A5093793990- Neuroscience and Neuropharmacology Research
- Receptor Mechanisms and Signaling
- Neuropeptides and Animal Physiology
Institut de Génomique Fonctionnelle
2024
Inserm
2024
Université de Montpellier
2024
Centre National de la Recherche Scientifique
2024
Metabotropic glutamate receptor 2 (mGlu ) attracts particular attention as a possible target for new class of antipsychotics. However, the signaling pathways transducing effects mGlu in brain remain poorly characterized. Here, we addressed this issue by identifying native interactome mouse prefrontal cortex. Nanobody-based affinity purification and mass spectrometry identified 149 candidate partners, including neurotrophin TrkB. The later interaction was confirmed both cultured cells...