A5054019195- Genetic Associations and Epidemiology
- Cholesterol and Lipid Metabolism
- Peroxisome Proliferator-Activated Receptors
- Genetic Neurodegenerative Diseases
- Cancer, Lipids, and Metabolism
- Drug Transport and Resistance Mechanisms
- Cardiomyopathy and Myosin Studies
- Liver Disease Diagnosis and Treatment
- Diet, Metabolism, and Disease
- Cannabis and Cannabinoid Research
- Alcohol Consumption and Health Effects
- Forensic and Genetic Research
- Mitochondrial Function and Pathology
- Systemic Lupus Erythematosus Research
- T-cell and B-cell Immunology
- Endoplasmic Reticulum Stress and Disease
- Nutrition, Genetics, and Disease
- Birth, Development, and Health
- Inflammasome and immune disorders
- Obesity, Physical Activity, Diet
- Adipose Tissue and Metabolism
- Pancreatic function and diabetes
- Genetic diversity and population structure
- Neurotransmitter Receptor Influence on Behavior
- Genetic Mapping and Diversity in Plants and Animals
National Institute of Genomic Medicine
2015-2025
National Legal Medicine Institute
2025
Universidad Católica de Santiago de Guayaquil
2025
Mexican Social Security Institute
2020
Instituto de Medicina Genómica
2013
Institute for Social Security and Services for State Workers
2008-2009
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2005
Universidad Nacional Autónoma de México
2005
Actua
2002
Mexico harbors great cultural and ethnic diversity, yet fine-scale patterns of human genome-wide variation from this region remain largely uncharacterized. We studied genomic within over 1000 individuals representing 20 indigenous 11 mestizo populations. found striking genetic stratification among populations at varying degrees geographic isolation. Some groups were as differentiated Europeans are East Asians. Pre-Columbian substructure is recapitulated in the ancestry admixed across...
Common polymorphisms in the fat mass and obesity‐associated gene ( FTO ) have shown strong association with obesity several populations. In present study, we explored of other biochemical parameters Mexican population. We also assessed expression levels adipose tissue obese nonobese individuals. The study comprised 788 unrelated Mexican‐Mestizo individuals 31 subcutaneous biopsies from lean women. single‐nucleotide (SNPs) rs9939609, rs1421085, rs17817449 were associated obesity, particularly...
It has been suggested that the higher susceptibility of Hispanics to metabolic disease is related their Native American heritage. A frequent cholesterol transporter ABCA1 (ATP-binding cassette A1) gene variant (R230C, rs9282541) apparently exclusive individuals was associated with low high-density lipoprotein (HDL-C) levels, obesity and type 2 diabetes in Mexican Mestizos. We performed a more extensive analysis this 4405 Americans 863 from other ethnic groups investigate genetic evidence...
Background Several studies have identified multiple obesity-associated loci mainly in European populations. However, their contribution to obesity other ethnicities such as Mexicans is largely unknown. The aim of this study was examine 26 single-nucleotide polymorphisms (SNP) a sample Mexican mestizos. Methods 9 SNPs biological candidate genes showing replications (PPARG, ADRB3, ADRB2, LEPR, GNB3, UCP3, ADIPOQ, UCP2, and NR3C1), 17 or near associated with first, second third wave GWAS...
Although ATP-binding cassette transporter A1 (ABCA1) is well known for its role in cholesterol efflux and HDL formation, it expressed various tissues, where may have different functions. Because hypoalphalipoproteinemia highly prevalent Mexico, we screened the ABCA1 coding sequence Mexican individuals with low high levels to seek functional variants. A frequent nonsynonymous variant (R230C) was identified low-HDL but not high-HDL (P = 0.00006). We thus assessed frequency Mexican-Mestizo...
The ATP-binding cassette transporter A1 (ABCA1) R230C variant is associated with low HDL cholesterol levels, obesity, and the metabolic syndrome in Mexican-Mestizos. Because a pivotal role for ABCA1 pancreatic beta-cell function was recently observed mouse model, we assessed association of this type 2 diabetes population.The initial group included 446 unrelated Mexican individuals: 244 aged 20-69 years (121 onset </=45 years), 202 nondiabetic control subjects >50 years. An independent study...
Objective Irisin is a novel myokine that seems to mediate the beneficial effects of exercise. Levels circulating irisin before and after an 8‐month physical activity program (PAP) in school‐age children were evaluated. Methods leptin measured at baseline follow‐up among 85 with different BMI. Results Of (mean age 8.9; 47% female), 25 had normal weight, 23 overweight, 37 obesity. We observed no significant difference serum levels between boys girls. was positively associated BMI PAP ( r =...
ABCA1 genetic variation is known to play a role in HDL-C levels and various studies have also implicated cardiovascular risk. The functional ABCA1/R230C variant frequent the Mexican population has been consistently associated with low concentrations. Although it other risk factors such as obesity type 2 diabetes mellitus, not whether coronary artery disease (CAD).The purpose of study was analyze premature CAD case-control association (GEA or Genetics Atherosclerotic Disease), explore BMI...
