Tábita Hünemeier
A5047078365- Forensic and Genetic Research
- melanin and skin pigmentation
- Genetic Associations and Epidemiology
- Morphological variations and asymmetry
- Genetic and phenotypic traits in livestock
- dental development and anomalies
- Race, Genetics, and Society
- Skin Protection and Aging
- Genetic diversity and population structure
- Language and cultural evolution
- Forensic Anthropology and Bioarchaeology Studies
- Amazonian Archaeology and Ethnohistory
- Pleistocene-Era Hominins and Archaeology
- Genetic Mapping and Diversity in Plants and Animals
- Fish biology, ecology, and behavior
- Archaeology and ancient environmental studies
- Evolutionary Psychology and Human Behavior
- Cleft Lip and Palate Research
- Genomics and Phylogenetic Studies
- T-cell and B-cell Immunology
- Genomics and Rare Diseases
- Biochemical Analysis and Sensing Techniques
- Animal Genetics and Reproduction
- Craniofacial Disorders and Treatments
- Indigenous Studies and Ecology
Institut de Biologia Evolutiva
2022-2025
Universitat Pompeu Fabra
2022-2025
Universidade de São Paulo
2016-2025
Genomic (Brazil)
2020-2024
Universidade Federal do Rio Grande do Sul
2011-2022
Shanghai Institute of Nutrition and Health
2022
University of Chinese Academy of Sciences
2022
Universidade Cidade de São Paulo
2017-2018
The current genetic makeup of Latin America has been shaped by a history extensive admixture between Africans, Europeans and Native Americans, process taking place within the context geographic social stratification. We estimated individual ancestry proportions in sample 7,342 subjects ascertained five countries (Brazil, Chile, Colombia, México Perú). These individuals were also characterized for range physical appearance traits self-perception ancestry. distribution this reveals population...
Highlights•Genome-wide analysis of 49 Central and South Americans up to ∼11,000 years old•Two previously unknown genetic exchanges between North America•Distinct link a Clovis culture-associated genome the oldest Americans•Continent-wide replacement Clovis-associated ancestry beginning at least 9,000 agoSummaryWe report genome-wide ancient DNA from individuals forming four parallel time transects in Belize, Brazil, Andes, Southern Cone, each dating ∼9,000 ago. The common ancestral population...
Abstract We report a genome-wide association scan for facial features in ∼6,000 Latin Americans. evaluated 14 traits on an ordinal scale and found significant ( P values<5 × 10 −8 ) at single-nucleotide polymorphisms (SNPs) four genomic regions three nose-related traits: columella inclination (4q31), nose bridge breadth (6p21) wing (7p13 20p11). In subsample of ∼3,000 individuals we obtained quantitative related to 9 the phenotypes and, also, measure nasion position. Quantitative analyses...
Abstract We report a genome-wide association scan in over 6,000 Latin Americans for features of scalp hair (shape, colour, greying, balding) and facial (beard thickness, monobrow, eyebrow thickness). found 18 signals reaching significance ( P values 5 × 10 −8 to 3 −119 ), including novel associations. These include loci shape balding, the first reported beard thickness. A newly identified locus influencing includes Q30R substitution Protease Serine S1 family member 53 PRSS53 ). demonstrate...
Abstract We report a genome-wide association scan in >6,000 Latin Americans for pigmentation of skin and eyes. found eighteen signals at twelve genomic regions. These include one novel locus (in 10q26) three loci eye 1q32, 20q13 22q12). demonstrate the presence multiple independent 11q14 15q13 regions (comprising GRM5/TYR HERC2/OCA2 genes, respectively) several epistatic interactions among independently associated alleles. Strongest with 19p13 was observed an Y182H missense variant...
It has been suggested that the higher susceptibility of Hispanics to metabolic disease is related their Native American heritage. A frequent cholesterol transporter ABCA1 (ATP-binding cassette A1) gene variant (R230C, rs9282541) apparently exclusive individuals was associated with low high-density lipoprotein (HDL-C) levels, obesity and type 2 diabetes in Mexican Mestizos. We performed a more extensive analysis this 4405 Americans 863 from other ethnic groups investigate genetic evidence...
Historical records and genetic analyses indicate that Latin Americans trace their ancestry mainly to the intermixing (admixture) of Native Americans, Europeans Sub-Saharan Africans. Using novel haplotype-based methods, here we infer sub-continental in over 6,500 evaluate impact regional variation on physical appearance. We find American components correspond geographically present-day structure groups, sources non-Native ancestry, admixture timings, match documented migratory flows. also...
Here we report a genome-wide association study for non-pathological pinna morphology in over 5,000 Latin Americans. We find significant at seven genomic regions affecting: lobe size and attachment, folding of antihelix, helix rolling, ear protrusion antitragus (linear regression P values 2 × 10(-8) to 3 10(-14)). Four traits are associated with functional variant the Ectodysplasin A receptor (EDAR) gene, key regulator embryonic skin appendage development. confirm expression Edar developing...
Significance There is much interest in understanding the role of natural selection shaping physiological adaptations to climate, diet, and diseases humans. We investigated this issue by analyzing genomic data from Native American populations inhabiting different ecological regions ancient Americans. found signals at fatty acid desaturases ( FADS ) genes not only an Arctic population, as was previously found, but throughout Americas, suggesting a single strong adaptive event that occurred...
