A5078787117- Carcinogens and Genotoxicity Assessment
- Effects and risks of endocrine disrupting chemicals
- Estrogen and related hormone effects
- Reproductive Biology and Fertility
- Animal Behavior and Welfare Studies
- Thyroid Disorders and Treatments
- Geomagnetism and Paleomagnetism Studies
- Toxic Organic Pollutants Impact
- Heavy Metal Exposure and Toxicity
- Geophysics and Gravity Measurements
- Pregnancy and preeclampsia studies
- Neurogenetic and Muscular Disorders Research
- Dye analysis and toxicity
- Animal testing and alternatives
- Growth Hormone and Insulin-like Growth Factors
- Cancer-related molecular mechanisms research
- Solar and Space Plasma Dynamics
- Ionosphere and magnetosphere dynamics
- Genetic and phenotypic traits in livestock
- Cardiovascular Health and Disease Prevention
- Animal Nutrition and Physiology
- Circular RNAs in diseases
- Bat Biology and Ecology Studies
- Cosmology and Gravitation Theories
- Cancer-related gene regulation
Mitchell Institute
2025
Texas A&M University
2019-2025
Centre International de Recherche sur le Cancer
2023
University of Sannio
2015-2019
Biogem
2015-2017
University of Naples Federico II
1984-2010
University of Campania "Luigi Vanvitelli"
2010
The 10 key characteristics (KCs) of carcinogens form the basis a framework to identify, organize, and evaluate mechanistic evidence relevant carcinogenic hazard identification. KCs are related mechanisms by which cause cancer. International Agency for Research on Cancer (IARC) Monographs programme has successfully applied evaluation different types exposures, including chemicals, metals, complex such as environmental, occupational, or dietary exposures. use this significantly enhanced...
Abstract Epidemiologic and experimental studies have associated changes of blood glucose homeostasis to Bisphenol A (BPA) exposure. We took a toxicogenomic approach investigate the mechanisms low-dose (1 × 10 −9 M) BPA toxicity in ex vivo cultures primary murine pancreatic islets hepatocytes. Twenty-nine inhibited genes were identified none exposed Although their expression was slightly altered, impaired cellular level, as whole, resulted specific phenotypic changes. Damage mitochondrial...
Estrogen receptor alpha (ERalpha) is a modular protein of the steroid/nuclear family transcriptional regulators that upon binding to hormone undergoes structural changes, resulting in its nuclear translocation and docking specific chromatin sites. In nucleus, ERalpha assembles multiprotein complexes act as final effectors estrogen signaling genome through remodeling epigenetic modifications, leading dynamic coordinated regulation hormone-responsive genes. Identification molecular partners...
Epidemiological and experimental data highlighted the thyroid-disrupting activity of bisphenol A (BPA). Although pivotal to identify mechanisms toxicity, direct low-dose BPA effects on thyrocytes have not been assessed. Here, we report results microarray experiments revealing that transcriptome reacts dynamically exposure, adapting changes in gene expression exposure duration. The response involves many genes, enriching specific pathways biological functions mainly cell death/proliferation...
Abstract Contemporary approaches for developing interventions and assessing pre-clinical cardiovascular risk frequently utilize animal in vitro models. However, these models currently lack normal species-specific reference ranges similar to what exists humans. The genetically diverse Collaborative Cross (CC) population that human genetic heterogenetiety was characterized develop mouse-specific cardiac Mus muscuslus , the most commonly used pre-clincial model. Heart function analyzed males...
Abstract Breastfeeding offers well-documented advantages but may inadvertently introduce lead (Pb) exposure to infants. Scarce data exists on the risks of Pb for breastfed infants, and strategies risk mitigation are needed, particularly considering heightened susceptibility children adverse effects from exposure. To investigate potential influence breastfeeding blood levels (BLL) in offspring, population variation BLL between non-parous parous mouse dams was quantified, as well exposed low-...
The progressive and physiological decline in ovarian function depends on the rate of follicular loss by atresia, contributing to reduction reserve. Genetics environmental factors play important roles senescence onset dysfunctions such as diminished A better understanding mechanisms underlying aging their regulation genetic is needed evaluate reserve predict fertility potential identification more accurate less invasive markers. We report transcriptomic data (i) implicating novel (e.g. EIF2...
Epidemiological and experimental studies emphasize the link between environmental chemicals exposure thyroid cancer. However, this association is strongly debated mechanisms of action carcinogens still need to be identified. The analysis in vitro transcriptomic data developed investigate effects chlorpyrifos on immortalized thyrocytes highlighted impaired expression genes involved endodermal carcinogenesis. This carcinogenic gene-network (ECGN, including Zfp36l2, Dmbt1, Ddit4), was validated...
Although the imbalance of circulating levels Thyroid Hormones (THs) affects female fertility in vertebrates, its involvement promotion Premature Ovarian Aging (POA) is debated. Therefore, altered synthesis THs both thyroid and ovary can be a trait POA. We investigated relationship between abnormal TH signaling, dysthyroidism, POA evolutionary distant vertebrates: from zebrafish to humans. T3 signaling/metabolism was evaluated by measuring levels, responsive transcript, protein along with...
Abstract Blood lead (Pb) level (BLL) is a commonly used biomarker to evaluate associations with health effects. However, interventions reduce the adverse effects of Pb require relating BLL external exposure. Moreover, risk mitigation actions need ensure protection more susceptible individuals greater tendency accumulate Pb. Because little data available quantify inter-individual variability in biokinetics Pb, we investigated influence genetics and diet on genetically diverse Collaborative...
Abstract BackgroundBeta-catenin (CTNNB1) is a key downstream effector of the WNT signaling pathway that involved in embryonic development and tumorigenesis. To further study role CTNNB1 gut tumorigenesis, mice carrying conditional, stabilizing mutation Ctnnb1 ( tm1Mmt ) were crossed with expressing CRE recombinase under intestinal epithelial Villin 1 promoter Vil1-Cre ).ResultsContrary to expectations, no double heterozygous , observed at birth, suggesting lethality. After assessment timing...