A5000130577- COVID-19 Clinical Research Studies
- SARS-CoV-2 and COVID-19 Research
- Long-Term Effects of COVID-19
- Gout, Hyperuricemia, Uric Acid
- Proteoglycans and glycosaminoglycans research
- Gut microbiota and health
- Sepsis Diagnosis and Treatment
- Osteoarthritis Treatment and Mechanisms
- Adipokines, Inflammation, and Metabolic Diseases
- Respiratory Support and Mechanisms
- Protease and Inhibitor Mechanisms
- Metabolism and Genetic Disorders
- Pleural and Pulmonary Diseases
- Phagocytosis and Immune Regulation
- Hip disorders and treatments
- Alcohol Consumption and Health Effects
- Nutrition and Health in Aging
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Essential Oils and Antimicrobial Activity
- Silk-based biomaterials and applications
- Adipose Tissue and Metabolism
- Immune Cell Function and Interaction
- Healthcare and Venom Research
- Metabolomics and Mass Spectrometry Studies
- Bee Products Chemical Analysis
Instituto Nacional de Rehabilitación
2022-2025
Secretaria de Salud
2024
Universidad Autónoma Metropolitana
2020-2023
Mexican Social Security Institute
2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the current disease 2019 (COVID-19) pandemic, affecting more than 219 countries and causing death of 5 million people worldwide. The genetic background represents a factor that predisposes way host responds to SARS-CoV-2 infection. In this sense, variants ACE ACE2 could explain observed interindividual variability COVID-19 outcomes. order improve understanding how are involved in severity COVID-19, we included...
Introduction Severe acute respiratory syndrome–coronavirus 2 (SARS-CoV-2) infection triggers inflammatory clinical stages that affect the outcome of patients with coronavirus disease 2019 (COVID-19). Disease severity may be associated a metabolic imbalance related to amino acids, lipids, and energy-generating pathways. The aim this study was characterize profile acids acylcarnitines in COVID-19 patients. A multicenter, cross-sectional carried out. total 453 individuals were classified by...
Abstract Cytokines and chemokines are essential for establishing an appropriate immune response to severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Variations in the genes encoding cytokines strongly influence pathogenic challenges disease outcomes. This study was carried out determine associations of polymorphisms TNF -α , IL-6 IL-8, IL-10 CCL5 with COVID-19 severity. A total 627 unvaccinated patients were classified according WHO We evaluated levels IFN-α, IFN-γ, TNF-α, IL-1R,...
Several pathologies with metabolic origin, such as hyperuricemia and gout, have been associated the gut microbiota taxonomic profile. However, there is no evidence of which bacterial genes are being expressed in microbiome, their potential effects on gout. We sequenced RNA 26 fecal samples from 10 healthy normouricemic controls, asymptomatic (AH), six gout patients. The coding sequences were mapped to KEGG orthologues (KO). compared expression levels using generalized linear models validated...
TNF and IFN-γ are key proinflammatory cytokines implicated in the pathophysiology of COVID-19. Toll-like receptor (TLR)7 TLR8 known to recognize SARS-CoV-2 induce production. However, it is unclear whether levels altered through TLR-dependent pathways these mediate disease severity during This study aimed investigate association between TNF/IFN-γ immune cell activation understand their role better. We enrolled 150 COVID-19 patients, who were classified by systemic (high (H) or normal–low...
During a viral infection, the immune response is mediated by toll-like receptors and myeloid differentiation Factor 88 (MyD88) that play an important role sensing infections such as SARS-CoV-2 which has claimed lives of more than 6.8 million people around world. We carried out cross-sectional with population 618 SARS-CoV-2-positive unvaccinated subjects further classified based on severity: 22% were mild, 34% severe, 26% critical, 18% deceased. Toll Like Receptor 7 (TLR7) single-nucleotide...
Serine proteases play a critical role during SARS-CoV-2 infection. Therefore, polymorphisms of transmembrane protease serine 2 (TMPRSS2) and serpine family E member 1 (SERPINE1) could help to elucidate the contribution variability COVID-19 outcomes. To evaluate genetic variants genes previously associated with outcomes, we performed cross-sectional study in which 1536 SARS-CoV-2-positive participants were enrolled. TMPRSS2 (rs2070788, rs75603675, rs12329760) SERPINE1 (rs2227631, rs2227667,...
The preservation of the chondrogenic phenotype and hypoxia-related physiological microenvironment are major challenges in 2D culture primary human chondrocytes. To address this problem, we develop a 3D system generating scaffold-free spheroids from Our results highlight potential cultured articular chondrocytes combined with hypoxia independently cartilage source. After 14 days culture, developed homogenous diameter shape hyaline donors. Spheroids generated showed significantly increased...
<h3>Background:</h3> The importance of the gut microbiota in several rheumatic and metabolic pathologies, including hyperuricemia gout, has been demonstrated by a large body scientific evidence. However, there are no studies on specific bacterial genes expressed microbiome that might have functional role gout. <h3>Objectives:</h3> objective this study was to analyze meta-transcriptome gout patients normouricemic controls. <h3>Methods:</h3> 26 stool samples from 10 healthy subjects,...
<title>Abstract</title> Background Several pathologies with metabolic origin, such as hyperuricemia and gout, have been associated the gut microbiota taxonomic profile. However, there is no evidence of which bacterial genes are being expressed in microbiome, their potential effects on gout. Materials Methods We sequenced RNA 26 fecal samples from 10 healthy normouricemic controls, asymptomatic (AH), six gout patients. The coding sequences were mapped to KEGG orthologues (KO). compared...
Malignant ascites (MA) and malignant pleural effusion (MPE) are frequently developed in patients with metastatic cancer; however, the biological properties of these fluids have not been clarified. The present study explored role a low molecular fraction derived from effusions on activation peripheral blood mononuclear cells proliferation breast cancer fibroblast 55x cells. A <10‑kDa 41 oncological 34 individuals without was purified, its potential inhibiting nitric oxide (NO) production...
Introduction:The Coronavirus Disease (COVID-19) has been a public health problem worldwide for considerable time.According to the COVID-19 dashboard at Johns Hopkins University (JHU), Mexico is in fourteenth place of reported cases.Some studies have described some risk factors associated with having COVID-19.However, develop different outcomes unclear.Objective: To describe outcomes.Material and methods: We carried out multicenter cross-sectional study, from June 2020 March2021.A...