We carried out a genome-wide association study in Latin Americans and identified novel face morphology loci..
Different models have been proposed to elucidate the origins of founding populations America, along with number migratory waves and routes used by these first explorers. Settlements, both Pacific coast on land, evidenced in genetic archeological studies. However, origin immigrants are still controversial topics. Here, we show Australasian signal is present region, indicating a more widespread distribution within South America implicating an ancient contact between Amazonian dwellers. We...
Antisocial and criminal behaviors are multifactorial traits whose interpretation relies on multiple disciplines. Since these interpretations may have social, moral legal implications, a constant review of the evidence is necessary before any scientific claim considered as truth. A recent study proposed that men with wider faces relative to facial height (fWHR) more likely develop unethical behaviour mediated by psychological sense power. This research was based reports suggesting sexual...
The expression of facial asymmetries has been recurrently related with poverty and/or disadvantaged socioeconomic status. Departing from the developmental instability theory, previous approaches attempted to test statistical relationship between stress experienced by individuals grown in poor conditions and an increase corporal asymmetry. Here we aim further evaluate such hypothesis on a large sample admixed Latin Americans exploring if low status tend exhibit greater fluctuating asymmetry...
Abstract Throughout human evolutionary history, large-scale migrations have led to intermixing (i.e., admixture) between previously separated groups. Although classical and recent work shown that studying admixture can yield novel historical insights, the extent which this process contributed adaptation remains underexplored. Here, we introduce a statistical model, specific admixed populations, identifies loci under selection while determining whether likely occurred post-admixture or prior...
Abstract We analyzed sequence variation in the mitochondrial DNA (mtDNA) hypervariable segment I (HVS‐I) from 201 Black individuals two Brazilian cities (Rio de Janeiro and Porto Alegre), compared these data with published information 21 African populations. A subset of 187 males sample was also characterized for 30 Y‐chromosome biallelic polymorphisms, were those 48 The mtDNA indicated that respectively 69% 82% matrilineages found Rio Alegre originated West‐Central/Southeast Africa. These...
The "thrifty genotype" hypothesis proposes that the high prevalence of type 2 diabetes (T2D) in Native Americans and admixed Latin has a genetic basis reflects an evolutionary adaptation to past low calorie/high exercise lifestyle. However, identification gene variants underpinning this remains elusive. Here we assessed role American ancestry, socioeconomic status (SES) 21 candidate loci susceptibility T2D sample 876 cases 399 controls from Antioquia (Colombia). Although mean ancestry is...
Culture and genetics rely on two distinct but not isolated transmission systems. Cultural processes may change the human selective environment thereby affect which individuals survive reproduce. Here, we evaluated whether modes of subsistence in Native American populations frequencies ABCA1*Arg230Cys polymorphism were correlated. Further, examined evolutionary consequences agriculturally constructed niche Mesoamerica could be considered as a gene-culture coevolution model. For this purpose,...
In the 15th century, ∼900,000 Native Americans, mostly Tupí speakers, lived on Brazilian coast. By end of 18th coastal native populations were declared extinct. The arrived east coast after leaving Amazonian basin ∼2,000 y before present; however, there is no consensus how this migration occurred: toward northern Amazon and then directly to Atlantic coast, or heading south into continent migrating Here we leveraged genomic data from one last remaining putative representatives branch, a...
Abstract We report a genome-wide association study of facial features in >6000 Latin Americans based on automatic landmarking 2D portraits and testing for with inter-landmark distances. detected significant associations (P-value <5 × 10 −8 ) at 42 genome regions, nine which have been previously reported. In follow-up analyses, 26 the 33 novel regions replicate East Asians, Europeans, or Africans, one mouse homologous region influences craniofacial morphology mice. The 1q32.3 shows...
Abstract Native Americans are characterized by specific and unique patterns of genetic cultural/linguistic diversities, this information has been used to understand geographic dispersion, the relationship between these peoples. Particularly interesting Tupi Je speaker dispersions. At present, a large number individuals speak languages two stocks; for instance, Tupi‐Guarani is one official in Paraguay, Bolivia, Mercosul economic block. Although expansion can be compared importance Bantu...
Both modern humans (MHs) and Neanderthals successfully settled across western Eurasian cold-climate landscapes. Among the many adaptations considered as essential to survival in such landscapes, changes nasal morphology and/or function aimed humidify warm air before it reaches lungs are of key importance. Unfortunately, lack soft-tissue evidence fossil record turns difficult any comparative study respiratory performance. Here, we reconstruct internal cavity a Neanderthal plus two...
Ecological conditions in the Amazon rainforests are historically favorable for transmission of numerous tropical diseases, especially vector-borne diseases. The high diversity pathogens likely contributes to strong selective pressures human survival and reproduction this region. However, genetic basis adaptation complex ecosystem remains unclear. This study investigates possible footprints rainforest environment by analyzing genomic data 19 native populations. results based on functional...
Abstract Sambaqui (shellmound) societies are among the most intriguing archaeological phenomena in pre-colonial South America, extending from approximately 8,000 to 1,000 years before present (yr bp ) across 3,000 km on Atlantic coast. However, little is known about their connection early Holocene hunter-gatherers, how this may have contributed different historical pathways and processes through which late ceramists came rule coast shortly European contact. To contribute our understanding of...