Akram Ghantous
A5055853484- Epigenetics and DNA Methylation
- Birth, Development, and Health
- Health, Environment, Cognitive Aging
- Sesquiterpenes and Asteraceae Studies
- Air Quality and Health Impacts
- Cancer-related gene regulation
- Nitrogen and Sulfur Effects on Brassica
- Neonatal Respiratory Health Research
- RNA modifications and cancer
- Childhood Cancer Survivors' Quality of Life
- Energy and Environment Impacts
- Esophageal Cancer Research and Treatment
- Acute Lymphoblastic Leukemia research
- Radiomics and Machine Learning in Medical Imaging
- Synthesis and Biological Activity
- Gestational Diabetes Research and Management
- Plant Toxicity and Pharmacological Properties
- Molecular Biology Techniques and Applications
- Effects and risks of endocrine disrupting chemicals
- Cancer Genomics and Diagnostics
- NF-κB Signaling Pathways
- Child Nutrition and Water Access
- Digestive system and related health
- Synthetic Organic Chemistry Methods
- Histone Deacetylase Inhibitors Research
Centre international de recherche sur le cancer
2016-2025
Johns Hopkins University
2022
Berkeley Public Health Division
2022
University of California, Berkeley
2022
American University of Beirut
2008-2021
American University of Beirut Medical Center
2020
World Health Organization
2019
PharmacoGenetics (China)
2015
Lebanese American University
2013-2014
Laboratory of Molecular Genetics
2014
Aim: Epigenetic changes may occur in response to environmental stressors, and an altered epigenome pattern represent a stable signature of exposure. Materials & methods: Here, we examined the potential DNA methylation 910 prediagnostic peripheral blood samples as marker exposure tobacco smoke large multinational cohort. Results: We identified 748 CpG sites that were differentially methylated between smokers nonsmokers, among which novel regionally clustered CpGs associated with active...
Abstract Malignant pleural mesothelioma (MPM) is an aggressive cancer with rising incidence and challenging clinical management. Through a large series of whole-genome sequencing data, integrated transcriptomic epigenomic data using multiomics factor analysis, we demonstrate that the current World Health Organization classification only accounts for up to 10% interpatient molecular differences. Instead, MESOMICS project paves way morphomolecular MPM based on four dimensions: ploidy, tumor...
Author(s): Felix, Janine F; Joubert, Bonnie R; Baccarelli, Andrea A; Sharp, Gemma C; Almqvist, Catarina; Annesi-Maesano, Isabella; Arshad, Hasan; Baiz, Nour; Bakermans-Kranenburg, Marian J; Bakulski, Kelly M; Binder, Elisabeth B; Bouchard, Luigi; Breton, Carrie V; Brunekreef, Bert; Brunst, Burchard, Esteban G; Bustamante, Mariona; Chatzi, Leda; Cheng Munthe-Kaas, Monica; Corpeleijn, Eva; Czamara, Darina; Dabelea, Dana; Davey Smith, George; De Boever, Patrick; Duijts, Liesbeth; Dwyer,...
OBJECTIVE Maternal gestational diabetes mellitus (GDM) has been associated with adverse outcomes in the offspring. Growing evidence suggests that epigenome may play a role, but most previous studies have small and adjusted for few covariates. The current study meta-analyzed association between maternal GDM cord blood DNA methylation Pregnancy Childhood Epigenetics (PACE) consortium. RESEARCH DESIGN AND METHODS Seven pregnancy cohorts (3,677 mother-newborn pairs [317 GDM]) contributed results...
Monozygotic twins have long been studied to estimate heritability and explore epigenetic influences on phenotypic variation. The similarities of monozygotic assumed be largely due their genetic identity. Here, by analyzing data from a genome-scale study DNA methylation in dizygotic twins, we identified genomic regions at which the similarity is substantially greater than can explained This "epigenetic supersimilarity" apparently results locus-specific establishment epigenotype prior embryo...
Air pollution is associated with a broad range of adverse health effects, including mortality and morbidity due to cardio‐ cerebrovascular diseases (CCVD), but the molecular mechanisms involved are not entirely understood. This study aims investigate involvement oxidative stress inflammation in causal chain, identify intermediate biomarkers that retrospectively exposure prospectively disease. We designed case‐control on CCVD nested cohort 18,982 individuals from EPIC‐Italy study. measured...
Epidemiologic evidence indicates common risk factors, including air pollution exposure, for respiratory and cardiovascular diseases, suggesting the involvement of altered molecular pathways.
Cigarette smoking influences DNA methylation genome wide, in newborns from pregnancy exposure and adults personal smoking. Whether a unique signature exists for
Background: Few epigenome-wide association studies (EWAS) on air pollutants exist, and none have been done transportation noise exposures, which also contribute to environmental burden of disease. Objective: We performed mutually independent EWAS pollution exposures. Methods: used data from two time points the Swiss Cohort Study Air Pollution Lung Heart Diseases in Adults (SAPALDIA) 1,389 participants contributing 2,542 observations. applied multiexposure linear mixed-effects regressions...
The 10 key characteristics (KCs) of carcinogens form the basis a framework to identify, organize, and evaluate mechanistic evidence relevant carcinogenic hazard identification. KCs are related mechanisms by which cause cancer. International Agency for Research on Cancer (IARC) Monographs programme has successfully applied evaluation different types exposures, including chemicals, metals, complex such as environmental, occupational, or dietary exposures. use this significantly enhanced...
Socioeconomic experiences are recognized determinants of health, and recent work has shown that social disadvantages in early life may induce sustained biological changes at molecular level detectable later life. However, the dynamics persistence embedding socioeconomic position (SEP) remains vastly unexplored.
Abstract Establishing causal relationship between epigenetic marks and gene transcription requires molecular tools, which can precisely modify specific genomic regions. Here, we present a modular extensible CRISPR/dCas9-based toolbox for editing direct regulation. It features system expression of orthogonal dCas9 proteins fused to various effector domains includes multi-gRNA simultaneous targeting orthologs up six loci. The C- N-terminal fusions with DNMT3A TET1 catalytic were thoroughly...
Abstract Epigenetic mechanisms such as aberrant DNA methylation (DNAme) are known to drive esophageal squamous cell carcinoma (ESCC), yet they remain poorly understood. Here, we studied tumor-specific DNAme in ESCC cases from nine high-incidence countries of Africa, Asia, and South America. Infinium MethylationEPIC array was performed on 108 tumors 51 normal tissues adjacent the (NAT) discovery phase, targeted pyrosequencing 132 36 NAT replication phase. Top genes for were prioritized by...