A5050421436- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Prenatal Screening and Diagnostics
- Cardiac electrophysiology and arrhythmias
- Chromosomal and Genetic Variations
- Genomic variations and chromosomal abnormalities
- ECG Monitoring and Analysis
- Cardiovascular Function and Risk Factors
- Advanced MRI Techniques and Applications
- Reproductive Biology and Fertility
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac Imaging and Diagnostics
- Venous Thromboembolism Diagnosis and Management
- Sarcoidosis and Beryllium Toxicity Research
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Neurological disorders and treatments
- Advanced Sensor and Energy Harvesting Materials
- Telemedicine and Telehealth Implementation
- Parvovirus B19 Infection Studies
- Public Administration and Political Analysis
- Single-cell and spatial transcriptomics
- Cleft Lip and Palate Research
- IL-33, ST2, and ILC Pathways
- EEG and Brain-Computer Interfaces
Kobe University
2019-2025
Kobe University Hospital
2020
Kobe Rosai Hospital
2019
Hiroshima University
1970-1978
Abstract The areas with electrically fractionated potentials (AEFP) during sinus rhythm are related to non-pulmonary vein triggers and may serve as substrates of atrial fibrillation (AF) maintenance. However, the histological properties these compounds remain unclear. Therefore, we aimed evaluate late gadolinium enhancement (LGE) AEFP in patients AF. We enrolled 15 AF who had undergone LGE magnetic resonance imaging before catheter ablation. left atrium was detected using HD-Grid NavX...
Abstract Background Cryoballoon ablation (CBA) is useful for pulmonary vein (PV) isolation. However, some cases are challenging, requiring multiple applications and/or touch‐up ablations. Although several predictors of CBA difficulty have been reported, none assessed the spatial location and morphology left atrium PVs. This study aimed to develop a three‐dimensional (3D) deep learning (DL) model predict compare its accuracy with conventional manual measurement. Methods A 28‐mm cryoballoon...
Atrial fibrillation (AF) is strongly associated with strokes, heart failure, and increased mortality. This study aims to identify the monocyte–macrophage heterogeneity interactions of these cells non-immune cells, functional biomarkers in patients AF. Therefore, we assess single cell landscape left atria (LA), using a combination nucleus RNA-seq. Myeloid LA tissue are categorized into five macrophage clusters, three monocyte others. Cell-Chat analysis revealed that monocytes IL1B+...
Abstract Background A computational model demonstrated that atrial fibrillation (AF) rotors could be distributed in patchy late‐gadolinium enhancement (LGE) areas and play an important role AF drivers. However, this was not validated humans. Objective The purpose of study to evaluate the LGE properties patients with persistent AF. Methods total 287 segments 15 (long‐standing 9 patients) underwent ablation were assessed. Non‐passively activated (NPAs), where rotational activation (AF rotor)...
Several algorithms have been proposed for differentiating the right and left outflow tracts (RVOT/LVOT) arrhythmia origins from 12-lead electrocardiograms (ECGs); however, procedure is complicated. A deep learning (DL) model, a form of artificial intelligence, can directly use ECGs depict importance leads waveforms. This study aimed to create visualized DL model that could classify more accurately.
A computer simulation model has demonstrated that atrial fibrillation (AF) driver can be attached to heterogeneous fibrosis assessed by late gadolinium enhancement magnetic resonance imaging (LGE-MRI). However, it not been well elucidated in patients with persistent AF. The aim of this study was investigate whether radiofrequency (RF) applications the fragmented LGE area (FLA) could terminate AF or convert tachycardia (AT) and improve rhythm outcome.A total 31 consecutive FLAs were enrolled...
Background Medium-dose (25 gray) x-ray radiation therapy has recently been performed on patients with refractory ventricular tachyarrhythmias. Unlike x-ray, carbon ion and proton beam can deliver most of their energy to the target tissues. This study investigated electrophysiological pathological changes caused by medium-dose in left ventricle (LV). Methods Results External whole LV was 32 rabbits. A total 9 rabbits were not irradiated (control). At 3-month or 6-month follow-up, animals...
Some of atrial fibrillation (AF) drivers are found in normal/mild late-gadolinium enhancement (LGE) areas, as well moderate ones. The wall thickness (AWT) has been reported to be important a possible AF substrate. However, the AWT and degree LGEs an substrate not fully validated humans.
The skin overlying cardiovascular implantable electronic devices (CIEDs) sometimes becomes very thin after implantations, which could cause a device erosion. factors related to the thickness of pockets have not been elucidated. This study aimed evaluate CIED and search for associated with thickness.Seventeen points around pocket were measured through ultrasonography in each patient.A total 101 patients (76 ± 11 years, 26 female) enrolled. median duration from implantation examination was 95...
Abstract A 41‐year‐old man with persistent atrial fibrillation (AF) underwent radiofrequency (RF) catheter ablation using an online real‐time phase mapping system: ExTRa Mapping. Box isolation could not terminate AF. Subsequently, RF applications on nonpassively activated areas (NPAs), where rotational activations were frequently observed, at the posterior bottom of left atrium outside box lesion convert AF to common flutter. Of interest, NPA near located patchy fibrotic tissue area assessed...
An attempt was made to assess fetal sex by means of chromosome analysis following the procedure Walkonowska, Conte, and Grumbach (1969). Peripheral venous blood obtained from 23 pregnant women between 11 38 weeks gestation. Leucocyte cultures were prepared more than 50 well-defined metaphase plates for each sample examined. Karotype carried out on with small acrocentrics G groups. 4 showed 1 or 2 figures 46 47 chromosomes including 5 acrocentrics. thought be Y chromosome. 3 containing...
Abstract Background Inflammation, such as that associated with intermediate CD14 ++ CD16 + monocytes and atrial structural remodeling (SRM), may be important in the recurrence of fibrillation (AF) after catheter ablation. However, relationship between monocytes, SRM, AF is unclear. Methods Twenty‐four patients were enrolled. The proportion (PIM) was assessed before ablation by flow cytometry. As a surrogate marker volume ratio (VR) signal intensity greater than 1 standard deviation on...
Cytogenetic and clinical features are presented in a 8-month-old female infant with many symptoms compatible Down's syndrome. Leucocyte samples from this patient show 46 chromosomes. Karyotype analysis has revealed that one of the G chromosomes is missing, occurrence an extra chromosome which apparently corresponds size to D carries satellite. A tandem G/G translocation most plausible interpret abnormality patient. The parents normal.
Background:Demand is growing for remote electrocardiogram (ECG) monitoring systems in the COVID-19 era Japan. This study describes initial experiences with a small wireless ECG device and utility of delivery via postal service outpatient care
The mechanism underlying the sex differences in atrial fibrillation (AF) recurrence following pulmonary vein (PV) isolation is not fully understood. We hypothesized that non-PV foci and epicardial adipose tissue (EAT) play a key role.