Hortensia Moreno-Macías
A5046827968- Air Quality and Health Impacts
- Genetic Associations and Epidemiology
- Asthma and respiratory diseases
- Climate Change and Health Impacts
- Genetic and phenotypic traits in livestock
- Noise Effects and Management
- Pancreatic function and diabetes
- Birth, Development, and Health
- Health and Lifestyle Studies
- Metabolism, Diabetes, and Cancer
- Child Nutrition and Water Access
- Air Quality Monitoring and Forecasting
- Genetic Mapping and Diversity in Plants and Animals
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Glutathione Transferases and Polymorphisms
- Obesity, Physical Activity, Diet
- Heavy Metal Exposure and Toxicity
- Fatty Acid Research and Health
- Lipid metabolism and disorders
- Cancer-related molecular mechanisms research
- Genomics, phytochemicals, and oxidative stress
- Epigenetics and DNA Methylation
- Allergic Rhinitis and Sensitization
- Cancer Risks and Factors
- Nutritional Studies and Diet
Universidad Autónoma Metropolitana
2015-2025
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2012-2023
Universidad Nacional Autónoma de México
2012-2017
Instituto Nacional de Salud Pública
2002-2010
National Oceanic and Atmospheric Administration
2008
Autonomous University of San Luis Potosí
2005
National Center for Environmental Health
2004
Environmental Protection Agency
2002
Hospital Infantil de México Federico Gómez
2002
<h3>Importance</h3> Latino populations have one of the highest prevalences type 2 diabetes worldwide. <h3>Objectives</h3> To investigate association between rare protein-coding genetic variants and prevalence in a large population to explore potential molecular physiological mechanisms for observed relationships. <h3>Design, Setting, Participants</h3> Whole-exome sequencing was performed on DNA samples from 3756 Mexican US individuals (1794 with 1962 without diabetes) recruited 1993 2013....
Latin America continues to be severely underrepresented in genomics research, and fine-scale genetic histories complex trait architectures remain hidden owing insufficient data1. To fill this gap, the Mexican Biobank project genotyped 6,057 individuals from 898 rural urban localities across all 32 states Mexico at a resolution of 1.8 million genome-wide markers with linked disease information creating valuable nationwide genotype-phenotype database. Here, using ancestry deconvolution...
To evaluate whether acute effects of ozone, nitrogen dioxide, and particulates with mass median diameter less than 10 micro m could be attenuated by antioxidant vitamin supplementation, we conducted a randomized trial using double-blinded design. Children asthma (n = 158) who were residents Mexico City randomly given daily supplement vitamins (50 mg/day E 250 C) or placebo followed from October 1998 to April 2000. Pulmonary function tests carried out twice week in the morning. During...
Although short-term exposure to air pollution has been associated with acute, reversible lung function decrements, the impact of long-term not well established.To evaluate association between ozone (O(3)), particulate matter less than 10 mum in diameter (PM(10)), and nitrogen dioxide (NO(2)) growth Mexico City schoolchildren.A dynamic cohort 3,170 children aged 8 years at baseline was followed from April 23, 1996, through May 19, 1999. The attended 39 randomly selected elementary schools...
We analyze the strength of association between aerosol optical depth (AOD) retrievals from GOES aerosol/smoke product (GASP) and ground-level fine particulate matter (PM2.5) to assess AOD as a proxy for PM2.5 in United States. GASP is retrieved geostationary platform, giving half-hourly observations every day, contrast once per day snapshots polar-orbiting satellites. However, based on less-sophisticated instrument retrieval algorithm. find that daily correlations over time at fixed...
Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and adults personal smoking. Whether a unique signature exists for
Acute exposure to ozone has been related a wide spectrum of health effects in susceptible individuals. Genetic factors may influence interindividual variation response. The current authors investigated the relationships between common polymorphisms two genes involved response oxidative stress, i.e. glutathione S-transferases M1 (GSTM1) and P1 (GSTP1), both respiratory symptoms lung function among childhood asthmatics. A total 151 asthmatic children, who were participants randomised...
Several studies have identified nearly 40 different type 2 diabetes susceptibility loci, mainly in European populations, but few of them been evaluated the Mexican population. The aim this study was to examine extent which 24 common genetic variants previously associated with are Mestizos. Twenty-four single nucleotide polymorphisms (SNPs) or near genes (KCNJ11, PPARG, TCF7L2, SLC30A8, HHEX, CDKN2A/2B, CDKAL1, IGF2BP2, ARHGEF11, JAZF1, CDC123/CAMK1D, FTO, TSPAN8/LGR5, KCNQ1, THADA, ADAMTS9,...
