A5075103191- Genetic Associations and Epidemiology
- Regulation of Appetite and Obesity
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Pancreatic function and diabetes
- Neurotransmitter Receptor Influence on Behavior
- Neuroscience and Neuropharmacology Research
- Cardiovascular Health and Disease Prevention
- Sleep and Wakefulness Research
- Peroxisome Proliferator-Activated Receptors
- Diet and metabolism studies
- Metabolism, Diabetes, and Cancer
- Receptor Mechanisms and Signaling
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Lipid metabolism and disorders
- RNA modifications and cancer
- Neuroendocrine regulation and behavior
- Adipokines, Inflammation, and Metabolic Diseases
- Lipoproteins and Cardiovascular Health
- Pharmacology and Obesity Treatment
- Cholesterol and Lipid Metabolism
- Cardiovascular Function and Risk Factors
- Cardiovascular Disease and Adiposity
- Hypothalamic control of reproductive hormones
- Diabetes Treatment and Management
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2016-2025
Universidad Del Valle De Cuernavaca
2025
Tecnológico de Monterrey
2018-2021
Consejo Nacional de Humanidades, Ciencias y Tecnologías
2018
University of Eastern Finland
2016
Kuopio University Hospital
2016
Universidad Autónoma Metropolitana
2016
Universidad de Los Andes
2007
University of the Andes
1971-2006
Merck (Japan)
1999
We developed a novel non-insulin-based fasting score to evaluate insulin sensitivity validated against the euglycemic-hyperinsulinemic clamp (EHC). also evaluated its correlation with ectopic fact accumulation and capacity predict incident type 2 diabetes mellitus (T2D).The discovery sample was composed by 125 subjects (57 without 68 T2D) that underwent an EHC. defined METS-IR as Ln((2*G0)+TG0)*BMI)/(Ln(HDL-c)) (G0: glucose, TG0: triglycerides, BMI: body mass index, HDL-c: high-density...
<h3>Background</h3> The Mexican population and others with Amerindian heritage exhibit a substantial predisposition to dyslipidemias coronary heart disease. Yet, these populations remain underinvestigated by genomic studies, date, no genome-wide association (GWA) studies have been reported for lipids in rapidly expanding populations. <h3>Methods findings</h3> We performed two-stage GWA study hypertriglyceridemia low high-density lipoprotein cholesterol (HDL-C) Mexicans (n=4361), identified...
Polygenic severe obesity (body mass index [BMI] ≥40 kg/m2) has increased, especially in Hispanic/Latino populations, yet we know little about the underlying mechanistic pathways. We analyzed whole-blood multiomics data to identify genes differentially regulated Mexican Americans from Cameron County Hispanic Cohort. Our RNA sequencing analysis identified 124 significantly expressed between cases (BMI and controls <25 kg/m2); 33% replicated an independent sample same population. integrative...
Dyslipidemia and obesity are especially prevalent in populations with Amerindian backgrounds, such as Mexican–Americans, which predispose these to cardiovascular disease. Here we design an approach, known the cross-population allele screen (CPAS), conduct prior a genome-wide association study (GWAS) 19,273 Europeans Mexicans, order identify risk genes Mexicans. Utilizing CPAS restrict GWAS input variants only those differing frequency between two populations, novel lipid genes,...
Type 2 diabetes (T2D) affects more than 415 million people worldwide, and its costs to the health care system continue rise. To identify common or rare genetic variation with potential therapeutic implications for T2D, we analyzed replicated genome-wide protein coding in a total of 8,227 individuals T2D 12,966 without Latino descent. We identified novel variant IGF2 gene associated ∼20% reduced risk T2D. This variant, which has an allele frequency 17% Mexican population but is Europe,...
Hypertension is associated with insulin resistance (IR), metabolic syndrome (MS), and arterial stiffness. Non-insulin-based IR indexes were developed as tools for screening. Here, we aimed to evaluate the novel non-insulin-based Metabolic Score (METS-IR) index prediction of incident hypertension stiffness evaluated using pulse wave velocity (PWV) analysis, compared other indexes. We two populations, a cross-sectional evaluation high-risk individuals (n = 305) wide range comorbidities...
