The chili pepper is a very important plant used worldwide as vegetable, spice, and an external medicine. In this work, eight different varieties of Capsicum annuum L. have been characterized by their capsaicinoids content. fruits were cultivated in the Comarca Lagunera region North Mexico. qualitative quantitative determination major minor capsaicinoids; alkaloids responsible for pungency level, has performed validated chromatographic procedure (HPLC-DAD) after preliminary drying step...

Direct spectrophotometric determination of capsaicinoids content in Chiltepin pepper was investigated as a possible alternative to HPLC analysis. Capsaicinoids were extracted from red ripe and green fruit with acetonitrile evaluated quantitatively using the method capsaicin dihydrocapsaicin standards. Three samples different treatment analyzed for their successfully by these methods. HPLC-DAD revealed that capsaicin, dihydrocapsaicin, nordihydrocapsaicin comprised up 98% total detected. The...

Rattlesnake venoms may be classified according to the presence/absence and relative abundance of neurotoxic phospholipases A 2 s (PLA s), such as Mojave toxin, snake venom metalloproteinases (SVMPs). In Mexico, studies determine variation in Rattlesnakes (Crotalus scutulatus scutulatus) are limited little is known about biological proteolytic activities this species. Tissue (34) (29) samples were obtained from C. s. different locations within their distribution Mexico. toxin detection was...

Ontogenetic changes in venom composition have important ecological implications due the relevance of prey acquisition and defense. Additionally, intraspecific variation has direct medical consequences for treatment snakebite. However, ontogenetic are not well documented most species. The Mexican Black-tailed Rattlesnake (Crotalus molossus nigrescens) is large-bodied broadly distributed Mexico. To document test composition, we obtained samples from twenty-seven C. m. nigrescens with different...

Breast cancer is associated to estrogen exposure. Allelic variants involved in metabolism might change the risk of developing this neoplasia. We examined potential association breast Mexican women with polymorphisms CYP1A1 rs1048943, CYP1B1 rs1056836, COMT rs4680, GSTP1 rs1695, GSTT1 null and GSTM1 which are pathway. This study included 150 cases controls. A significant was observed between, rs1048943 (OR = 1.95, C.I. 1.13-3.36) rs1695 2.39, 1.24-4.24) cancer. increased when were stratified...

Concerning the genetic factors of obesity, no consistent association between populations has been reported, which may be due to frequency polymorphisms, lifestyle studied and its interaction with other factors. We a possible polymorphisms FTO rs9939609, PPARG rs1801282, ADIPOQ rs4632532 rs182052 obesity phenotypes in 215 Mexican children. Glucose, triglycerides, cholesterol, HDL LDL were measured. In addition, weight, height, waist circumference triceps skin thickness recorded. High-energy...

Abstract Background and purpose Smoking is a major public health problem worldwide. Polymorphisms in CHRNA3 , CHRNA5 CHRNB4 receptors play critical role nicotine dependence, lung cancer (LC) risk, chronic obstructive pulmonary disease (COPD). This study characterized the rs1051730 rs16969968 polymorphisms Mexican population its association with LC, COPD. Methods The included 312 healthy individuals, 74 LC cases 117 COPD cases. Genotyping was performed using TaqMan probes, data were analyzed...

Lung cancer is the leading cause of mortality in Mexico and worldwide. In past decade, there has been an increase number lung cases young people, which suggests important role for genetic background etiology this disease. study, we genetically characterized 16 polymorphisms 12 low penetrance genes (AhR, CYP1A1, CYP2E1, EPHX1, GSTM1, GSTT1, GSTPI, XRCC1, ERCC2, MGMT, CCND1 TP53) 382 healthy Mexican Mestizos as first step elucidating structure population identifying high risk individuals. All...

Nitrates in drinking water has been associated to adverse health effects, including changes glucose and lipid levels, thyroid hormone imbalance reproductive effects. We analyzed metabolic alterations genotoxic damage women with chronic exposure nitrates water. The concentration of was quantified according this parameter, participants were divided into three scenarios. Blood urine samples collected from 420 living Durango, Mexico biomarkers determined. found concentrations above the...

Cytochrome 1A1 (CYP1A1), glutathione transferase M1 (GSTM1), and T1 (GSTT1) catalyze the bioactivation detoxification of a wide variety xenobiotic compounds that are mutagenic and/or carcinogenic (e.g., polycyclic aromatic hydrocarbons). Genetic polymorphisms these metabolizing enzymes have been shown to affect individual susceptibility environmental compounds. Although several studies published on relationship between CYP1A1*2C, GSTM1*0, or GSTT1*0 polymorphism cancer, not all findings can...

Introduction: Pseudomonas aeruginosa is the second most prevalent opportunistic pathogen causing nosocomial infections in Mexico. This study evaluated antibiotic resistance, production of virulence factors and clonal diversity P. strains isolated from patients undergoing public hospitals northeastern Mexico.
 Methodology: Ninety-two isolates urine culture, Foley catheter, ear, wounds, respiratory tract secretions, scalp, blood bronchoalveolar lavage, expectoration cerebrospinal fluid...

Nitrate is a widely disseminated water pollutant and has been linked to health disorders, including hypothyroidism. Here, we evaluated the relationship between thyroid function chronic exposure nitrates in rural zone families, addition genetic autoimmune factors. Exposure effect biomarkers, hormones, autoantibodies of tiroperoxidase were measured, as well presence two FOXE1 polymorphisms (rs965513, rs1867277). Pearson’s correlation, principal component analysis, Kruskal–Wallis, chi-squared...

O6-Methylguanine-DNA methyltransferase (MGMT) is an enzyme that repairs the DNA damage caused by tobacco habit, and low activity of this has been associated with a risk lung cancer (LC). Our objective was to determine association promoter methylation rs12917 polymorphism MGMT formation bulky adducts LC in Mexican Mestizo population. In study are included 431 subjects. High-resolution melting analysis used levels. were determined 32P-postlabeling. results showed higher levels LC. The related...

Introduction: Hypertensive disorders are of interest in obstetrics and gynecology because they the second place among causes maternal mortality a source complications short, mid, long term. Even if pathophysiological process behind preeclampsia (PE) is still unknown, stress factors have been revealed to play an important role genesis this pathologic process. Methods: A case-control study was designed with purpose determining there differential methylation NR3C1, HSD11B2, CYP11A1, CRHBP,...

The Chihuahuan Desert is considered a site of high biodiversity; however, few studies have focused on the vascular flora in local areas. This study presents floristic inventory and an analysis richness biogeographic regionalization Comarca Lagunera northern Mexico from compilation historical records obtained literature, database National Biodiversity Information System Mexico, assessment herbarium specimens field collections. We documented 1174 species plants corresponding to approximately...