A5091169244- Arsenic contamination and mitigation
- Heavy Metal Exposure and Toxicity
- Heavy metals in environment
- Fluoride Effects and Removal
- Environmental Justice and Health Disparities
- Carcinogens and Genotoxicity Assessment
- Heme Oxygenase-1 and Carbon Monoxide
- Neonatal Health and Biochemistry
- Porphyrin Metabolism and Disorders
- Dye analysis and toxicity
- Trace Elements in Health
- Mercury impact and mitigation studies
- Child Nutrition and Water Access
- Selenium in Biological Systems
- Glutathione Transferases and Polymorphisms
- Birth, Development, and Health
- Air Quality and Health Impacts
- Environmental Toxicology and Ecotoxicology
- Pesticide Exposure and Toxicity
- Water Quality and Pollution Assessment
- Immunotoxicology and immune responses
- Per- and polyfluoroalkyl substances research
- Climate Change and Health Impacts
- Liver Disease Diagnosis and Treatment
- Health, Environment, Cognitive Aging
Universidad Juárez del Estado de Durango
2014-2024
Secretaria de Salud
2014-2015
Autonomous University of Durango
2011-2014
Secretaria de Salud
2014
Autonomous University of Chihuahua
2012
University of Nebraska Medical Center
2012
Indiana University School of Medicine
2005-2011
Universidad La Salle
2007
Universidad Autónoma de Coahuila
2002-2007
Instituto Politécnico Nacional
1991-2003
Previous studies have suggested an effect of high arsenic concentration on cognitive and neurobehavioral function in humans.
Chronic exposure to inorganic arsenic (iAs) has been associated with increased risk of various forms cancer and noncancerous diseases. Metabolic conversions iAs that yield highly toxic genotoxic methylarsonite (MAsIII) dimethylarsinite (DMAsIII) may play a significant role in determining the extent character cancer-promoting effects exposure. In this study we examined relationship between urinary profiles MAsIII DMAsIII skin lesion markers toxicity individuals exposed drinking water. The...
Abstract Background Human exposures to inorganic arsenic (iAs) have been linked an increased risk of diabetes mellitus. Recent laboratory studies showed that methylated trivalent metabolites iAs may play key roles in the diabetogenic effects iAs. Our study examined associations between chronic exposure drinking water, metabolism iAs, and prevalence arsenicosis-endemic areas Mexico. Methods We used fasting blood glucose (FBG), plasma insulin (FPI), oral tolerance test (OGTT), glycated...
The Biomarkers of Exposure to ARsenic (BEAR) pregnancy cohort in Gómez Palacio, Mexico was recently established better understand the impacts prenatal exposure inorganic arsenic (iAs). In this study, we examined a subset ( n = 40) newborn cord blood samples for microRNA (miRNA) expression changes associated with utero exposure. Levels iAs maternal drinking water (DW‐iAs) and urine were assessed. DW‐iAs ranged from below detectable values 236 µg/L (mean 51.7 µg/L). Total (U‐tAs) defined as...
Prenatal exposure to inorganic arsenic (iAs) is detrimental the health of newborns and increases risk disease development later in life. Here we examined a subset newborn cord blood leukocyte samples collected from subjects enrolled Biomarkers Exposure ARsenic (BEAR) pregnancy cohort Gómez Palacio, Mexico, who were exposed range drinking water concentrations (0.456–236 µg/l). Changes iAs-associated DNA 5-methylcytosine methylation assessed across 424 935 CpG sites representing 18 761 genes...
Inorganic arsenic (iAs) is an environmental toxicant currently poisoning millions of people worldwide, and chronically exposed individuals are susceptible to arsenicosis or poisoning. Using a state-of-the-art technique map the methylomes our study subjects, we identified large interactome hypermethylated genes that enriched for their involvement in arsenic-associated diseases, such as cancer, heart disease, diabetes. Notably, have uncovered arsenic-induced tumor suppressorome, complex 17...
Exposure to inorganic arsenic (iAs) from drinking water is a global public health problem, yet much remains unknown about the extent of exposure in susceptible populations.
Exposure to arsenic (As) concentrations in drinking water > 150 μg/L has been associated with risk of diabetes and cardiovascular disease, but little is known about the effects lower exposures.
ABSTRACT Biotransformation of inorganic arsenic (iAs) is one the factors that determines character and magnitude diverse detrimental health effects associated with chronic iAs exposure, but it unknown how biotransformation may impact epigenome. Here, we integrated analyses genome‐wide, gene‐specific promoter DNA methylation levels peripheral blood leukocytes urinary arsenical concentrations subjects from a region Mexico high in drinking water. These revealed dramatic differences profiles...
Inorganic arsenic (iAs) and fluoride (F−) are naturally occurring drinking water contaminants. However, co-exposure to these contaminants its effects on human health understudied. The goal of this study was examined exposures iAs F− in Chihuahua, Mexico, where exposure has been associated with adverse effects. All 1119 eligible Chihuahua residents (>18 years) provided a sample spot urine samples. concentrations samples ranged from 0.1 419.8 µg As/L 0.05 11.8 mg F−/L. Urinary (U-tAs)...
Large interindividual variability in urinary arsenic profiles, following chronic inorganic exposure, is well-known humans. To understand this variability, we studied the relationship between polymorphisms gene for human monomethylarsonic acid (MMAV) reductase/hGSTO1 and profiles of individuals chronically exposed to their drinking water. ensure that did not overlook rare polymorphisms, included public databases, amplified sequenced all six exons flanking regions, using DNA isolated from...
A growing number of studies link chronic exposure to inorganic arsenic (iAs) with the risk diabetes. Many these assessed iAs by measuring (As) species in urine. However, this approach has been criticized because uncertainties associated renal function and urine dilution diabetic individuals.