A5087223842- Birth, Development, and Health
- Epigenetics and DNA Methylation
- Fungal and yeast genetics research
- Diet and metabolism studies
- Pregnancy and preeclampsia studies
- Diet, Metabolism, and Disease
- Adipose Tissue and Metabolism
- Fermentation and Sensory Analysis
- Plant Gene Expression Analysis
- MicroRNA in disease regulation
- Digestive system and related health
- Health, Environment, Cognitive Aging
- Effects and risks of endocrine disrupting chemicals
- Autophagy in Disease and Therapy
- Gut microbiota and health
- RNA and protein synthesis mechanisms
- Muscle metabolism and nutrition
- Dietary Effects on Health
- Liver Disease Diagnosis and Treatment
- Plant and Fungal Interactions Research
- Selenium in Biological Systems
- RNA Research and Splicing
- Hormonal and reproductive studies
- Pancreatic function and diabetes
- Endoplasmic Reticulum Stress and Disease
Universidade Estadual Paulista (Unesp)
2020-2025
Background/Objectives: Translation and the formation of membraneless organelles are linked mechanisms to promote cell stress surveillance. LncRNAs responsive ethanol transcr_9136 SEY6210 strain transcr_10027 BY4742 appear act on tolerance in these strains. Here, we investigate whether responsiveness their role associated with protein biogenesis organelle assembly. Methods: transcr_9136∆ transcr_10027∆ wild-type counterparts were subjected maximum ethanol-tolerant stress. The expression...
Abstract This study aimed to investigate the mechanisms by which association between maternal hyperglycemia and postnatal high-fat diet (HFD) exposure compromises metabolic parameters hepatic autophagy in adult female pups. For this, Sprague Dawley rats, pups from nondiabetic (control = FC) or diabetic (FD) mothers, were fed a standard (SD) HFD weaning until adulthood ( n minimum 5 rats/group): FC/SD, FC/HFD, FD/SD, FD/HFD. In adulthood, these rats tested with oral glucose tolerance test,...
Ethanol (EtOH) alters many cellular processes in yeast. An integrated view of different EtOH-tolerant phenotypes and their long noncoding RNAs (lncRNAs) is not yet available. Here, large-scale data integration showed the core EtOH-responsive pathways, lncRNAs, triggers higher (HT) lower (LT) phenotypes. LncRNAs act a strain-specific manner EtOH stress response. Network omics analyses revealed that cells prepare for relief by favoring activation life-essential systems. Therefore, longevity,...
Obesity is a growing global epidemic associated with changes in the gut microenvironment and metabolic endotoxemia, which can exacerbate inflammatory processes. Citral (CT), monoterpene present essential oils, has been investigated for its anti-inflammatory, antioxidant, immunomodulatory properties. However, role modulating axis during alterations obesity remains unknown. In this study, we effects of CT on intestinal impairment induced by lipopolysaccharide (LPS) high-fat diet (HFD) vitro...
ABSTRACT Phthalates are a group of chemicals used as plasticizers to enhance the malleability and flexibility various products. The adrenal glands responsible for producing hormones that maintain homeostasis, regulate blood pressure, mediate stress responses. Early exposure environmental toxicants can impair important responses, which result in damage development functionality. This study aimed investigate effects maternal phthalate mixture on offspring's glands. Pregnant females (SD) were...
The developmental origins of health and disease concept links adult diseases with early-life exposure to inappropriate environmental conditions. Intrauterine postnatal malnutrition may lead an increased incidence type 2 diabetes, obesity, cardiovascular diseases. Maternal (MM) has also been associated prostate carcinogenesis. However, the molecular mechanisms this condition remain poorly understood. Using a proteomic analysis, we demonstrated that MM changed levels proteins growth factors,...
Abstract The Developmental Origins of Health and Disease (DOHaD) concept has provided the framework to assess how early life experiences can shape health disease throughout course. While maternal malnutrition been proposed as a risk factor for developmental programming prostate cancer (PCa), molecular mechanisms remain poorly understood. Using RNA-seq data, we demonstrated deregulation miR-206-Plasminogen (PLG) network in ventral (VP) young maternally malnourished offspring. RT-qPCR...
The Developmental Origins of Health and Disease (DOHaD) concept correlates early life exposure to stressor conditions with the increased incidence non-communicable chronic diseases, including prostate cancer (PCa), throughout span. However, molecular mechanisms involved in this process remain poorly understood. In study, deregulation two miRNAs (rno-miR-18a-5p rno-miR-345-3p) was described ventral VP old rats born dams fed a low protein diet (LPD) (6% diet) during gestational lactational...
Elevated ethanol concentrations in yeast affect the plasma membrane. The membrane has many lipid-protein complexes, such as Pma1 (MCP), Can1 (MCC), and eisosome complex. We investigated response of eisosomes, MCPs, membraneless structures to stress. found a correlation between stress proton flux with quick acidification medium. Moreover, influences symporter expression stressed cells. also suggest that acute from leads increases size SG number: we hypothesized eisosomes may protect APC...
The Developmental Origins of Health and Disease (DOHaD) concept explores the link between exposure to adverse conditions during fetal early childhood development onset chronic non-communicable diseases, such as prostate cancer (PCa). Changes in epigenetics that control gene expression have been identified potential contributors developmental origin PCa. Piwi-interacting RNAs (piRNAs), for example, transposable elements (TEs) maintain genome integrity germ cells. However, stress-induced...
Abstract Ethanol (EtOH) is a substantial stressor for Saccharomyces cerevisiae . Data integration from strains with different phenotypes, including EtOH stress-responsive lncRNAs, are still not available. We covered these issues seeking systems modifications that drive the divergences between higher (HT) and lower (LT) tolerant under their highest stress conditions. showed phenotypes neither related to high viability nor faster population rebound after relief. LncRNAs work on many in...
Abstract The Developmental Origins of Health and Disease (DOHaD) has provided the framework to assess how early life experiences can shape health disease throughout course. While maternal malnutrition been proposed as a risk factor for developmental programming prostate cancer (PCa), molecular mechanisms remain poorly understood. Here, we found an association between deregulation steroidogenesis impairment ventral (VP) growth in young offspring rats exposed low protein diet (LPD) during...