A5033119493- Neuroinflammation and Neurodegeneration Mechanisms
- MicroRNA in disease regulation
- Neuroscience and Neuropharmacology Research
- Circular RNAs in diseases
- Nerve injury and regeneration
- Cancer-related molecular mechanisms research
- Antibiotic Resistance in Bacteria
- Trace Elements in Health
- RNA Interference and Gene Delivery
- Neonatal and fetal brain pathology
- Neurogenesis and neuroplasticity mechanisms
- Neuropeptides and Animal Physiology
- Cannabis and Cannabinoid Research
- Pregnancy and preeclampsia studies
- Neurological Disease Mechanisms and Treatments
- Virus-based gene therapy research
- Neurobiology and Insect Physiology Research
- Neurotransmitter Receptor Influence on Behavior
- Biochemical effects in animals
- Prenatal Substance Exposure Effects
- Alzheimer's disease research and treatments
- Nitric Oxide and Endothelin Effects
- Cerebral Palsy and Movement Disorders
- Sleep and Wakefulness Research
- Autism Spectrum Disorder Research
Institute for Social Security and Services for State Workers
2015-2024
Instituto Politécnico Nacional
2015-2024
Center for Research and Advanced Studies of the National Polytechnic Institute
2002-2006
Abstract Deregulated expression of microRNAs has been associated with angiogenesis. Studying the miRNome locally advanced breast tumors we unsuspectedly found a dramatically repression miR-204, small non-coding RNA no previous involvement in tumor Downregulation miR-204 was confirmed an independent cohort patients and cancer cell lines. Gain-of-function analysis indicates that ectopic impairs proliferation, anchorage-independent growth, migration, invasion, formation 3D capillary networks...
Radioresistance of tumor cells gives rise to local recurrence and disease progression in many patients. MicroRNAs (miRNAs) are master regulators gene expression that control oncogenic pathways modulate the radiotherapy response cells. In present study, differential profiling assays identified 16 deregulated miRNAs acquired radioresistant breast cancer cells, which miR-122 was observed be up-regulated. Functional analysis revealed has a role as suppressor parental by decreasing survival...
The anti-inflammatory effect of the cerebral dopamine neurotrophic factor (CDNF) was shown recently in primary glial cell cultures, yet such remains unknown both vivo and 6-hydroxydopamine (6-OHDA) models Parkinson's disease (PD). We addressed this issue by performing an intranigral transfection human CDNF (hCDNF) gene critical period inflammation after a single intrastriatal 6-OHDA injection rat. At day 15 lesion, plasmids p3xNBRE-hCDNF or p3xNBRE-EGFP, coding for enhanced green florescent...
Recently we showed that the neurotensin polyplex is a nanoparticle carrier system targets reporter genes in nigral dopamine neurons vivo. Herein, report its first practical application experimental parkinsonism, which consisted of transfecting with gene coding for human glial cell line-derived neurotrophic factor (hGDNF). Hemiparkinsonism was induced rats by single dose 6-hydroxydopamine (30 microg) into ventrolateral part striatum. We transfection hGDNF substantia nigra 1 week after...
Radiotherapy is an important treatment option for non-small cell lung carcinoma patients. Despite the appropriate use of radiotherapy, radioresistance a biological behavior cancer cells that limits efficacy this treatment. Deregulation microRNAs contributes to molecular mechanism underlying resistance radiotherapy in cells. Although functional roles have been well described cancer, their are largely unclear. In study, we established Calu-1 radioresistant line by continuous exposure...
Models of Parkinson’s disease with neurotoxins have shown that microglial activation does not evoke a typical inflammatory response in the substantia nigra, questioning whether neuroinflammation leads to neurodegeneration. To address this issue, archetypal stimulus, lipopolysaccharide (LPS), was injected into rat nigra. LPS induced fever, sickness behavior, and (OX42 immunoreactivity), followed by astrocyte leukocyte infiltration (GFAP CD45 immunoreactivities). During acute phase...
Neoadjuvant chemotherapy aims to improve the outcome of breast cancer patients, but only few would benefit from this treatment. Pathological complete response has been proposed as a surrogate marker for prediction long-term clinical benefits; however, 50%-85% patients have an unfavorable pathological chemotherapy. MicroRNAs are known biomarkers progression; nevertheless, their potential identify with remains poorly understood. Here, we investigated whether microRNA profile could be...