We studied HLA class I (HLA-A, -B) and II (HLA-DRB1, -DQB1) allele groups alleles by PCR-SSP based typing in a total of 15,318 mixed ancestry Mexicans from all the states country divided into 78 sample sets, providing information regarding allelic haplotypic frequencies their linkage disequilibrium, as well admixture estimates genetic substructure. identified presence 4268 unique extended haplotypes across Mexico find that ten most frequent (HF > 1%) with significant disequilibrium (Δ'≥0.1)...
Understanding the genetic structure of Native American populations is important to clarify their diversity, demographic history, and identify factors relevant for biomedical traits. Here, we show a history reconstruction from 12 whole genomes belonging six distinct ethnic groups representing three main described clusters Mexico (Northern, Southern, Maya). Effective population size estimates all remained below 2,000 individuals up 10,000 years ago. The proportion missense variants predicted...
Risk of hyperuricemia is modified by genetic and environmental factors. Our aim was to identify factors associated with serum uric acid levels in Mexicans. A pilot Genome-wide association study GWAS performed a subgroup participants (n = 411) from the Health Workers Cohort Study (HWCS). Single nucleotide polymorphisms (SNPs) were validated all HWCS 1939) replicated independent children 1080) adult 1073) case-control studies. The meta-analysis whole replication samples identified three SLC2A9...
Abstract Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from admixture between mainly Native American and European populations, we used genome-wide microarray, HLA high-resolution typing AQP4 gene sequencing data to analyze genetic ancestry seek variants conferring NMO susceptibility admixed patients. A total of 164 patients 1,208 controls were included. On average, had proportion than (68.1%...
SUMMARY The process of inhabiting the Americas by ancestral native American populations involved many individuals settling in Peruvian Andes and Amazonian regions. Due to Latin countries representing less than 1% human genome data available public reference databases, evolution migration processes adapting this unique geography have not yet been fully explained. Genome Project is an initiative, started 2011, address underrepresentation genomic from South populations. This project has...
Background/Objectives: Due to their work and lifestyle, many members of the university faculty, as well administrative staff students, are at risk developing health problems. These factors can be assessed find out contribution heart disease. The main objective this study is determine cardiovascular in a setting based on Framingham method. Methods: A quantitative approach, cross-sectional design, an observational descriptive level were used study. sample was made up 85 community, adapted...
Pacific Whiteleg shrimp (Litopenaeus vannamei) is an important model for breeding programs to improve global aquaculture productivity. However, the interaction between host genetics and microbiota in enhancing productivity remains poorly understood. We investigated effect of two genetic lines, Fast-Growth (Gen1) Disease-Resistant (Gen2), on L. vannamei. Using genome-wide SNP microarray analysis, we confirmed that Gen1 Gen2 represented distinct populations. After confirming rearing pond did...
Individual differences in cognitive performance are partly dependent, on genetic polymporhisms. One of the single-nucleotide polymorphisms (SNP) CNR1 gene, which codes for cannabinoid receptor 1 (CB1R), is rs2180619, located a regulatory region this gene (6q14-q15). The alleles rs2180619 A > G; G allele has been associated with addiction and high levels anxiety (when interacts SS genotype 5-HTTLPR gene). However, GG observed also healthy subjects. Considering as risk 'psychopathological...
Background Common variants rs6232 and rs6235 in the PCSK1 gene have been associated with obesity European populations. We aimed to evaluate contribution of these related traits Mexican children adults. Methodology/Principal Findings Rs6232 were genotyped 2382 individuals, 1206 1176 Minor allele frequencies 0.78% for 19.99% rs6235. was significantly childhood adult class III (OR = 3.01 95%CI 1.64–5.53; P 4×10−4 combined analysis). In addition, this SNP lower fasting glucose levels (P 0.01)...
Low HDL-C (high-density lipoprotein cholesterol) is the most frequent dyslipidemia in Mexicans, but few studies have examined underlying genetic basis. Our purpose was to identify variants associated with levels and cardiovascular risk Mexican population.A genome-wide association for 2335 identified four loci significance: CETP, ABCA1, LIPC, SIDT2. The SIDT2 missense Val636Ile variant replicated 3 independent cohorts (P=5.9×10−18 conjoint analysis). SIDT2/Val636Ile more Native American...
The presence of Y chromosome fragments in patients with Turner's syndrome is known to increase the risk gonadoblastoma and virilization. material detected up 6% by karyotype. By DNA analysis, sequences have been reported 0-60% patients. putative gene has mapped pericentromeric region increasing interest studying these sequences.1. To determine frequency occult syndrome. 2. analyze clinical implications karyotype sequences.Cross-sectional study 58 (30 45,X; two structural anomalies; 26 mosaic...