A5011241755- Neurobiology and Insect Physiology Research
- Developmental Biology and Gene Regulation
- Circadian rhythm and melatonin
- Congenital heart defects research
- Genomics and Chromatin Dynamics
- Plant Molecular Biology Research
- Photoreceptor and optogenetics research
- Retinal Development and Disorders
- Animal Behavior and Reproduction
- Olfactory and Sensory Function Studies
- Axon Guidance and Neuronal Signaling
- Studies on Chitinases and Chitosanases
- Hedgehog Signaling Pathway Studies
- Genetics, Aging, and Longevity in Model Organisms
- Diet and metabolism studies
- Microbial Metabolites in Food Biotechnology
- Chromosomal and Genetic Variations
- Diet, Metabolism, and Disease
- Photochromic and Fluorescence Chemistry
- dental development and anomalies
- Biochemical and Structural Characterization
- Pluripotent Stem Cells Research
- RNA Research and Splicing
- CRISPR and Genetic Engineering
Institut des Neurosciences Paris-Saclay
2017-2019
Université Paris-Sud
2017-2019
Université Paris-Saclay
2017-2019
Centre National pour la Recherche Scientifique et Technique (CNRST)
2019
Centre National de la Recherche Scientifique
2019
Université Paris Cité
2017
Institut Jacques Monod
2017
New York University
2008-2013
Columbia University
1998-2003
University of Toronto
2001
The Drosophila eye is a mosaic that results from the stochastic distribution of two ommatidial subtypes. Pale and yellow ommatidia can be distinguished by expression distinct rhodopsins other pigments in their inner photoreceptors (R7 R8), which are implicated color vision. pale subtype contains ultraviolet (UV)-absorbing Rh3 R7 blue-absorbing Rh5 R8. UV-absorbing Rh4 green-absorbing Rh6 exclusive one rhodopsin per photoreceptor widespread phenomenon, although exceptions exist. mechanisms...
Current fructose consumption levels often overwhelm the intestinal capacity to absorb fructose. We investigated impact of malabsorption on endocrine function and addressed role microbiota in this process. To answer question, a mouse model moderate [ketohexokinase mutant (KHK)−/−] wild-type (WT) littermate mice were used received 20%-fructose (KHK-F WT-F) or 20%-glucose diet. Cholecystokinin (Cck) mRNA protein expression ileum cecum, as well preproglucagon (Gcg) neurotensin (Nts) increased...
The compound eye of Drosophila melanogaster consists about 750 ommatidia (unit eyes). Each ommatidium is composed 20 cells, including lens-secreting cone pigment a bristle cell and eight photoreceptors (PRs) R1-R8 2. PRs have specialized microvillar structures, the rhabdomeres, which contain light-sensitive pigments, Rhodopsins (Rhs). rhabdomeres six (R1-R6) form trapezoid Rh1 3 4. R7 R8 are positioned in tandem center share same path light. stochastically express different combinations Rhs...
Each individual perceives the world in a unique way, but little is known about genetic basis of variation sensory perception. In fly eye, random mosaic color-detecting R7 photoreceptor subtypes determined by stochastic on/off expression transcription factor Spineless (Ss). genome-wide association study, we identified naturally occurring insertion regulatory DNA element ss that lowers ratio SsON to SsOFF cells. This change fates shifts innate color preference flies from green blue. The...
In Drosophila, the clock that controls rest-activity rhythms synchronizes with light-dark cycles through either blue-light sensitive cryptochrome (Cry) located in most neurons, or rhodopsin-expressing histaminergic photoreceptors. Here we show that, absence of Cry, each two histamine receptors Ort and HisCl1 contribute to entrain whereas no entrainment occurs receptors. contrast Ort, does not restore when expressed optic lobe interneurons. Indeed, is wild-type photoreceptors strongly...
We describe a novel chick WD-protein, cSWiP-1, expressed in somitic mesoderm and developing limb buds as well other embryonic structures where Hedgehog signalling has been shown to play role. Using manipulations we show that somites cSWiP-1 expression integrates two signals originating from adjacent the segmental mesoderm: positive signal notochord negative intermediate and/or lateral mesoderm. In explant cultures of mesoderm, Shh protein induces while blocking antibody inhibits induction by...
Abstract Each individual perceives the world in a unique way, but little is known about genetic basis of variation sensory perception. Here we investigated natural development and function color vision system Drosophila . In fly eye, random mosaic color-detecting R7 photoreceptor subtypes determined by stochastic expression transcription factor Spineless (Ss). Individual R7s randomly choose between Ss ON or OFF fates at ratio 65:35, resulting patterns consistent proportions cell types across...
A recent paper(1) describes a striking expression pattern during somite formation for chick ortholog of the fly hairy gene. Before segmentation, c-hairy1 mRNA oscillates in presomitic mesoderm such that three distinct spatial patterns are seen. The authors use series ingenious manipulations to show these phases follow each other time, adding up 90-minute periodicity expression. discovery this clock gene emphasizes importance temporally regulated events establishment patterns. BioEssays...