Type 2 diabetes mellitus (T2D) is a leading cause of morbidity and mortality in Mexico. Here, we aimed to report incidence rates (IR) type middle-aged apparently-healthy Mexican adults, identify risk factors associated ID develop predictive model for high-risk population.Prospective 3-year observational cohort, comprised adults from urban settings central Mexico whom demographic, anthropometric biochemical data was collected. We evaluated using Cox proportional hazard regression developed...
Reverse causality has made it difficult to establish the causal directions between obesity and prediabetes insulin resistance. To disentangle whether causally drives resistance already in non-diabetic individuals, we utilized UK Biobank METSIM cohort perform a Mendelian randomization (MR) analyses individuals. Our results suggest that both systemic are caused by (p = 1.2×10−3 p 3.1×10−24). As reflects amount of body fat, next studied how adipose tissue affects We performed bulk...
Obesity predisposes individuals to multiple cardiometabolic disorders, including type 2 diabetes (T2D). As body mass index (BMI) cannot reliably differentiate fat from lean mass, the metabolically detrimental abdominal obesity has been estimated using waist-hip ratio (WHR). Waist-hip adjusted for (WHRadjBMI) in turn is a well-established sex-specific marker and adiposity, predictor of adverse metabolic outcomes, such as T2D. However, underlying genes regulatory mechanisms orchestrating sex...
Genome-wide association studies (GWAS) have identified 58 susceptibility alleles across 37 regions associated with the risk of colorectal cancer (CRC) P < 5×10−8. Most been conducted in non-Hispanic whites and East Asians; however, generalizability these findings potential for ethnic-specific variation Hispanic Latino (HL) individuals largely understudied. We describe first GWAS common genetic contributing to CRC HL (1611 cases 4330 controls). also examine known implement imputation-based...
Approximately 20% of the global population has a Lp(a) concentrations above 50 mg/dL (> 125nmol/L), yet many remain unaware associated cardiovascular risks. In Mexico, routine measurement is uncommon. This study aimed to investigate frequency testing, and clinical actions taken by physicians upon detecting elevated in patients at tertiary medical institution. Using an algorithm-based screening system, we reviewed biochemical data with measurements from 2019 2024. Data were retrieved...
Metabolic syndrome contributes to the development of albuminuria and decrease glomerular filtration rate (GFR) in type 2 diabetes patients. The aim this study was analyze effect MS treatment on progression diabetic nephropathy (DN).This a retrospective comparative cohort study. Baseline follow-up data related presence metabolic syndrome, microalbuminuria (mA), GFR were obtained individuals with diabetes. Subjects classified two groups: (1) With correction (2) without at follow-up....
Objective A haplotype at chromosome 17p13 that reduces expression and function of the solute carrier transporter SLC16A11 is associated with increased risk for type 2 diabetes in Mexicans. We aim to investigate detailed metabolic profile carriers identify potential physiological mechanisms explaining risk. Design Cross-sectional study. Methods evaluated ( n = 72) non-carriers 75) haplotype, or without diabetes. An independent sample 1069 subjects was used replicate biochemical findings. The...
OBJECTIVE To assess whether an ethnic-specific variant (p.E508K) in the maturity-onset diabetes of young (MODY) gene hepatocyte nuclear factor-1α (HNF1A) found Mexicans is associated with higher sensitivity to sulfonylureas, as documented patients MODY3. RESEARCH DESIGN AND METHODS We recruited 96 participants (46 carriers and 50 age- sex-matched noncarriers). Response glipizide (one 2.5–5.0-mg dose), metformin (four 500-mg doses), oral glucose challenge was evaluated using a previously...
The efficacy of the antiviral agent Amantadine (AM, 5-100 mg/kg/sc, ip or intrahypothalamically, 12.5 - 100 μg bilaterally) in influencing body weight and food intake drug-free rats, preventing neuroleptic-induced gain, was assessed adult female rats. In acute administration systemic AM directly injected lateral hypothalamus (LH) displayed a significant dose-dependent anorectic effect (p < 0.001). This could be mediated by brain monoaminergic system, because local injections increased...