A5054646745- Renal Diseases and Glomerulopathies
- Genetic and Kidney Cyst Diseases
- Chronic Kidney Disease and Diabetes
- Vasculitis and related conditions
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Dialysis and Renal Disease Management
- Renal and Vascular Pathologies
- Parathyroid Disorders and Treatments
- Renal and related cancers
- Pediatric Urology and Nephrology Studies
- Systemic Lupus Erythematosus Research
- Eosinophilic Disorders and Syndromes
- IgG4-Related and Inflammatory Diseases
- Genetic Syndromes and Imprinting
- Diabetes Treatment and Management
- Renal cell carcinoma treatment
- Complement system in diseases
- Sarcoidosis and Beryllium Toxicity Research
- Bone health and treatments
- Biomedical Research and Pathophysiology
- Rheumatoid Arthritis Research and Therapies
- Medical Imaging and Pathology Studies
- Viral-associated cancers and disorders
- Systemic Sclerosis and Related Diseases
- Liver Disease Diagnosis and Treatment
Toranomon Hospital
2016-2025
Kanazawa University
2018-2023
Kanazawa Medical University
2023
Joslin Diabetes Center
2015-2018
Harvard University
2015-2018
Hospital Clínic de Barcelona
2017
Ospedale Annunziata di Cosenza
2017
Kyorin University
2014
Okinaka Memorial Institute for Medical Research
2013
In recent years, a concept of renal rehabilitation has become widely known among nephrology specialists, dialysis kidney transplantation nutrition guideline nurses, physiotherapists, and representatives patients. Therefore, in order to make it clear the definition, methods, effectiveness Japan, we launched Renal Rehabilitation Guideline Preparation Committee 2016 as part works Japanese Society Rehabilitation, created accordance "Minds Handbook for Clinical Practice Development 2014". Here,...
Some biomarkers of renal tubular injury are reported to be useful for predicting prognosis in the early stage diabetic nephropathy (DN). Our study compared predictions by such and histologic tubulointerstitial damage.Among 210 patients with type 2 diabetes biopsy-proven DN managed from 1985 2011, 149 urinary N-acetyl-β-d-glucosaminidase (NAG) β2-microglobulin (β2-MG) data at time biopsy were enrolled. The primary outcome was a decline eGFR ≥50% baseline or commencement dialysis ESRD.The...
OBJECTIVE Clinicopathological characteristics, renal prognosis, and mortality in patients with type 2 diabetes reduced function without overt proteinuria are scarce. RESEARCH DESIGN AND METHODS We retrospectively assessed 526 (estimated glomerular filtration rate [eGFR] <60 mL/min/1.73 m2), who underwent clinical biopsy had follow-up data, from Japan’s nationwide multicenter registry. For comparative analyses, we derived one-to-two cohorts of those versus using propensity...
BackgroundA new classification of diabetic nephropathy was reported by Tervaert et al., but the association between pathological findings and clinical outcomes remains unclear.
The effect of clinical and pathological parameters on the estimated glomerular filtration rate (eGFR) decline has not been investigated in patients with type 2 diabetes overt proteinuric biopsy-proven diabetic nephropathy.Among 198 who underwent renal biopsy were confirmed to have pure nephropathy according recent classification, 128 proteinuria enrolled. Receiver operating characteristic, net reclassification improvement (NRI) integrated discrimination (IDI) analyses performed using models...
Abstract Evidence for the efficacy of denosumab in HD patients is limited. Accordingly, here we report a study on safety and these patients. We prospectively followed 324 (121 203 non-HD patients) receiving between June 2013 May 2018, assessing changes bone mineral density (BMD) metabolic markers, noting side-effects. Annual BMD at lumbar spine from baseline were, respectively, 6.7 ± 11.1% 7.5 10.2% ( p = 0.60), those femoral neck were 4.3 7.9% 3.1 9.5% 0.32), distal radius −0.5 6.4% 0.2...
The quality of life (QOL) patients with autosomal dominant polycystic kidney disease (ADPKD) has not been investigated well. This study was performed to clarify the QOL ADPKD and identify factors that affected their QOL. present cross-sectional is part a prospective observational on patients. Patients who were referred Toranomon Hospital between March 2010 November 2012 enrolled. short form-36 (SF-36) questionnaire our original 12-item used evaluate We analyzed results survey then...
<b><i>Background:</i></b> With the association between diabetic nephropathy (DN) and renal outcome being increasingly clear, we aimed at creating a new DN pathological scoring system that could predict outcome. <b><i>Methods:</i></b> We studied 205 patients with confirmed by biopsy, sometime March 1985 January 2010, who met inclusion criteria. Renal biopsy included clinical parameters Tervaert classifications. Hazard ratios (HRs) for...
Objective The predictive value of diabetic retinopathy on end-stage kidney disease (ESKD) has not been fully addressed in patients with type 2 diabetes and disease. Research design methods We studied 232 biopsy-proven who were screened for during the 1 month biopsy. examined association between progression renal lesions. used Cox regression analyses to explore risk ESKD adjusting known demographic clinical variables. assessed incremental prognostic by adding Results positively correlated all...
ABSTRACT Introduction The DAPA-CKD study showed a protective effect of dapagliflozin on kidney function in chronic disease (CKD) patients with and without diabetes mellitus. Although is expected to be effective also CKD autosomal dominant polycystic (ADPKD), its efficacy safety this population remain unknown because ADPKD was an exclusion criterion the study. Therefore, we evaluated effects ADPKD. Methods We performed retrospective observational seven treated at Toranomon Hospital, Tokyo,...
A 58-year-old Japanese woman on hemodialysis (HD) was admitted for intractable rheumatoid arthritis. Even after HD started due to end-stage renal failure in 2004, her arthropathy worsened. soluble tumor necrosis factor receptor inhibitor (etanercept at 25 mg twice weekly), tacrolimus (2 daily), and prednisolone (10 daily) had been administered since 2005, but high disease activity persisted. She our hospital July 2007. C-reactive protein (CRP) 6.8 mg/dL, the DAS-CRP score calculated be 8.3....
Introduction The speed of declining kidney function differs among patients with diabetic nephropathy. This study was undertaken to clarify clinical and pathological features that affect the in Research design methods as multicenter retrospective study. subjects (377 nephropathy diagnosed by biopsy at 13 centers Japan) were classified into three groups based on estimated glomerular filtration rate (eGFR) speed. eGFR increasing group, control group divided 0 5 mL/min/1.73 m 2 /year,...
Thrombocytopenia, anasarca, myelofibrosis, renal dysfunction, and organomegaly (TAFRO) syndrome is a severe subtype of idiopathic multicentric Castleman's disease, characterized by thrombocytopenia, fever, reticulin organomegaly. Renal complication this disease can be life-threatening sometimes requires hemodialysis, but it has not been elucidated in detail.Case-series was designed to evaluate the histology patients with TAFRO treated at our hospital.Seven were eligible criteria. All them...
Abstract Objectives To evaluate the efficacy and safety of first-line targeted synthetic disease-modifying anti-rheumatic drugs (tsDMARDs) in patients with rheumatoid arthritis (RA) chronic kidney disease (CKD). Methods This retrospective cohort study included 216 RA prescribed their first tsDMARDs at two hospitals between 2013 2022. Dose reduction contraindication guidelines for according to function were followed. The categorised by tsDMARD modality. primary outcome was 24-month drug...