A5014096310- Transplantation: Methods and Outcomes
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Organ Transplantation Techniques and Outcomes
- Medical Imaging and Pathology Studies
- Sarcoidosis and Beryllium Toxicity Research
- Inhalation and Respiratory Drug Delivery
- Renal Transplantation Outcomes and Treatments
- Cystic Fibrosis Research Advances
- Mechanical Circulatory Support Devices
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pulmonary Hypertension Research and Treatments
- Neonatal Respiratory Health Research
- Tracheal and airway disorders
- Organ and Tissue Transplantation Research
- Respiratory viral infections research
- Systemic Sclerosis and Related Diseases
- Pediatric health and respiratory diseases
- Asthma and respiratory diseases
- Respiratory and Cough-Related Research
- Respiratory Support and Mechanisms
- Pneumocystis jirovecii pneumonia detection and treatment
- Polyomavirus and related diseases
- Eosinophilic Disorders and Syndromes
- Viral Infections and Immunology Research
- Pleural and Pulmonary Diseases
University of Wisconsin–Madison
2014-2024
University of Alabama at Birmingham
2018
Medical University of South Carolina
2017
Johnson & Johnson (Brazil)
2016
Pfizer (United States)
2016
GlaxoSmithKline (United Kingdom)
2016
Bayer (United States)
2016
Boehringer Ingelheim (France)
2016
Landscape Research Group
2016
Canadian Respiratory Research Network
2016
Current theories of CF pathogenesis predict different predisposing “local environmental” conditions and sites bacterial infection within airways. Here we show that, in patients with established lung disease, Psuedomonas aeruginosa was located hypoxic mucopurulent masses airway lumens. In vitro studies revealed that CF-specific increases epithelial O2 consumption, linked to increased surface liquid (ASL) volume absorption mucus stasis, generated steep gradients thickened on surfaces prior...
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Current theories of CF pathogenesis predict different predisposing “local environmental” conditions and sites bacterial infection within airways. Here we show that, in patients with established lung disease, Psuedomonas aeruginosa was located hypoxic mucopurulent masses airway lumens. In vitro studies revealed that CF-specific increases epithelial O2 consumption, linked to increased surface liquid (ASL) volume absorption mucus stasis, generated steep gradients thickened on surfaces prior...
Bronchiolitis obliterans syndrome (BOS) is a major complication of lung transplantation that associated with poor survival. The International Society for Heart and Lung Transplantation, American Thoracic Society, European Respiratory convened committee international experts to describe and/or provide recommendations 1) the definition BOS, 2) risk factors developing 3) diagnosis 4) management prevention BOS. A pragmatic evidence synthesis was performed identify all unique citations related...
Bronchiolitis obliterans syndrome (BOS), a process of fibro-obliterative occlusion the small airways in transplanted lung, is most common cause lung transplant failure. We tested role cell-mediated immunity to collagen type V [col(V)] this process. PBMC responses col(II) and col(V) were monitored prospectively over 7-year period. PBMCs from recipients, but not healthy controls or col(IV)-reactive Goodpasture's patients after renal transplant, frequently reactive. Col(V)-specific dependent on...
Heterozygous mutations in four telomere-related genes have been linked to pulmonary fibrosis, but little is known about similarities or differences of affected individuals. 115 patients with telomerase reverse transcriptase ( TERT ) (n=75), RNA component TERC (n=7), regulator telomere elongation helicase 1 RTEL1 (n=14) and poly(A)-specific ribonuclease PARN (n=19) were identified clinical data analysed. Approximately one-half (46%) had a multidisciplinary diagnosis idiopathic fibrosis (IPF);...
Idiopathic pulmonary fibrosis is a progressive, fatal disease. This prospective, randomised, double-blind, multicentre, parallel-group, placebo-controlled phase II trial (NCT00903331) investigated the efficacy and safety of endothelin receptor antagonist macitentan in idiopathic fibrosis. Eligible subjects were adults with <3 years duration histological pattern usual interstitial pneumonia on surgical lung biopsy. The primary objective was to demonstrate that (10 mg once daily) positively...
Rationale: Current diagnosis of chronic hypersensitivity pneumonitis (cHP) involves considering a combination clinical, radiological, and pathological information in multidisciplinary team discussions. However, this approach is highly variable with poor agreement between centers.Objectives: We aimed to identify diagnostic criteria for cHP that reach consensus among international experts.Methods: A three-round modified Delphi survey was conducted April August 2017. total 45 experts...
Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease with poor prognosis. Approved therapies do not halt progression.To determine the effect of recombinant human pentraxin 2 vs placebo on change from baseline to week 28 in mean forced vital capacity (FVC) percentage predicted value.Phase 2, randomized, double-blind, placebo-controlled trial conducted at 18 sites 7 countries eligible patients IPF (N = 117; aged 40-80 years; FVC ≥50% and ≤90% predicted; ratio expiratory...
We conducted a placebo-controlled, double-blind, randomized study to evaluate the microbiological efficacy and safety of inhaled tobramycin for treatment patients with bronchiectasis Pseudomonas aeruginosa. Patients were randomly assigned receive either solution inhalation (TSI) (n = 37) or placebo 37), which was self-administered twice daily 4 wk followed by 2-wk off-drug. At Week 4, TSI group had mean decrease in P. aeruginosa density 4.54 log10 colony-forming units (cfu)/g sputum compared...
Although rhinovirus (RV) infections can cause asthma exacerbations and alter lower airway inflammation physiology, it is unclear how important bronchial infection to these processes. To study the kinetics, location, frequency of RV appearance in tissues during an acute infection, immunohistochemistry quantitative polymerase chain reaction analysis were used analyze presence virus cells from nasal lavage, sputum, bronchoalveolar brushings, biopsy specimens 19 subjects with experimental...
Primary graft dysfunction (PGD) is a principal cause of early morbidity and mortality after lung transplantation, but its pathogenic mechanisms are not fully clarified. To date, studies using standard clinical assays have linked microbial factors to PGD. We previously used comprehensive metagenomic methods characterize viruses in allografts >1 mo transplant found that levels Anellovirus, mainly torque teno (TTVs), were significantly higher than nontransplanted healthy controls. quantitative...
Aging has been associated with diminished lung function and increased susceptibility to infection. To determine whether changes suggestive of immune dysregulation inflammation appear in the lungs clinically normal individuals as a advancing age, we performed bronchoalveolar lavage (BAL) on discontinuous age groups (20-36, 45-55, 65-78 yr old) volunteer subjects. We measured immunoglobulin (IgG, IgA, IgM), albumin, interleukin-6 (IL-6), interleukin-10 concentrations BAL fluid. Bronchoalveolar...
Current theories of CF pathogenesis predict different predisposing “local environmental” conditions and sites bacterial infection within airways. Here we show that, in patients with established lung disease, Psuedomonas aeruginosa was located hypoxic mucopurulent masses airway lumens. In vitro studies revealed that CF-specific increases epithelial O2 consumption, linked to increased surface liquid (ASL) volume absorption mucus stasis, generated steep gradients thickened on surfaces prior...