Epidemiological and physiological similarities among Gestational Diabetes Mellitus (GDM) Type 2 (T2D) suggest that both diseases, share a common genetic background. T2D risk variants have been associated to GDM susceptibility. However, the architecture of is not yet completely understood. We analyzed 176 SNPs for 115 loci previously T2D, body mass index (BMI), as well set 118 Ancestry Informative Markers (AIMs), in 750 pregnant Mexican women. Association with was found two most frequently...
Introduction Severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) infection triggers inflammatory clinical stages that affect the outcome of patients with coronavirus disease 2019 (COVID-19). Disease severity may be associated a metabolic imbalance related to amino acids, lipids, and energy-generating pathways. The aim this study was characterize profile acids acylcarnitines in COVID-19 patients. A multicenter, cross-sectional carried out. total 453 individuals were classified by...
SUMMARY The inflammatory response to ozone in atopic asthma suggests that soluble mediators of inflammation are released oxidant stress. Antioxidants may alleviate additional oxidative stress associated with photochemical pollution. This study investigates the impact antioxidant supplementation on nasal exposure asthmatic children. We conducted a randomized trial using double-blinded design. Children (n = 117), residents Mexico City, were given randomly daily supplement vitamins (50 mg/day...
Abstract Background Taffic-related air pollution has been related to adverse respiratory outcomes; however, there is still uncertainty concerning the type of vehicle emission causing most deleterious effects. Methods A panel study was conducted among 147 asthmatic and 50 healthy children, who were followed up for an average 22 weeks. Incidence density coughing, wheezing breathing difficulty assessed by referring daily records symptoms child's medication. The association between exposure...
Section:ChooseTop of pageAbstract <<SUSCEPTIBILITY TO PULMONA...ADVERSE EFFECTS OF AIR PO...EPIDEMIOLOGIC EVIDENCE OF...IMPLICATION GENETIC ST...CONCLUSIONSReferencesCITING ARTICLES
Type 2 diabetes (T2D) affects more than 415 million people worldwide, and its costs to the health care system continue rise. To identify common or rare genetic variation with potential therapeutic implications for T2D, we analyzed replicated genome-wide protein coding in a total of 8,227 individuals T2D 12,966 without Latino descent. We identified novel variant IGF2 gene associated ∼20% reduced risk T2D. This variant, which has an allele frequency 17% Mexican population but is Europe,...
Genome-wide association studies (GWAS) have identified 58 susceptibility alleles across 37 regions associated with the risk of colorectal cancer (CRC) P < 5×10−8. Most been conducted in non-Hispanic whites and East Asians; however, generalizability these findings potential for ethnic-specific variation Hispanic Latino (HL) individuals largely understudied. We describe first GWAS common genetic contributing to CRC HL (1611 cases 4330 controls). also examine known implement imputation-based...
The nuclear factor‐erythroid 2‐ (NF‐E2‐) related factor 2 (Nrf2) is abated and its ability to reduce oxidative stress impaired in type diabetes obesity. Thus, the aim of this study was explore if polymorphisms Nrf2 target genes are associated with obesity Mexican mestizo subjects. rs1800566 NAD(P)H:quinone oxidoreductase 1 (NQO1) gene, rs7211 thioredoxin interacting protein (TXNIP) rs2071749 heme oxygenase‐1 (HMOX1) rs6721961 rs2364723 from gene were genotyped 627 diabetic subjects 1020...
Lead (Pb), mercury (Hg), and manganese (Mn) are neurotoxic, but little is known about the neurodevelopmental effects associated with simultaneous prenatal exposure to these metals. We aimed study associations of Pb, Hg, Mn levels (jointly separately) neurodevelopment in first year life. Methods: blood lead were measured 253 pregnant women. Their offspring’s was assessed through Bayley Scale Infant Development III® at one, three, six, twelve months. The metals’ mean (µg/L) Pb = 11.2, Hg 2.1,...
Concerning the genetic factors of obesity, no consistent association between populations has been reported, which may be due to frequency polymorphisms, lifestyle studied and its interaction with other factors. We a possible polymorphisms FTO rs9939609, PPARG rs1801282, ADIPOQ rs4632532 rs182052 obesity phenotypes in 215 Mexican children. Glucose, triglycerides, cholesterol, HDL LDL were measured. In addition, weight, height, waist circumference triceps skin thickness recorded. High-energy...