A5074197949- Parkinson's Disease Mechanisms and Treatments
- Statistical Methods and Bayesian Inference
- Statistical Methods and Inference
- Neurological disorders and treatments
- Statistical Methods in Clinical Trials
- RNA modifications and cancer
- Dementia and Cognitive Impairment Research
- Epigenetics and DNA Methylation
- Ferroptosis and cancer prognosis
- Autism Spectrum Disorder Research
- Bayesian Methods and Mixture Models
- Cancer-related molecular mechanisms research
- Health Systems, Economic Evaluations, Quality of Life
- Pancreatic and Hepatic Oncology Research
- Genetic Associations and Epidemiology
- Aquaculture disease management and microbiota
- Cancer Immunotherapy and Biomarkers
- Advanced Causal Inference Techniques
- Lung Cancer Research Studies
- Cerebral Palsy and Movement Disorders
- Botulinum Toxin and Related Neurological Disorders
- Neuroendocrine Tumor Research Advances
- Alzheimer's disease research and treatments
- Additive Manufacturing and 3D Printing Technologies
- Balance, Gait, and Falls Prevention
Duke University
2018-2025
Army Medical University
2025
Lanzhou Jiaotong University
2025
Ningbo University
2021-2024
National University of Singapore
2023-2024
Central China Normal University
2024
Institute of Crop Sciences
2024
Chinese Academy of Agricultural Sciences
2024
Duke Medical Center
2018-2024
Hubei University of Medicine
2020-2024
Background: Genetic instability associated with telomere dysfunction (i.e., short telomeres) is an early event in tumorigenesis. We investigated the association between length and cancer risk four ongoing case–control studies. Methods: All studies had equal numbers of case patients matched control subjects (92 for head neck cancer, 135 bladder 54 lung 32 renal cell carcinoma). Telomere was measured peripheral blood lymphocytes from study participants. assessed comet assay. Patient disease...
<h3>Importance</h3> There are no treatments available to slow or prevent the progression of Parkinson disease, despite its global prevalence and significant health care burden. The National Institute Neurological Disorders Stroke Exploratory Trials in Disease program was established promote discovery potential therapies. <h3>Objective</h3> To determine whether creatine monohydrate more effective than placebo slowing long-term clinical decline participants with disease. <h3>Design, Setting,...
Experimental studies and small clinical trials have suggested that treatment with intranasal oxytocin may reduce social impairment in persons autism spectrum disorder. Oxytocin has been administered practice to many children
Background: Research-based exercise interventions improve health-related quality of life (HRQL) and mobility in people with Parkinson's disease (PD). Objective: To examine whether habits were associated changes HRQL over two years. Methods: We identified a cohort Na tional Parkinson Foundation Quality Improvement Initiative (NPF-QII) participants three visits. measured the Disease Questionnaire (PDQ-39) Timed Up Go (TUG). compared self-reported regular exercisers (≥2.5 hours/week) who did...
Purpose Prediction of patients at highest risk for ipsilateral breast tumor recurrence (IBTR) after local excision ductal carcinoma in situ (DCIS) remains a clinical concern. The aim our study was to evaluate published nomogram from Memorial Sloan-Kettering Cancer Center predict IBTR with DCIS institution. Patients and Methods We retrospectively identified 794 diagnosis who had undergone 1990 through 2007 the MD Anderson (MDACC). Clinicopathologic factors performance prediction were assessed...
Background: Identifying predictors of conversion to Alzheimer’s disease (AD) is critically important for AD prevention and targeted treatment. Objective: To compare various clinical biomarker trajectories tracking progression predicting from amnestic mild cognitive impairment probable AD. Methods: Participants were the ADNI-1 study. We assessed ability 33 longitudinal biomarkers predict time conversion, accounting demographic genetic factors. used joint modelling survival data examine...
Neurodegenerative disorders such as Alzheimer's disease (AD) present a significant global health challenge, characterized by cognitive decline, functional impairment, and other debilitating effects. Current AD clinical trials often assess multiple longitudinal primary endpoints to comprehensively evaluate treatment efficacy. Traditional methods, however, may fail capture effects, require larger sample sizes due multiplicity adjustments, not fully utilize the available data. To address these...
