A5008734382- Neurogenesis and neuroplasticity mechanisms
- Zebrafish Biomedical Research Applications
- Congenital heart defects research
- Developmental Biology and Gene Regulation
- Neuroscience and Neuropharmacology Research
- Axon Guidance and Neuronal Signaling
- Receptor Mechanisms and Signaling
- Cardiovascular Disease and Adiposity
- Cellular transport and secretion
- MicroRNA in disease regulation
- Neuropeptides and Animal Physiology
- Phagocytosis and Immune Regulation
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Pain Mechanisms and Treatments
- Nitric Oxide and Endothelin Effects
- Circadian rhythm and melatonin
- Apelin-related biomedical research
- Neurobiology and Insect Physiology Research
- Glycosylation and Glycoproteins Research
- Photoreceptor and optogenetics research
- Neurotransmitter Receptor Influence on Behavior
- Fish biology, ecology, and behavior
Centre National de la Recherche Scientifique
2013-2025
Inserm
2024-2025
Université de Montpellier
2024-2025
Institut de Génomique Fonctionnelle
2023-2025
Université Paris-Sud
2016-2019
Institut des Neurosciences Paris-Saclay
2016-2019
Université Paris-Saclay
2018
Laboratoire de Neurobiologie Cellulaire et Moléculaire
2013-2015
Maintaining the homeostasis of germinal zones in adult organs is a fundamental but mechanistically poorly understood process. In particular, what controls stem cell activation remains unclear. We have previously shown that Notch signaling limits neural (NSC) proliferation zebrafish pallium. Combining pharmacological and genetic manipulations, we demonstrate here long-term invalidation primarily induces NSC amplification through their from quiescence increased occurrence symmetric divisions....
Urotensin II (UII) is an evolutionarily conserved neuropeptide initially isolated from teleost fish on the basis of its smooth muscle-contracting activity. Subsequent studies have demonstrated occurrence several UII-related peptides (URPs), such that UII family now known to include four paralogue genes called UII, URP, URP1 and URP2. These probably arose through two rounds whole genome duplication occurred during early vertebrate evolution. URP has been identified both in tetrapods teleosts....
Neurogenesis in the post-embryonic vertebrate brain varies extent and efficiency between species territories. Distinct neurogenesis modes may account for this diversity, several neural progenitor subtypes, radial glial cells (RG) neuroepithelial progenitors (NE), have been identified adult zebrafish brain. The neurogenic sequences issued from these progenitors, their contribution to construction, remain incompletely understood. Here we use genetic tracing techniques based on conditional Cre...
In Drosophila, the clock that controls rest-activity rhythms synchronizes with light-dark cycles through either blue-light sensitive cryptochrome (Cry) located in most neurons, or rhodopsin-expressing histaminergic photoreceptors. Here we show that, absence of Cry, each two histamine receptors Ort and HisCl1 contribute to entrain whereas no entrainment occurs receptors. contrast Ort, does not restore when expressed optic lobe interneurons. Indeed, is wild-type photoreceptors strongly...
Although the overall brain organization is shared in vertebrates, there are significant differences within subregions among different groups, notably between Sarcopterygii (lobe-finned fish) and Actinopterygii (ray-finned fish). Recent comparative studies focusing on ventricular morphology have revealed a large diversity of hypothalamus. Here, we study development inferior lobe (IL), prominent structure forming bump ventral surface teleost brain. Based its position, IL has been thought to be...
Metabotropic glutamate receptor 2 (mGlu ) attracts particular attention as a possible target for new class of antipsychotics. However, the signaling pathways transducing effects mGlu in brain remain poorly characterized. Here, we addressed this issue by identifying native interactome mouse prefrontal cortex. Nanobody-based affinity purification and mass spectrometry identified 149 candidate partners, including neurotrophin TrkB. The later interaction was confirmed both cultured cells...
Abstract Chemokine receptor 4 (CXCR4) is a member of the chemokine exclusively activated by CXCL12. While CXCR4 regulates numerous physiological processes associated with cell migration and embryogenesis, its overexpression has been involved in various cancer types. Studies suggest that intracellular expression rather than CXCR4-operated signaling underlies pro-tumorigenic functions. Given role GPCR interacting proteins their trafficking subcellular localization, we characterized interactome...