A5004491112- Genetic Associations and Epidemiology
- Epigenetics and DNA Methylation
- Smoking Behavior and Cessation
- Cervical Cancer and HPV Research
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Genetic Mapping and Diversity in Plants and Animals
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Head and Neck Cancer Studies
- Global Cancer Incidence and Screening
- BRCA gene mutations in cancer
- Lung Cancer Diagnosis and Treatment
- Nutritional Studies and Diet
- Glioma Diagnosis and Treatment
- Gene expression and cancer classification
- Genetic and phenotypic traits in livestock
- Hepatitis B Virus Studies
- Behavioral Health and Interventions
- Lung Cancer Treatments and Mutations
- Bioinformatics and Genomic Networks
- MicroRNA in disease regulation
- Genomic variations and chromosomal abnormalities
- Vaccine Coverage and Hesitancy
- Health Literacy and Information Accessibility
- Genetic Syndromes and Imprinting
The University of Texas MD Anderson Cancer Center
2016-2025
Harvard University
2012-2024
The University of Texas Health Science Center at Houston
2001-2024
Datta Meghe Institute of Medical Sciences
2023
Cancer Research And Biostatistics
2017-2021
Anderson University - South Carolina
2021
University of Oslo
2017
Centre for Life
2016
Newcastle University
2016
Dartmouth College
2016
Abstract Purpose: The purpose of this study was to test the hypothesis that circulating tumor cells (CTCs) are present in patients many years after mastectomy without evidence disease and these CTCs shed from persisting with breast cancer dormancy. Experimental Design: We searched for 36 dormancy candidate 26 age-matched controls using stringent criteria cytomorphology, immunophenotype, aneusomy. Results: Thirteen candidates, 7 22 clinical disease, had CTCs, usually on more than one...
The vascular smooth muscle cell (SMC)-specific isoform of alpha-actin (ACTA2) is a major component the contractile apparatus in SMCs located throughout arterial system. Heterozygous ACTA2 mutations cause familial thoracic aortic aneurysms and dissections (TAAD), but only half mutation carriers have disease. Linkage analysis association studies individuals 20 families with indicate that can diversity diseases, including premature onset coronary artery disease (CAD) ischemic strokes (including...
Amplification and overexpression of the HER-2 oncogene in breast cancer is felt to be stable over course disease concordant between primary tumor metastases. Therefore, patients with -negative tumors rarely will receive anti-Her-2 antibody (trastuzumab, Herceptin) therapy. A very sensitive blood test was used capture circulating cells (CTCs) evaluate their gene status by fluorescence situ hybridization. The corresponding CTCs 31 showed 97% agreement, no false positives. In 10 -positive...
BackgroundReliable risk prediction tools for estimating individual probability of lung cancer have important public health implications. We constructed and validated a comprehensive clinical tool by smoking status.
Background— A genetic predisposition for progressive enlargement of thoracic aortic aneurysms leading to type dissection (TAAD) is inherited in an autosomal-dominant manner up 19% patients, and a number chromosomal loci have been identified the condition. Having mapped TAAD locus 3p24–25, we sequenced gene transforming growth factor-β receptor II ( TGFBR2 ) determine whether mutations this resulted familial TAAD. Methods Results— We all 8 coding exons by using genomic DNA from 80 unrelated...
Several national health care-based smoking cessation initiatives have been recommended to facilitate the delivery of evidence-based treatments, such as quitline (telephone-based tobacco services) assistance. The most notable examples are 5 As (Ask, Advise, Assess, Assist, Arrange) and Ask. Advise. Refer. (AAR) programs. Unfortunately, rates primary care referrals quitlines low, referred smokers fail call for assistance.To evaluate a new approach--Ask-Advise-Connect (AAC)--designed address...
The aim was to determine the proportions and correlates of essential hypertension among children in a tertiary pediatric clinic. We evaluated 423 consecutive collected demographic clinical history by retrospective chart review. identified 275 (65%) hypertensive (blood pressure >95th percentile per “Fourth Report on Diagnosis, Evaluation, Treatment High Blood Pressure Children Adolescents”) from referred clinic for elevated blood pressure. remainder patients had normotension (11%), white coat...
Gliomas are the most common brain tumor, with several histological subtypes of various malignancy grade. The genetic contribution to familial glioma is not well understood. Using whole exome sequencing 90 individuals from 55 families, we identified two families mutations in POT1 (p.G95C, p.E450X), a member telomere shelterin complex, shared by both affected each family and predicted impact DNA binding TPP1 binding, respectively. Validation separate cohort 264 246 an additional mutation...
Pain is a complex human trait. It likely that the interaction of multiple genes, each with small individual effect, along effect environmental factors, influences clinical efficacy opioids rather than single gene alone. Polymorphisms in genes coding for mu-opioid receptor (A118G) and catechol-O-methyl transferase (Val158Met) may be important modulators opioid efficacy. We assessed joint effects OPRM1 COMT predicting morphine dose cancer pain relief. used genotype data from pharmacokinetic...
DNA repair capacity (DRC) plays an important role in genetic susceptibility to cancer. Polymorphisms of a number genes involved several distinct pathways have been identified. However, their effects on function not well characterized. We demonstrated previously that DRC for removal benzo[a]pyrene diol epoxide-induced damage measured by host-cell reactivation assay was modulated two XPD/ERCC2 polymorphisms lung In this report, we investigated the association between phenotype ultraviolet...
Background —Aneurysms and dissections affecting the ascending aorta are associated primarily with degeneration of aortic media, called medial necrosis. Families identified dominant inheritance thoracic aneurysms (TAA/dissections) indicate that single gene mutations can cause necrosis in absence an syndrome. Methods Results —Fifteen families were multiple members TAAs/dissections. DNA from affected 2 was used for a genome-wide search location defective by use random polymorphic markers. The...
<h3>Objective</h3> To determine human leucocyte antigen-class II (HLA-class II) (DRB1, DQB1, DQA1 and DPB1) alleles, haplotypes shared epitopes associated with scleroderma (systemic sclerosis (SSc)) its subphenotypes in a large multi-ethnic US cohort by case–control association study. <h3>Patients methods</h3> 1300 SSc cases (961 white, 178 black 161 Hispanic subjects) characterised for clinical skin forms (limited vs diffuse), SSc-specific autoantibodies (anticentromere (ACA),...
Hypertrophic cardiomyopathy (HCM) is a genetic disorder caused by mutations in sarcomeric proteins (excluding phenocopy). The causal genes approximately one-third of the cases remain unknown. We identified family comprised 6 clinically affected members. phenotype was characterized early onset symptoms, pronounced cardiac hypertrophy, and arrhythmias. excluded MYH7, MYBPC3, TNNT2, ACTC1 as gene either direct sequencing or haplotype analysis. To map putative candidate gene, we perforbold...
While gliomas are the most common primary brain tumors, their etiology is largely unknown. To identify novel risk loci for glioma, we conducted genome-wide association (GWA) analysis of two case–control series from France and Germany (2269 cases 2500 controls). Pooling these data with previously reported UK US GWA studies provided on 4147 glioma 7435 controls genotyped 424 460 tagging single-nucleotide polymorphisms. Using data, demonstrate statistically independent associations between...
Breast cancer diagnosis and treatment can have a profound influence on woman's physical, psychosocial, overall well-being. We examined the prevalence of depressive symptoms its association with health-related quality life (HRQOL) in women who are survivors breast cancer. also assessed if factors, including metastasis, recurrence, new primary cancers, comorbid conditions, associated symptoms.The Patient Health Questionnaire (PHQ-8) European Organization for Research Treatment Cancer Quality...