A5084409231- Birth, Development, and Health
- Adipose Tissue and Metabolism
- Gestational Diabetes Research and Management
- Diet and metabolism studies
- Obesity, Physical Activity, Diet
- Pregnancy and preeclampsia studies
- Fatty Acid Research and Health
- Stress Responses and Cortisol
- Adipokines, Inflammation, and Metabolic Diseases
- Ovarian function and disorders
- Regulation of Appetite and Obesity
- Neuroendocrine regulation and behavior
- Reproductive Biology and Fertility
- Sperm and Testicular Function
- Diet, Metabolism, and Disease
- Hormonal Regulation and Hypertension
- Hypothalamic control of reproductive hormones
- Infant Nutrition and Health
- Growth Hormone and Insulin-like Growth Factors
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- Effects and risks of endocrine disrupting chemicals
- Tryptophan and brain disorders
- Apelin-related biomedical research
- Epigenetics and DNA Methylation
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán
2016-2025
Universidad Nacional Autónoma de México
2023-2025
Consejo Nacional de Humanidades, Ciencias y Tecnologías
2022
PhysioPathologie des Adaptations Nutritionnelles
2018-2019
Zero to Three
2017
Information Group on Reproductive Choice
2017
Universidad Juárez Autónoma de Tabasco
2007
Instituto Politécnico Nacional
2007
Secretaria de Salud
2007
Instituto Nacional de Perinatología
2007
Extensive epidemiological and experimental evidence indicates that a sub-optimal environment during fetal neonatal development in both humans animals may programme offspring susceptibility to later of chronic diseases including obesity diabetes are the result altered carbohydrate metabolism. We determined effects protein restriction pregnancy and/or lactation on growth, serum leptin, glucose insulin responses tolerance test male female at 110 days postnatal life. fed Wistar rats normal...
Compelling epidemiological and experimental evidence indicates that a suboptimal environment during fetal neonatal development in both humans animals may programme offspring susceptibility to later of several chronic diseases including obesity diabetes which altered carbohydrate metabolism plays central role. One the most interesting significant features developmental programming is from studies adverse consequences intrauterine environments can be passed transgenerationally mother (F0)...
Nutrient restriction during pregnancy and lactation impairs growth development. Recent studies demonstrate long‐term programming of function specific organ systems resulting from suboptimal environments fetal life development up to weaning. We determined effects maternal protein (50% control intake) and/or in rats on the reproductive system male progeny. Rats were fed either a 20% casein diet (C) or restricted (R) 10% pregnancy. After delivery mothers received C R until weaning provide four...
Recent studies demonstrate long-term programming of function specific organ systems resulting from suboptimal environments during fetal life and development up to weaning. Nutrient restriction pregnancy lactation impairs overall growth development. We determined the effects maternal protein (MPR; 50% normal intake) and/or in rats on ageing reproductive system female progeny. Rats were fed either a control 20% casein diet (C) or restricted (R) 10% pregnancy. After delivery mothers received C...
Protein restriction in pregnancy produces maternal and offspring metabolic dysfunction potentially as a result of oxidative stress. Data are lacking on the effects inhibition We hypothesized that resveratrol administration decreases stress, preventing, at least partially, low protein-induced dysfunction. In present study, pregnant wistar rats ate control (C) (20% casein) or protein-restricted (R) (10% isocaloric diet. Half each group received orally, 20 mg kg(-1) day(-1), throughout...
Key points Maternal high‐fat diet consumption predisposes to metabolic dysfunction in male and female offspring at young adulthood. obesity programs non‐alcoholic fatty liver disease (NAFLD) a sex‐dependent manner. We demonstrate transcriptome profiles rat of obese mothers. In this study, we focused on pathways related insulin, glucose lipid signalling. These results improve understanding the mechanisms by which maternal affects offspring. Abstract (MO) (F1) obesity, insulin resistance (IR)...
Obesity involving women of reproductive years is increasing dramatically in both developing and developed nations. Maternal obesity accompanying high energy obesogenic dietary (MO) intake prior to throughout pregnancy lactation program offspring physiological systems predisposing altered carbohydrate lipid metabolism. Whether maternal obesity-induced programming outcomes are reversible by commencing before conception remains an unanswered question clinical importance. We induced...
