A5065931775- Carcinogens and Genotoxicity Assessment
- Pharmacogenetics and Drug Metabolism
- Heavy Metal Exposure and Toxicity
- Trace Elements in Health
- Arsenic contamination and mitigation
- Glutathione Transferases and Polymorphisms
- Heme Oxygenase-1 and Carbon Monoxide
- Drug Transport and Resistance Mechanisms
- Neonatal Health and Biochemistry
- Porphyrin Metabolism and Disorders
- Drug-Induced Hepatotoxicity and Protection
- Microbial bioremediation and biosurfactants
- Environmental Toxicology and Ecotoxicology
- Chemical Safety and Risk Management
- Effects and risks of endocrine disrupting chemicals
- Animal testing and alternatives
- Pharmacological Effects and Toxicity Studies
- Heavy metals in environment
- Immunotoxicology and immune responses
- Pesticide Exposure and Toxicity
- Eicosanoids and Hypertension Pharmacology
- Genomics, phytochemicals, and oxidative stress
- Analytical chemistry methods development
- Toxic Organic Pollutants Impact
- Enzyme-mediated dye degradation
Center for Research and Advanced Studies of the National Polytechnic Institute
2014-2025
Instituto Politécnico Nacional
2012-2025
Instituto de Estudios Avanzados
2005
Universidade de Vigo
2000-2001
Centro de Investigación en Materiales Avanzados
1997
Western University
1992-1995
Health Sciences Centre
1992
University of Surrey
1985-1992
Universidad Autónoma de Coahuila
1983-1988
British Council
1988
The conventional Tessier and BCR sequential extraction methods were applied to metal partitioning in sewage sludge samples collected from a waste water treatment plant. results obtained by for Cu, Cr, Ni, Pb Zn compared with those estimated single extractions using identical operating conditions each individual fraction. content the extracts was measured flame atomic absorption spectrometry. In all fractions of method, three first good agreement procedures. oxidizable fraction method should...
The ability of human cytochromes P450 other than CYP2E1 to catalyse the 6-hydroxylation chlorzoxazone (6-OH-CHZ) was examined in vitro using liver microsomal preparations and vivo as a metabolic probe. Chlorzoxazone activity significantly correlated with 4-nitrophenol 2-hydroxylase immunodetected 14 samples (r = 0.92 0.81, P < 0.001, respectively). Conversely, this catalytic not CYP 3A or CYP1A activities. Diethyldithiocarbamate (DEDTC), specific inhibitor, reduced 6-hydroxylase by 92.3 +/-...
Evaluation of contaminated sites is usually performed by chemical analysis pollutants in soil. This not enough either to evaluate the environmental risk soil nor efficiency cleanup techniques. Information on bioavailability complex mixtures xenobiotics and degradation products cannot be totally provided analytical data, but results from bioassays can integrate effects mixtures. In preservation human health environment quality, it important assess ecotoxicological soils obtain a better...
1 A detailed study of the urinary excretion pattern porphyrins in humans chronically exposed to As via drinking water was performed using high performance liquid chromatography (HPLC) 2 Thirty-six individuals (15 men and 21 women) were selected from a town which had 0.400 mg L -1 water. The control group consisted thirty-one (13 18 whose concentration 0.020 . 3 major abnormalities porphyrin observed arsenic-exposed were: (a) significant reductions coproporphyrin III resulting decreases COPRO...
Abstract The acute administration of sodium arsenite (AsIII) to rats resulted in a biphasic alteration the hepatic cytosolic “free” heme pool. first stage was an increase without significant effects on content cytochrome P ‐450 or bilirubin excretion. second consisted continuous fall and ‐450. These changes were concurrent with eight‐fold oxygenase activity associated marked elevations biliary excretion bilirubin. bile collected from chronically cannulated avoid artifacts related anesthesia...