A5038111929- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- High Altitude and Hypoxia
- Adipose Tissue and Metabolism
- Nutrition and Health in Aging
- Asthma and respiratory diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pulmonary Hypertension Research and Treatments
- Occupational exposure and asthma
- Body Composition Measurement Techniques
- Air Quality and Health Impacts
- Phytoestrogen effects and research
- Regulation of Appetite and Obesity
- Pediatric health and respiratory diseases
- Heme Oxygenase-1 and Carbon Monoxide
- Muscle Physiology and Disorders
Osaka City University
2016-2019
National Cerebral and Cardiovascular Center
2017
Oxidative stress plays an important role in the pathogenesis of chronic obstructive pulmonary disease (COPD). The activation nuclear factor erythroid 2-related 2 (Nrf2) is a key cellular defense mechanism against oxidative stress. Recent studies have shown that astaxanthin protects via Nrf2. In this study, we investigated emphysema suppression effect Nrf2 mice. Mice were divided into four groups: control, smoking, astaxanthin, and + smoking. mice smoking groups exposed to cigarette smoke for...
Pulmonary fibrosis is a life-threatening disease characterized by progressive dyspnea and worsening pulmonary function. Atrial natriuretic peptide (ANP), heart-derived secretory used clinically in Japan for the treatment of acute heart failure, exerts wide range protective effects on various organs, including heart, blood vessels, kidneys, lungs. Its therapeutic properties are anti-inflammatory anti-fibrotic activities mediated guanylyl cyclase-A (GC-A) receptor. We hypothesized that ANP...
Background: Oxidative stress is one of the important mechanisms underlying pathogenesis chronic obstructive pulmonary disease (COPD). Irisin a type myokine secreted from muscle during exercise and acts against oxidative via nuclear factor erythroid 2-related 2 (Nrf2), transcription with antioxidant properties. Here, we examined emphysema suppressive effects exercise-irisin-Nrf2 axis in mice. Methods: Mice were divided into three groups, namely, control, smoking, + smoking groups. All mice...
Chronic obstructive pulmonary disease (COPD), a lung caused by chronic exposure to cigarette smoke, increases the number of inflammatory cells such as macrophages and neutrophils emphysema. Isoflavone is polyphenolic compound that exists in soybeans. Daidzein genistein, two types isoflavones, have been reported anti-inflammatory effects various organs. We hypothesized daidzein-rich soy isoflavone aglycones (DRIAs) attenuate smoke-induced emphysema mice. Mice were divided into four groups:...
<b>Background</b> Sarcopenia is defined as the loss of limb skeletal muscle mass and weakness. Aging some other factors are known to contribute its development. Although sarcopenia appeared in patients with COPD, relationships pulmonary function, exercise capacity, prognosis has not been well understood. <b>Objectives</b> To determine between COPD. <b>Methods</b> Thirty-six stable male COPD (69.8 years old, % FEV1;52.7%) were recruited 2003 2005. Body composition was evaluated by...
<b>Background:</b> Pulmonary fibrosis is a life-threatening disease characterized by progressive dyspnea and worsening of pulmonary function. Ghrelin growth hormone-releasing peptide originally isolated from the rat stomach in 1999. The actions ghrelin include appetite stimulation, carbohydrate utilization, hormone release. Recent studies have shown that has various anti-inflammatory effects experimental models. <b>Aims objective:</b> We hypothesized had anti-fibrotic on bleomycin...
<b>Background:</b> Chronic Obstructive Pulmonary Disease (COPD) is a pulmonary disease caused by long-term inhalation exposure of harmful substances, mainly cigarette smoke. Oxidative stress considered as one the important mechanisms COPD. Irisin kind myokine secreted from muscle exercise. Recent studies have shown that irisin acts defensively against oxidative via Nrf2, transcription factor responsible for antioxidant capacity. In this study, we examined emphysema suppression effect...