A5020365483- SARS-CoV-2 and COVID-19 Research
- Antimicrobial Peptides and Activities
- Antibiotic Resistance in Bacteria
- COVID-19 Clinical Research Studies
- Essential Oils and Antimicrobial Activity
- Nanoparticles: synthesis and applications
- Bacterial biofilms and quorum sensing
- Respiratory viral infections research
- Histone Deacetylase Inhibitors Research
- Epigenetics and DNA Methylation
- Bacterial Identification and Susceptibility Testing
- Herpesvirus Infections and Treatments
- Protein Degradation and Inhibitors
- Antimicrobial Resistance in Staphylococcus
- Pneumonia and Respiratory Infections
- Long-Term Effects of COVID-19
- Ocular Diseases and Behçet’s Syndrome
- Oral microbiology and periodontitis research
- Ocular Infections and Treatments
- Gut microbiota and health
- Bacterial Infections and Vaccines
- RNA Interference and Gene Delivery
- Viral Infections and Vectors
- Hepatitis C virus research
- Antibiotic Use and Resistance
University of Salerno
2020-2025
Ospedali Riuniti San Giovanni di Dio e Ruggi d'Aragona
2020-2025
Ospedale Madonna Delle Grazie
2024
University of Campania "Luigi Vanvitelli"
2010-2024
University of Molise
2024
University of Naples Federico II
2008-2018
Centro Interuniversitario di Ricerca sui Peptidi Bioattivi
2017-2018
Federico II University Hospital
2017
Naples Anesthesia & Physician Associates
2017
Istituto Nazionale di Fisica Nucleare, Sezione di Napoli
2010-2015
ABSTRACT The herpes simplex virus 1 (HSV-1) is widespread in the population, and most cases its infection asymptomatic. currently available anti-HSV-1 drugs are acyclovir derivatives, although long-term therapy with these agents can lead to drug resistance. Thus, discovery of novel antiherpetic compounds deserves additional effort. Naturally occurring antimicrobial peptides (AMPs) represent an interesting class molecules potential antiviral properties. To best our knowledge, this study first...
Healthcare-associated infections resulting from bacterial attachment and biofilm formation on medical implants are posing significant challenges in particular with the emergence of resistance to antibiotics. Here, we report design, synthesis characterization self-assembled nanostructures, which integrate their surface antibacterial peptides. The WMR peptide, is a modification native sequence myxinidin, marine peptide isolated epidermal mucus hagfish, was used considering its enhanced...
The COVID-19 pandemic has reached direct and indirect medical social consequences with a subset of patients who rapidly worsen die from severe-critical manifestations. As result, there is still an urgent need to identify prognostic biomarkers effective therapeutic approaches. Severe-critical manifestations are caused by dysregulated immune response. Immune checkpoint molecules such as Programmed death-1 (PD-1) its ligand programmed death-ligand 1 (PD-L1) play important role in regulating the...
Vitis vinifera represents an important and renowned source of compounds with significant biological activity. Wines winery bioproducts, such as grape pomace, skins, seeds, are rich in bioactive against a wide range human pathogens, including bacteria, fungi, viruses. However, little is known about the properties vine leaves. The aim this study was evaluation phenolic composition antiviral activity leaf extract two viruses: Herpes simplex virus type 1 (HSV-1) pandemic currently widespread...
Gram-negative bacteria release Outer Membrane Vesicles (OMVs) into the extracellular environment. Recent studies recognized these vesicles as vectors to horizontal gene transfer; however, parameters that mediate OMVs transfer within bacterial communities remain unclear. The present study highlights for first time of plasmids containing resistance genes via derived from Klebsiella pneumoniae (K. pneumoniae). This mechanism confers DNA protection, it is plasmid copy number dependent with a...
The COVID-19 pandemic has evidenced the urgent need for discovery of broad-spectrum antiviral therapies that could be deployed in case future emergence novel viral threats, as well to back up current therapeutic options drug resistance development. Most antivirals are directed inhibit specific viruses since these molecules designed act on a target with objective interfering precise step replication cycle. Therefore, antimicrobial peptides (AMPs) have been identified promising agents help...