Purpose American Joint Committee on Cancer (AJCC) staging is used to determine breast cancer prognosis, yet patient survival within each stage shows wide variation. We hypothesized that differences in biology influence this variation and addition of biologic markers AJCC improves determination prognosis. Patients Methods identified a cohort 3,728 patients who underwent surgery as the first intervention between 1997 2006. A Cox proportional hazards model, with backward stepwise exclusion...
Background The Liver Imaging Reporting and Data System (LI-RADS) treatment response algorithm (TRA) is used to assess presumed hepatocellular carcinoma (HCC) after local-regional therapy, but its performance has not been extensively assessed. Purpose To the of LI-RADS version 2018 TRA in evaluation HCC ablation. Materials Methods In this retrospective study, patients who underwent ablation therapy for followed by liver transplantation between January 2011 December 2015 at a single tertiary...
Optimizing assessments of rate progression in Parkinson disease (PD) is important designing clinical trials, especially potential disease-modifying agents.To examine the value measures impairment, disability, and quality life assessing early PD.Inception cohort analysis data from 413 patients with early, untreated PD who were enrolled 2 multicenter, randomized, double-blind trials.Participants randomly assigned to 1 5 treatments (67 received creatine, 66 minocycline, 71 coenzyme Q10,...
As an increasing number of patients exhibit concomitant cardiac and pulmonary disease, limitations standard diagnostic criteria are more frequently encountered. Here, we apply noninvasive 129Xe magnetic resonance imaging (MRI) spectroscopy to identify patterns regional gas transfer impairment haemodynamics that uniquely associated with chronic obstructive disease (COPD), idiopathic fibrosis (IPF), left heart failure (LHF) arterial hypertension (PAH).Healthy volunteers (n=23) COPD (n=8), IPF...
Background Current imaging methods for prediction of complete margin resection (R0) in patients with pancreatic ductal adenocarcinoma (PDAC) are not reliable. Purpose To investigate whether tumor-related and perivascular CT radiomic features improve preoperative assessment arterial involvement surgically proven PDAC. Materials Methods This retrospective study included consecutive PDAC who underwent surgery after between 2012 2019. A three-dimensional segmentation tissue surrounding the...
In Brief Objective: To classify ipsilateral breast tumor recurrences (IBTR) as either new primary tumors (NP) or true local recurrence (TR). We utilized 2 different methods and compared sensitivities specificities between them. Our goal was to determine whether distinguishing NP from TR had prognostic value. Background: After breast-conservation therapy, IBTR may be classified into distinct types (NP TR). Studies have attempted by using location, histologic subtype, DNA flow cytometry data,...
Images, often stored in multidimensional arrays, are fast becoming ubiquitous medical and public health research. Analyzing populations of images is a statistical problem that raises host daunting challenges. The most significant challenge the massive size datasets incorporating recorded for hundreds or thousands subjects at multiple visits. We introduce population value decomposition (PVD), general method simultaneous dimensionality reduction large images. show how PVD can be seamlessly...
The Movement Disorder Society (MDS)-sponsored revision of the Unified Parkinson's Disease (PD) Rating Scale (UPDRS) (MDS-UPDRS) has been developed and is now available in English. Part overall program includes establishment official non-English translations MDS-UPDRS. We present process for completing Japanese translation MDS-UPDRS with clinimetric testing results.In this trial, was translated into Japanese, underwent cognitive pre-testing, modified after taking results account. final...
Covariance estimation is essential yet underdeveloped for analyzing multivariate functional data. We propose a fast covariance method sparse data using bivariate penalized splines. The tensor-product B-spline formulation of the proposed enables simple spectral decomposition associated operator and explicit expressions resulting eigenfunctions as linear combinations bases, thereby dramatically facilitating subsequent principal component analysis. derive algorithm selecting smoothing...
Racial and ethnic minorities have been underrepresented in Parkinson disease (PD) research, limiting our understanding of treatments outcomes across all non-White groups. The goal this research is to investigate variability health-related quality life (HRQoL) other patients with PD different races ethnicities.
Abstract Background There is a causal link between childhood socioeconomic status and health in adulthood beyond. It's vital to comprehend the relationship mental among older Chinese individuals from current generation who have undergone significant social changes China. This understanding critical foster healthy demographic development Methods Using data 2020 China Family Panel Studies, we investigate depression adults. Additionally, examine mediating role of adult subjective well-being....