A5011751620- Neurological disorders and treatments
- Parkinson's Disease Mechanisms and Treatments
- Functional Brain Connectivity Studies
- Memory and Neural Mechanisms
- Advanced NMR Techniques and Applications
- Biochemical and Molecular Research
- Neurobiology of Language and Bilingualism
- Epilepsy research and treatment
- Advanced MRI Techniques and Applications
- Enzyme Structure and Function
- Memory Processes and Influences
- NMR spectroscopy and applications
- RNA modifications and cancer
- DNA and Nucleic Acid Chemistry
- Electron Spin Resonance Studies
- Attention Deficit Hyperactivity Disorder
- Protein Structure and Dynamics
- Muscle metabolism and nutrition
- Amino Acid Enzymes and Metabolism
- Transcranial Magnetic Stimulation Studies
- RNA and protein synthesis mechanisms
- Cancer, Hypoxia, and Metabolism
- Dementia and Cognitive Impairment Research
- Neuroscience and Neuropharmacology Research
- Psychopathy, Forensic Psychiatry, Sexual Offending
Krembil Research Institute
2017-2024
Krembil Foundation
2019-2024
University of Toronto
2015-2024
Ontario Brain Institute
2020-2024
Toronto Western Hospital
2008-2024
University Health Network
2014-2024
Krembil Brain Institute
2021-2023
University of Pennsylvania
1975-2023
University of Florida
2023
Shirley Ryan AbilityLab
2023
Abstract Bilateral hypothalamic deep brain stimulation was performed to treat a patient with morbid obesity. We observed, quite unexpectedly, that evoked detailed autobiographical memories. Associative memory tasks conducted in double‐blinded “on” versus “off” manner demonstrated increased recollection but not familiarity‐based recognition, indicating functional engagement of the hippocampus. Electroencephalographic source localization showed drove activity mesial temporal lobe structures....
In 2 experiments, the authors investigated whether impaired strategic retrieval processes contribute to age-related deficit in associative memory. To do so, they compared older and younger adults on measures of memory that place high demands (associative identification recall-to-reject) low such reinstatement recall-to-accept). Results showed were severely recall-to-reject measures; relatively intact recall-to-accept measures, unless recollection was prominent; measures. Together, these...
Abstract 31P NMR studies with Cd(II) and Zn(II) chelates of adenosine 5'-O-(3-thiotriphosphate) (ATPgammaS) the chelate 5'-O-(2-thiotriphosphate) (ATPbetaS) indicate that these metal ions to sulfur atom thiophosphate group. Since Mg(II) oxygen group diastereoisomer is equivalent configuration opposite diastereoisomer. As a consequence, an inversion stereospecificity observed when substituted for in phosphoryl transfer reactions catalyzed by yeast hexokinase rabbit muscle pyruvate kinase....
Summary Purpose The clinical relevance of resting state functional connectivity in neurologic disorders, including mesial temporal lobe epilepsy ( mTLE ), remains unclear. This study investigated how the default mode network changes with unilateral damage to one its nodes, hippocampus HC and such can be exploited clinically characterize memory deficits indicate postsurgical change. Methods Functional magnetic resonance imaging (fMRI) scans neuropsychological assessments (Warrington...
This study was designed to examine whether proactive and reactive aggression are meaningful distinctions at the variable- person-based level, determine their associated behavioral profiles. Data from 587 adolescents (mean age 15.6; 71.6 % male) clinical samples of four different sites with differing levels problems were analyzed. A multi-level Latent Class Analysis (LCA) conducted identify classes individuals (person-based) similar profiles based on factor scores (variable-based) Reactive...
Despite a wealth of EEG epilepsy data that accumulated for over half century, our ability to understand brain dynamics associated with remains limited. Using from 15 controls and 9 left temporal lobe (LTLE) patients, in this study we characterize how the healthy differ "dynamically balanced" state patients treated anti-epileptic drugs context resting state. We show such differences can be observed band power, synchronization network measures, as well deviations small world (SWN) architecture...