The World Health Organization (WHO) estimates that the prevalence of human papillomaviruses (HPV) infection is between 9% and 13% world population only in United States, more than 6.2 million are positive every year. There 100 types HPV, among them, two serotypes (16 18) related to 70% cervical cancers precancerous lesions. vaginal microbiota could play a considerable role HPV genesis tumors caused by HPV. Moreover, bacteria strongly associated with inflammation oncogenic mutations cells. We...
Viral infections represent a serious threat to the world population and are becoming more frequent. The search identification of broad-spectrum antiviral molecules is necessary ensure new therapeutic options, since there limited availability effective drugs able eradicate viral infections, consequently due increase strains that resistant most used drugs. Recently, several studies on antimicrobial peptides identified them as promising agents. In detail, amphibian skin secretions serve rich...
Root canal treatment represents a significant challenge as current cleaning and disinfection methodologies fail to remove persistent bacterial biofilms within the intricate anatomical structures. Recently, field of nanotechnology has emerged promising frontier with numerous biomedical applications. Among most notable contributions are nanoparticles, which possess antimicrobial, antifungal, antiviral properties. Nanoparticles cause destructuring walls, increasing permeability cell membrane,...
Abstract Efficient predictive biomarkers are needed for immune checkpoint inhibitor (ICI)-based immunotherapy in non-small cell lung cancer (NSCLC). Testing the value of single nucleotide polymorphisms (SNPs) programmed death 1 ( PD-1 ) or its ligand PD-L1 has shown contrasting results. Here, we aim to validate SNPs advanced NSCLC patients treated with ICIs as well define molecular mechanisms underlying role identified SNP candidate. rs822336 efficiently predicted response anti-PD-1/PD-L1...
Metal and metal oxide nanostructured materials have been chemically physically characterized tested concerning methylene blue (MB) photoremoval UV antibacterial activity against Escherichia coli Staphylococcus aureus. In detail, silver nanoparticles commercial BaTiO3 were modified to obtain nanocomposites through sonicated sol-gel TiO2 synthesis the photodeposition of Ag nanoparticles, respectively. The characterization results pristine nanomaterials synthetized photocatalysts revealed...
Different mechanisms for CBFβ–MYH11 function in acute myeloid leukemia with inv(16) have been proposed such as tethering of RUNX1 outside the nucleus, interference transcription factor complex assembly and recruitment histone deacetylases, all resulting transcriptional repression target genes. Here, through genome-wide CBFβ–MYH11-binding site analysis quantitative interaction proteomics, we found that localizes to occupied promoters, where it interacts TAL1, FLI1 TBP-associated factors...
Background: Capsular contracture around breast implants is a severe and unpredictable complication experienced by up to 50 percent of patients after augmentation reconstruction, represents major cause leading reoperation. Several lines evidence point the involvement subclinical infections bacterial biofilm formation. Methods: To reduce incidence capsular following mammaplasty, authors studied correlation between contamination exogenous endogenous flora capacity develop in mammary implants....
Urinary tract infections (UTIs) are the most common and expensive health problem globally. The treatment of UTIs is difficult owing to onset antibiotic-resistant bacterial strains. aim this study was define incidence infections, identify bacteria responsible, antimicrobial resistance profile. Patients all ages both sexes were included in study, admitted University Hospital Campania "Luigi Vanvitelli", between January 2017 December 2018. Bacterial identification antibiotic susceptibility...
Bloodstream infections (BSIs) are among the leading causes of morbidity and mortality worldwide, infectious diseases. Local knowledge main bacteria involved in BSIs their associated antibiotic susceptibility patterns is essential to rationalize empiric antimicrobial therapy. The aim this study was define incidence infection evaluate resistance profile pathogens BSIs. This enrolled patients all ages both sexes admitted University Hospital “San Giovanni di Dio e Ruggi d’Aragona”, Salerno,...