A5002560267- Cancer Risks and Factors
- Global Cancer Incidence and Screening
- Breast Cancer Treatment Studies
- Colorectal Cancer Screening and Detection
- BRCA gene mutations in cancer
- Nutritional Studies and Diet
- Childhood Cancer Survivors' Quality of Life
- Cancer Genomics and Diagnostics
- Nutrition, Genetics, and Disease
- Genetic factors in colorectal cancer
- Glutathione Transferases and Polymorphisms
- Pharmacogenetics and Drug Metabolism
- Acute Lymphoblastic Leukemia research
- Metabolism, Diabetes, and Cancer
- Genomics, phytochemicals, and oxidative stress
- Cancer survivorship and care
- Economic and Financial Impacts of Cancer
- Cancer, Lipids, and Metabolism
- Estrogen and related hormone effects
- Vitamin D Research Studies
- Inflammatory mediators and NSAID effects
- Growth Hormone and Insulin-like Growth Factors
- Epigenetics and DNA Methylation
- Cutaneous Melanoma Detection and Management
- Gene expression and cancer classification
University of Utah
2015-2024
Huntsman Cancer Institute
2014-2024
Nottingham Trent University
2024
The University of Adelaide
2023
London Cancer
2021
London School of Hygiene & Tropical Medicine
2020-2021
Utah Cancer Specialists
2015-2020
Centre International de Recherche sur le Cancer
2017
National Cancer Institute
2017
Fundación para la Investigación, Docencia y Prevención del Cáncer
2017
Cancer is a major cause of death in children worldwide, and the recorded incidence tends to increase with time. Internationally comparable data on childhood cancer past two decades are scarce. This study aimed provide internationally local promote research causes implementation control.
Abstract The BRAF V600E mutation has been associated with microsatellite instability and the CpG island methylator phenotype (CIMP) in colon cancer. We evaluated a large population-based sample of individuals cancer to determine its relationship survival other clinicopathologic variables. was seen 5% (40 803) microsatellite-stable tumors 51.8% (43 83) microsatellite-unstable tumors. In tumors, this related poor survival, CIMP high, advanced American Joint Committee on Cancer (AJCC) stage,...
Survival from metastatic cutaneous melanoma is substantially lower than for localized disease. Treatments have been limited, but remarkable clinical improvements reported in trials the last decade. We described characteristics of US patients diagnosed with during 2001-2013 and assessed trends short-term survival distant-stage disease.Trends 1-year net were estimated using Pohar Perme estimator, controlling background mortality life tables all-cause rates by county residence, single year age,...
Cigarette smoking has been associated with microsatellite instability in sporadic colon cancer. Most microsatellite-unstable cancers have widespread methylation of CpG islands (i.e., the island methylator phenotype [CIMP]), and many these tumors harbor V600E BRAF mutation. We investigated whether association between all could be explained through induction CIMP and/or mutations.We evaluated 1315 case patients cancer 2392 control subjects a population-based study. Demographic information,...
To examine the association of alcohol consumption after breast cancer diagnosis with recurrence and mortality among early-stage survivors.Patients included 1,897 LACE study participants diagnosed between 1997 2000 recruited on average 2 years postdiagnosis, primarily from Kaiser Permanente Northern California Cancer Registry. Alcohol (ie, wine, beer, liquor) was assessed at cohort entry using a food frequency questionnaire. Cox proportional hazards models were used to estimate hazard ratios...
The elderly population, including many who are long-term cancer survivors, is increasing. Aspects of quality life in survivors not well understood.Subjects were women enrolled a population-based cohort study 1986. At follow-up 1997, 25,719 women, at median age 72 years, reported on functional limitations. We used logistic regression to calculate prevalence odds ratios (ORs) and proportional hazards (PRs) for associations between survivor status limitations, adjusting baseline (precancer)...
