema. The procedures were conducted in 7 patients (aged 35-61 years) with cancer the uterine body. After completion hystero-oophorectomy dissection, afferent lymphatics entering internal external iliac nodes end-to-end anastomosed branches deep...
// Tomohito Tanaka 1, 4 , Yoshito Terai Satoe Fujiwara 1 Yoshimichi Hiroshi Sasaki Satoshi Tsunetoh Kazuhiro Yamamoto 2, 5 Takashi Yamada 3 Yoshifumi Narumi 2 and Masahide Ohmichi Department of Obstetrics Gynecology, Osaka Medical College, Takatsuki, Japan Radiology, Pathology, First Towakai Hospital, Correspondence to: Tanaka, email: gyn123@osaka-med.ac.jp Keywords: endometrial cancer; diffusion weighted image; apparent coefficient; frozen section; grade Received: February 28, 2018...
The kinetics of binucleate cell formation and their relationship to the recovery primary damage were investigated using mouse mammary carcinoma cells (FM3A) grown in suspension. following results obtained: (i) percentage increased with dose a maximum on second or third day postirradiation when rate proliferation was at minimum; (ii) smaller two split doses (2 × 500 rad, 4-hr interval) than single (1000-rad) dose; (iii) decreased treatment Hanks' balanced salt solution (HBSS) immediately...