Vasculogenic mimicry (VM) is a novel cancer hallmark in which malignant cells develop matrix-associated 3D tubular networks with lumen under hypoxia to supply nutrients needed for tumor growth. Recent studies showed that microRNAs (miRNAs) may have role VM regulation. In this study, we examined the relevance of hypoxia-regulated miRNAs (hypoxamiRs) early stages formation. Data after 48 h and 12 incubation on matrigel SKOV3 ovarian undergo formation intercellular connections referred...
Individual differences in cognitive performance are partly dependent, on genetic polymporhisms. One of the single-nucleotide polymorphisms (SNP) CNR1 gene, which codes for cannabinoid receptor 1 (CB1R), is rs2180619, located a regulatory region this gene (6q14-q15). The alleles rs2180619 A > G; G allele has been associated with addiction and high levels anxiety (when interacts SS genotype 5-HTTLPR gene). However, GG observed also healthy subjects. Considering as risk 'psychopathological...
Prophylactic subacute administration of zinc decreases lipoperoxidation and cell death following a transient cerebral hypoxia-ischemia, thus suggesting neuroprotective preconditioning effects. Chemokines growth factors are also involved in the effect hypoxia-ischemia. We explored whether prevents cortex-hippocampus injury through regulation CCL2, CCR2, FGF2, IGF-1 expression 10 min common carotid artery occlusion (CCAO). Male rats were grouped as follows: (1) Zn96h, injected with ZnCl 2 (one...
The structural effect of neurturin (NRTN) on the nigrostriatal dopaminergic system in animals remains unknown, although NRTN has been shown to be effective Parkinson's disease animal models. Herein, we aimed demonstrate that overexpression neurons stimulates both neurite outgrowths pathway and striatal dendritic spines aging rats with chronic 6-hydroxydopamine (6-OHDA) lesion. At week 12 after lesion, pTracer-mNRTN-His or pGreenLantern-1 plasmids were intranigrally transfected using...
In the cerebral hypoxia‐ischemia rat model, prophylactic administration of zinc can cause either cytotoxicity or preconditioning effect, whereas therapeutic selenium decreases ischemic damage. Herein, we aimed to explore whether supplementation low doses and could protect from a transient hypoxic‐ischemic event. We administrated (0.2 mg/kg body weight; ip) daily for 14 days before 10 min common carotid artery occlusion (CCAO). After CCAO, sodium selenite (6 μ g/kg 7 days. temporoparietal...
Human amniotic membrane-derived mesenchymal stem cells (hAM-MSCs) are a potential source of for therapeutic applications in bone regeneration. Recent evidence reveals role microRNAs (miRNAs) the fine-tuning regulation osteogenesis (osteomiRs) suggesting that they can be targets skeleton diseases treatment. However, functions osteomiRs during differentiation hAM-MSCs to osteogenic lineage poorly understood. In this investigation, we discovered novel miRNAs expression signature corresponding...
The transient hypoxic-ischemic attack, also known as a minor stroke, can result in long-term neurological issues such memory loss, depression, and anxiety due to an increase nitrosative stress. individual or combined administration of chronic prophylactic zinc therapeutic selenium is reduce stress the first seven days post-reperfusion and, antioxidant effect, prevent cell death. Besides, selenium, individually administered, causes antidepressant anxiolytic effects. Therefore, this work...
Perinatal asphyxia in the neonatal brain triggers a robust inflammatory response which nitric oxide (NO) generation plays hazardous role. Increased levels of NO can be maintained by activity inducible synthase (NOS2A) on its own or activated IL-1beta (IL-1β) gene transcription and positive back stimulation NOS2 (CCTTT)n microsatellite IL-1β, thus potentiating injury after ischemic perinatal asphyxia. We investigated whether risk for cerebral palsy (CP) increases when an expansion - 2.5 kb...
The aim of this study was to explore whether interactions between FTO rs9939609 and ABCA1 rs9282541 affect BMI waist circumference (WC), could explain previously reported population differences in FTO-obesity FTO-BMI associations the Mexican European populations. A total 3938 adults 636 school-aged children from Central Mexico were genotyped for both polymorphisms. Subcutaneous visceral adipose tissue biopsies 22 class III obesity patients analyzed mRNA expression. Generalized linear models...
Exercise performance and zinc administration individually yield a protective effect on various neurodegenerative models, including ischemic brain injury. Therefore, this work was aimed at evaluating the combined of subacute prophylactic swimming exercise in transient cerebral ischemia model. The (2.5 mg/kg body weight) provided every 24 h for four days before 30 min common carotid artery occlusion (CCAO), after reperfusion, rats were subjected to Morris Water Maze (MWM). Learning evaluated...