Abstract It has been proposed that dietary factors such as folate, alcohol and methionine may be associated with colon cancer because of their involvement in DNA methylation processes. Data from a large population‐based case‐control study incident were used to evaluate whether intake dietary, obesity, physical activity nonsteroidal antiinflammatory drugs are CpG island methylator phenotype (CIMP). The BRAF V600E mutation 5 markers (MINT1, MINT2, MINT31, p16 hMLH1 ) assessed 1154 cases...
Abstract The 21-gene Recurrence Score assay is validated to predict recurrence risk and chemotherapy benefit in hormone-receptor-positive (HR+) invasive breast cancer. To determine prospective breast-cancer-specific mortality (BCSM) outcomes by baseline results clinical covariates, the National Cancer Institute collaborated with Genomic Health 14 population-based registries Surveillance, Epidemiology, End Results (SEER) Program electronically supplement cancer surveillance data results....
<h3>Background</h3> Metformin has been proffered as a therapy for adolescent obesity, although long-term controlled studies have not reported. <h3>Objective</h3> To test the hypothesis that 48 weeks of daily metformin hydrochloride extended release (XR) will reduce body mass index (BMI) in obese adolescents, compared with placebo. <h3>Design</h3> Multicenter, randomized, double-blind, placebo-controlled clinical trial. <h3>Setting</h3> The 6 centers Glaser Pediatric Research Network from...
Abstract Background: Data are lacking to describe gene expression–based breast cancer intrinsic subtype patterns for population-based patient groups. Methods: We studied a diverse cohort of women with from the Life After Cancer Epidemiology and Pathways studies. RNA was extracted 1 mm punches fixed tumor tissue. Quantitative reverse-transcriptase PCR conducted 50 genes that comprise PAM50 classifier. Results: In subcohort 1,319 women, overall distribution based on 53.1% luminal A, 20.5% B,...
Abstract Kidney cancer incidence rates in the United States have been increasing and are not fully accounted for by better diagnostic techniques. Risk factors women incompletely described. A total of 34,637 Iowan initially free completed a mailed questionnaire 1986. was identified over 15 years follow‐up ( n = 124) through linkage to statewide registry. Adjusted age other risk factors, kidney associated positively with maximum adult weight p trend 0.02) current waist‐to‐hip ratio 0.002)....
Abstract Relationships between adenomatous polyposis coli (APC) mutations, BRAF V600E and the CpG island methylator phenotype (CIMP) in colon cancer have not been explored. In addition, controversies exist about proportion of tumors with APC mutations mutation cluster region (MCR); how commonly APC, Ki-ras, p53 occur same tumor; whether sporadic microsatellite-unstable tumors. The gene was therefore sequenced 90 colonic adenocarcinomas previously evaluated for CIMP, microsatellite...
The proximate cause of cancer cell death by radiation therapy and a number therapeutic agents is through generation reactive oxygen species, resulting in DNA damage as well mitochondrial membrane disruption, triggering the apoptotic cascade. Because manganese superoxide dismutase catalyzes conversion radicals to H(2)O(2), with catalase neutralizing H(2)O(2) myeloperoxidase converting highly hypochlorous acid, we hypothesized that gene variants could impact efficacy treatment for breast...
PURPOSE: Differences in acquired mutations colon and rectal tumors may account for differences risk factors. In this study, we examined similarities somatic alterations tumors. METHODS: Cases were identified from two large population-based case-control studies of cancer cancer. We sequenced Exons 5 to 8 the p53 gene Codons 12 13 Ki-ras identify tumor mutations. Microsatellite instability was determined based on BAT26 TGFβRII analysis; CpG island methylator phenotype having or more following...
Cultural differences in diet and lifestyle patterns probably contribute to cancer rates among ethnic groups the United States. In this paper, we describe physical activity of Hispanic non-Hispanic white women living southwestern States effects these on obesity.We use data from population-based controls (N = 2039) participating 4-Corner's Breast Cancer Study evaluate associations between language acculturation associated obesity.The majority both did not perform 30 min > or 5 d x wk(-1),...