Suboptimal developmental environments program offspring to lifelong metabolic problems. The aim of this study was determine the impact protein restriction in pregnancy on maternal liver lipid metabolism at 19 days gestation (dG) and its effect fetal brain development. Control (C) restricted (R) mothers were fed with isocaloric diets containing 20 10% casein. At dG, blood livers brains collected. Serum insulin leptin levels determinate mothers. Maternal quantification performed. fatty acids...
Abstract We studied the effects of maternal high fat diet (HFD, 25% calories from administered before and during pregnancy lactation) dietary intervention (switching dams HFD to control diet) at different periconceptional periods on male offspring anxiety related behavior, exploration, learning, motivation. From weaning postnatal day (PND) 21, female subjects produced be mothers in study received either (CTR – 5% fat), through lactation (MO), PNDs 21–90 followed by CTR (pre‐gestation (PG)...
Abstract Maternal protein deficiencies can developmentally program offspring to lifelong dysfunction of many physiological systems. We hypothesized that maternal isocaloric low diet during fetal and early postnatal development would negatively affect female anxiety, exploration, associative learning motivation as measured by the elevated plus maze (EPM), open field test (OFT), operant conditioning progressive ratio task, respectively. Control mothers (C) received a 20% casein restricted (R)...
Maternal obesity programmes offspring development. We addressed maternal effects induced by high-fat diets on mammary gland (MG) structure and function brain, liver fat outcomes. Mothers were fed control (C, n 5) or obesogenic (MO, diet from the time they weaned through pregnancy beginning at 120 d, lactation. At postnatal day (PND) 20, milk leptin nutrients determined. end of lactation, MG fatty acid profile measured. Desaturase (Δ6D Δ5D) elongase (ELOVL 5 ELOVL 2) protein was measured...
Abstract This study evaluated if there is a sexual dimorphism in the acute kidney injury (AKI) to chronic disease (CKD) transition and time-course of potential mechanisms involved dimorphic response. Female male rats were divided into sham-operated or underwent 45-min renal ischemia (F + IR, M IR). All groups studied at 24-h 1, 2, 3, 4-months post-ischemia. Additionally, oophorectomized sham IR groups. After 24-h, AKI extent was simllar females males, but female exhibited less oxidative...
Metabolic syndrome (MS) is a cluster of signs that increases the risk to develop diabetes mellitus type 2 and cardiovascular disease. In last years, growing interest study relationship between MS psychiatric disorders, such as depression anxiety, has emerged obtaining conflicting results. Diet-induced rat models have only examined effects high-fat or mixed cafeteria diets limited extent. We explored whether an anxiety-like behavior was associated with in non-stressed rats chronically...
Unique situations in female physiology require volume retention. Accordingly, a dimorphic regulation of the thiazide-sensitive Na(+)-Cl(-) cotransporter (NCC) has been reported, with higher activity females than males. However, little is known about hormones and mechanisms involved. Here, we present evidence that estrogens, progesterone, prolactin stimulate NCC expression phosphorylation. The sex difference abundance, however, species dependent. In rats, phosphorylation males, while mice...
Maternal overnutrition including pre-pregnancy, pregnancy and lactation promotes a lipotoxic insult leading to metabolic dysfunction in offspring. Diet-induced obesity models (DIO) show that changes hypothalamic mitochondria fusion fission dynamics modulate dysfunction. Using three selective diet formula High fat (HFD), Cafeteria (CAF) Sugar Diet (HSD), we hypothesized maternal diets exposure program leads male offspring which is exacerbated by second after weaning. We exposed female Wistar...
Maternal hypercaloric exposure during pregnancy and lactation is a risk factor for developing diseases associated with inflammation such as obesity, diabetes and, neurological in the offspring. Neuroinflammation might modulate neuronal activation flavonoids are dietary compounds that have been proven to exert anti-inflammatory properties. Thus, aim of present study evaluate effect maternal supplementation (kaempferol-3-O-glucoside narirutin) on prevention depression-like behaviour female...