A5048649116- Testicular diseases and treatments
- Sperm and Testicular Function
- Cystic Fibrosis Research Advances
- Neonatal Respiratory Health Research
- Cancer-related molecular mechanisms research
- Sexual Differentiation and Disorders
- Neuroendocrine regulation and behavior
- Circadian rhythm and melatonin
- Hormonal and reproductive studies
- Reproductive Biology and Fertility
- Pregnancy-related medical research
- Neuroscience of respiration and sleep
- Tracheal and airway disorders
- MicroRNA in disease regulation
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Birth, Development, and Health
- Nutrition, Genetics, and Disease
- Circular RNAs in diseases
- Urologic and reproductive health conditions
- Rabbits: Nutrition, Reproduction, Health
- Chromatin Remodeling and Cancer
- Blood disorders and treatments
- Infant Nutrition and Health
- Renal and related cancers
- FOXO transcription factor regulation
Instituto Nacional de Pediatria
2015-2024
Secretaria de Salud
2016
Radioresistance of tumor cells gives rise to local recurrence and disease progression in many patients. MicroRNAs (miRNAs) are master regulators gene expression that control oncogenic pathways modulate the radiotherapy response cells. In present study, differential profiling assays identified 16 deregulated miRNAs acquired radioresistant breast cancer cells, which miR-122 was observed be up-regulated. Functional analysis revealed has a role as suppressor parental by decreasing survival...
To evaluate the associations between six single-nucleotide polymorphisms (SNPs) in intron 1 of FTO and body mass index (BMI), a case-control association study 2314 unrelated Mexican-Mestizo adult subjects was performed. The each SNP BMI tested using logistic linear regression adjusted for age, gender, ancestry assuming additive, recessive, dominant effects minor allele. Association analysis after stratification showed that all five SNPs (rs1121980, rs17817449, rs3751812, rs9930506,...
It is thought that the degeneration of germ cells associated with an increase in temperature due to cryptorchidism involves oxidative stress. α-Tocopherol a powerful antioxidant prevents oxidation polyunsaturated fats found membranes and stabilizes peroxyl radicals. For this reason we were interested determining role using experimental cryptorchidism, followed by orchidopexia neonatal rats. Eighty-four, 10-day-postpartum (dpp) male rats (Wistar strain) used divided into 7 groups: healthy...
Lead (Pb) exposure alters the temporal organization of several physiological and behavioural processes in which suprachiasmatic nucleus (SCN) hypothalamus plays a fundamental role. In this study, we evaluated effects chronic early Pb (CePbe) on morphology, cellular density relative optical (OD) cells SCN male rats. Female Wistar rats were exposed during gestation lactation to solution containing 320 ppm acetate through drinking water. After weaning, pups maintained with same water until...
Summary Neonatal exposure to monosodium glutamate ( MSG ) induces circadian disorders in several physiological and behavioural processes regulated by the suprachiasmatic nucleus SCN ). The objective of this study was evaluate effects neonatal on locomotor activity, morphology, cellular density expression proteins, as evaluated optical OD ), vasopressin VP )‐, vasoactive intestinal polypeptide VIP )‐ glial fibrillary acidic protein GFAP )‐immunoreactive cells . Male Wistar rats were used:...
Cryptorchidism (CO) is a risk factor for the development of testicular germ-cell tumors (TGCT). This supported by reports showing persistence gonocytes in CO patients. These cells are proposed to be related neoplasia situ (GCNIS), which considered precursor stage/lesion TGCT. Therefore, it that some patients with could express molecular markers In this study, we analyzed tissue samples from CO, TGCT, and controls. We determined expression POU5F1, PLAP, KIT immunohistochemistry...
Allelic variants in genes implicated the development of testicular germ cell tumor (TGCT) could be present patients with cryptorchidism (CO). Currently; mechanisms explaining this relationship are still unknown. In study common clinical features CO and TGCT 6 KIT AR associated to were analyzed. Population analyzed included 328 individuals: 91 CO; 79 TGCT, 13 them previous diagnosis, 158 healthy males. Of history CO, one patient (7.7%) presented heterozygous form variant rs121913507 two...
Serotonin (5-HT) is member of a family indolamine molecules that participate in wide variety biological processes. Despite its important role the regulation local blood systems, little known about physiological function 5-HT reproductive organs, functional implications, and reproduction mammals. In present work, we evaluated localization distribution (using histochemical analysis indolamines) different components serotoninergic system rat testes. We detected synthesis degradation through...
Cryptorchidism is a frequent genitourinary malformation considered as an important risk factor for infertility and testicular malignancy. The aetiology of cryptorchidism multifactorial in which certain SNPs, capable inhibiting the development gubernaculum, are implicated. We analysed 16 SNPs by allelic discrimination automated sequencing 85 patients 99 healthy people, with objective to identify association between these variants isolated cryptorchidism. In two different unilateral...
Studies in laboratory animals have shown that male offspring from dams, exposed to nicotine during pregnancy and postnatal periods, show alterations fertility, although the origin of this is still uncertain. In study, we examined a mouse model if process gonocyte maturation spermatogonia was affected dams with administration periods. BALB/C mice, without administrations were studied. The euthanized at 3, 7, 10, 16, 35 days postpartum (dpp). Testicular tissue samples processed for...
Cryptorchidism is the most common genitourinary birth defect in live newborn males and considered as an important risk factor for testicular germ cell tumors infertility. The Androgen Receptor gene this pathology due to its participation, mainly, inguinoscrotal phase of descent. We determine length CAG tract (AR) Mexican patients with nonsyndromic cryptorchidism.One hundred 15 were included; these, 62 had cryptorchidism 53 healthy volunteers. DNA was extracted from a peripheral blood...
Abstract Breast cancer cells exposed to radiotherapy frequently develop radiation resistance through molecular and phenotypic changes. While there is evidences of pathways controlling radioresistance, the evolution diverse cell phenotypes transcriptional changes as mediators radioresistance in breast are restricted. Moreover, effectiveness chemotherapy on radioresistant remains uncertain. In this work, an isogenic model (RR cells) used study phenotype. RR show high survival rates after...
Summary Pyrimethamine ( PYR ) is a drug used in the treatment of newborn with congenital Toxoplasmosis. Even when highly specific against parasites, it may provoke neutropenia patients apart from other affectations, conditions that usually justify its suspension. Moreover, medication toxoplasmosis coincides proliferation stage Sertoli and germ cells. Although, there are several reports on effect this mature testes, records effects testes young individuals yet process growth still lacking....