Computational models predict that focal damage to the Default Mode Network (DMN) causes widespread decreases and increases of functional DMN connectivity. How such alterations impact functioning in a specific cognitive domain as episodic memory remains relatively unexplored. Here, we show patients with unilateral medial temporal lobe epilepsy (mTLE) structural leads indeed patterns connectivity alterations, specifically decreased between both lobes (MTLs) posterior part increased...
Quantitative probing of heterogeneous regions in muscle is feasible with phosphorus-31 magnetic resonance spectroscopy because the differentiation metabolic patterns glycolytic and oxidative fibers. A differential recruitment fibers during exercise was demonstrated 4 10 untrained young men by following changes phosphate metabolites. Concentrations inorganic (Pi), phosphocreatine, ATP were estimated wrist flexor muscles forearm at rest, two cycles three grades exercise, recovery. At high work...
Children diagnosed with Disruptive Behavior Disorders (DBD), especially those psychopathic traits, are at risk of developing persistent and severe antisocial behavior. Deficient fear conditioning may be a key mechanism underlying persistence, has been associated altered regional brain function in adult populations. In this study, we investigated the associations between neural correlates conditioning, persistence childhood-onset DBD during adolescence traits. From cohort children arrested...
Racial and ethnic minorities have been underrepresented in Parkinson disease (PD) research, limiting our understanding of treatments outcomes across all non-White groups. The goal this research is to investigate variability health-related quality life (HRQoL) other patients with PD different races ethnicities.
Growth rate inhibition of subcutaneously implanted tumors results from feeding rats and athymic nude mice diets containing 1% cyclocreatine or 1%, 2%, 5%, 10% creatine. The studied included rat mammary (Ac33tc in Lewis female 13762A Fischer 344 rats), sarcoma MCI male rats, resulting the injection two human neuroblastoma cell lines, IMR-5 CHP-134, mice. Inhibition was observed regardless time experimental were administered, either at tumor implantation after appearance palpable tumors. For...
The paramagnetic effects of the bound manganese ion and a covalently attached spin label on proton nuclear relaxation rates have been used to calculate distances for structural model MnADP creatine complexed kinase from rabbit muscle. nucleotide guanidino substrates are so aligned enzyme that transferable phosphoryl group one substrate is in apposition acceptor moiety second substrate. divalent metal most probably liganded alpha beta phosphates substrate, both abortive MnADP-creatine-enzyme...
The environments of the two sulfhydryl groups procine muscle adenylate kinase have been investigated by chemical modification reactions. results indicate that two-SH are markedly different and substrates induce conformational changes in enzyme region groups. fluorogenic reagent 7-chloro-4-nitrobenzo-2-oxa-1, 3-diazole (NBD-chloride) reacts specifically with -SH at pH 7.9. One thiol group NBD-chloride approximately 40-fold faster than other one, fast reacting has identified as Cys-25 amino...
Porcine muscle adenylate kinase with a molecular weight of 22,000 has 2 histidine, 5 phenylalanine, 7 tyrosine, and no tryptophan residues. The effect pH, substrate, the paramagnetic manganous ion on proton magnetic resonance spectrum enzyme, particularly aromatic region, been investigated at 220 MHz. well resolved C2 peaks histidine residues have individually assigned to His-36 His-189 by comparison carp enzyme which only one peak 1 residue, 36. chemical shift designated C2-H in porcine...
The arginine kinase reaction, the reversible transfer of terminal phosphoryl group ATP to L-arginine, has been investigated by technique 31P NMR at catalytic and stoichiometric concentrations enzyme. Three four substrates, ATP, ADP, P-arginine produce easily distinguishable resonances in spectrum, thus permitting a determination equilibrium constants from integrated areas resonances. From linewidths, exchange rates between reactants products may be evaluated. At pH 7.25 temperature 12...