A5066538184- Calpain Protease Function and Regulation
- Genetic Associations and Epidemiology
- Meat and Animal Product Quality
- Genetics and Neurodevelopmental Disorders
- Peroxisome Proliferator-Activated Receptors
- Pancreatic function and diabetes
- Metabolomics and Mass Spectrometry Studies
- Stress Responses and Cortisol
- Diet and metabolism studies
- Connexins and lens biology
- RNA modifications and cancer
- Genetic Mapping and Diversity in Plants and Animals
- Cancer-related gene regulation
- Diabetes and associated disorders
- RNA regulation and disease
- Wnt/β-catenin signaling in development and cancer
- Hormonal Regulation and Hypertension
- Birth, Development, and Health
- Tryptophan and brain disorders
- Adrenal Hormones and Disorders
- Lipid metabolism and biosynthesis
- Diet, Metabolism, and Disease
- Regulation of Appetite and Obesity
- Consumer Attitudes and Food Labeling
- Diabetes Treatment and Management
National Institute of Genomic Medicine
2014-2024
Instituto de Medicina Genómica
2016
University of Chicago
2000-2006
Howard Hughes Medical Institute
2001
Universidad Nacional Autónoma de México
1997
Mexico is developing the basis for genomic medicine to improve healthcare of its population. The extensive study genetic diversity and linkage disequilibrium structure different populations has made it possible develop tagging imputation strategies comprehensively analyze common variation in association studies complex diseases. We assessed benefit a Mexican haplotype map identification genes related diseases evaluated diversity, patterns, extent sharing using genomewide data from Mestizos...
Several studies have identified nearly 40 different type 2 diabetes susceptibility loci, mainly in European populations, but few of them been evaluated the Mexican population. The aim this study was to examine extent which 24 common genetic variants previously associated with are Mestizos. Twenty-four single nucleotide polymorphisms (SNPs) or near genes (KCNJ11, PPARG, TCF7L2, SLC30A8, HHEX, CDKN2A/2B, CDKAL1, IGF2BP2, ARHGEF11, JAZF1, CDC123/CAMK1D, FTO, TSPAN8/LGR5, KCNQ1, THADA, ADAMTS9,...
Major depressive disorder (MDD) increases the risk of type 2 diabetes (T2D) by 60% in untreated patients, and hypercortisolism is common MDD as well some patients with T2D. Patients MDD, despite hypercortisolism, show inappropriately normal levels corticotropin-releasing hormone (CRH) plasma adrenocorticotropin (ACTH) cerebrospinal fluid, which might implicate impaired negative feedback. Also, a positive feedback loop CRH–norepinephrine (NE)–CRH system may be involved Dysfunctional CRH...
Obesity is a major public health problem worldwide. The quantity and site of accumulation adipose tissue great importance for the physiopathology this disease.The aim study was to assess effect high carbohydrate diet on distribution.Male Wistar rats, control (CONT) sucrose (HSD; 30% in their drinking water), were monitored during 24 weeks total energy macronutrient intake estimated by measuring daily average consumption. A bioelectrical impedance procedure performed at 22 treatment body...
We investigated the patterns and extent of linkage disequilibrium (LD) in vicinity type 2 diabetes gene calapin-10 (CAPN10) Mexican Americans, European African Chinese Americans. found that CAPN10 occurs within a single block high LD decays rapidly outside gene. This reduces likelihood associations between polymorphisms could be attributed to variation at some distance from CAPN10. also consistently observed cases have more extensive than control subjects families with evidence for without...
Alterations in the activity of transcription factor 7-like 2 (TCF7L2) generate defects previously associated with neuropsychiatric disorders. We investigated role TCF7L2 gene major depressive disorder (MDD), type diabetes (T2D), and MDD-T2D comorbidity. tested whether is linkage to and/or disequilibrium (LD, namely association) MDD, T2D, MDD-T2D.In 212 families T2D MDD Italian population, we analyzed 80 microarray-based SNPs using Pseudomarker software for LD under recessive model complete...
Transcription factor 7-like 2 (TCF7L2) gene variants confer risk for type diabetes and metabolic traits. We investigated the role of TCF7L2-variants in polycystic ovarian syndrome (PCOS), which is a common endocrine disorder affecting women reproductive age. tested whether TCF7L2 are linkage to and/or disequilibrium [(LD), namely association)] with PCOS.Within 212 families from Italian peninsular population, we analyzed 78 using Pseudomarker software LD PCOS under dominant model complete...
Abstract Major depressive disorder (MDD) and type 2 diabetes (T2D) are complex disorders whose comorbidity can be due to hypercortisolism may explained by dysfunction of the corticotropin-releasing hormone receptor 1 (CRHR1) cortisol feedback within hypothalamic–pituitary–adrenal axis (HPA axis). To investigate role CRHR1 gene in familial T2D, MDD, MDD-T2D comorbidity, we tested 152 single-nucleotide-polymorphisms (SNPs), via 2-point parametric linkage disequilibrium (LD; i.e., association)...
Mutations in transcription factors that play a role the development of endocrine pancreas, such as insulin promoter factor-1 and NeuroD1/BETA2, have been associated with diabetes. Cell type–specific members basic helix-loop-helix (bHLH) family essential roles maintenance many differentiated cell types, including pancreatic β-cells. Neurogenin 3 is bHLH factor expressed developing central nervous system embryonic pancreas. Mice lacking this fail to develop any islet cells die postnatally from...
Dyslipidemia is a major public health problem, and therefore, it important to develop dietary strategies diminish the prevalence of this disorder. It was recently reported that diet may play an role in triggering insulin resistance by interacting with genetic variants at CAPN10 gene locus patients metabolic syndrome. Nonetheless, remains unknown whether genes involved development type 2 diabetes are associated variations high-density lipoprotein cholesterol (HDL-C). The study used...
Rigorous nutritional care during early life leads to healthy adulthood. Cardiovascular and metabolic disorders, the most prevalent clinical challenges worldwide, are epidemiologically linked poor habits throughout life. We aimed understand whether postnatal overnutrition (PO) initiated lactation affects markers vascular function later in To test this hypothetical effect, we studied a PO Wistar rat model based on adjusting litter size at third day of age three pups eight for control group...