A5034011636- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Pituitary Gland Disorders and Treatments
- Head and Neck Surgical Oncology
- RNA modifications and cancer
- Radiomics and Machine Learning in Medical Imaging
- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Neurofibromatosis and Schwannoma Cases
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Cerebrospinal fluid and hydrocephalus
- Bone Tumor Diagnosis and Treatments
- MicroRNA in disease regulation
- Vascular Malformations Diagnosis and Treatment
- Brain Metastases and Treatment
- Genomic variations and chromosomal abnormalities
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Immunotherapy and Immune Responses
- Sarcoma Diagnosis and Treatment
- Neurogenesis and neuroplasticity mechanisms
- Cancer, Lipids, and Metabolism
- Axon Guidance and Neuronal Signaling
- Pelvic floor disorders treatments
Baylor College of Medicine
2015-2025
St. Luke's Hospital
2024
Neurological Surgery
2022-2024
The University of Texas MD Anderson Cancer Center
2015-2020
Cornell University
2019
Weill Cornell Medicine
2019
Northwestern University
2004-2015
McGill University Health Centre
2015
Iran University of Medical Sciences
2015
Shiraz University of Medical Sciences
2015
Abstract There is a critical need to improve our understanding of the pathogenesis melanoma brain metastases (MBM). Thus, we performed RNA sequencing on 88 resected MBMs and 42 patient-matched extracranial metastases; tumors with sufficient tissue also underwent whole-exome sequencing, T-cell receptor IHC. demonstrated heterogeneity immune infiltrates that correlated prior radiation post-craniotomy survival. Comparison identified significant immunosuppression enrichment oxidative...
Gliomas are the most common brain tumor, with several histological subtypes of various malignancy grade. The genetic contribution to familial glioma is not well understood. Using whole exome sequencing 90 individuals from 55 families, we identified two families mutations in POT1 (p.G95C, p.E450X), a member telomere shelterin complex, shared by both affected each family and predicted impact DNA binding TPP1 binding, respectively. Validation separate cohort 264 246 an additional mutation...
Abstract Immunotherapy targeting T cells is increasingly utilized to treat solid tumors including non-small cell lung cancer (NSCLC). This requires a better understanding of the in lungs patients with NSCLC. Here, we report repertoire analysis cohort 236 early-stage NSCLC patients. attributes are associated clinicopathologic features, mutational and immune landscape. A considerable proportion most prevalent also uninvolved tumor-adjacent appear specific shared background mutations or viral...
Meningiomas account for one-third of all primary brain tumors. Although typically benign, about 20% meningiomas are aggressive, and despite the rigor current histopathological classification system there remains considerable uncertainty in predicting tumor behavior. Here, we analyzed 160 tumors from 3 World Health Organization (WHO) grades (I through III) using clinical, gene expression, sequencing data. Unsupervised clustering analysis identified molecular types (A, B, C) that reliably...
Epithelial tumor cells undergo epithelial-to-mesenchymal transition (EMT) to gain metastatic activity. Competing endogenous RNAs (ceRNAs) have binding sites for a common set of microRNAs (miRs) and regulate each other's expression by sponging miRs. Here, we address whether ceRNAs govern metastasis driven the EMT-activating transcription factor ZEB1. High miR-181b levels were correlated with an improved prognosis in human lung adenocarcinomas, cell lines derived from murine adenocarcinoma...
Astrocytes are critical for the development and function of synapses. There notable species differences between human astrocytes commonly used animal models. Yet, it is unclear whether astrocytic genes involved in synaptic stable or exhibit dynamic changes associated with disease states age humans, which a barrier understanding astrocyte biology its potential involvement neurologic diseases. To better understand properties astrocytes, we acutely purified from cerebral cortices over 40 humans...
Abstract Background Metastasis is the primary cause of cancer mortality accounting for 90% deaths. Our understanding molecular mechanisms driving metastasis rudimentary. Results We perform whole exome sequencing (WES), RNA sequencing, methylation microarray, and immunohistochemistry (IHC) on 8 pairs non-small cell lung (NSCLC) tumors matched distant metastases. Furthermore, we analyze published WES data from 35 NSCLC pairs, transcriptomic 4 autopsy cases with metastatic one mouse model. The...
We performed whole-exome sequencing of a family with autosomal dominant Dandy-Walker malformation and occipital cephaloceles detected mutation in the extracellular matrix (ECM) protein-encoding gene NID1. In second family, protein interaction network analysis identified LAMC1, which encodes NID1-binding partner. Structural modeling NID1-LAMC1 complex demonstrated that each disrupts interaction. These findings implicate ECM pathogenesis spectrum disorders.
Background The shelterin complex is composed of six proteins that protect and regulate telomere length, including protection telomeres 1 (POT1). Germline POT1 mutations are associated with an autosomal dominant familial cancer syndrome presenting diverse malignancies, glioma, angiosarcoma, colorectal melanoma. Although somatic promote elongation genome instability in chronic lymphocytic leukaemia, the contribution to development other sporadic cancers largely unexplored. Methods We performed...
Members of the Hes and Hey families basic helix-loop-helix transcription factors are regarded as Notch target genes that generally inhibit neuronal differentiation neural progenitor cells. We found HeyL, contrary to classic function factors, promotes cells both in culture embryonic brain vivo. Furthermore, null mutation HeyL decreased rate cultured binds activates promoter proneural gene neurogenin2, which is inhibited by other family members, a weak inhibitor Hes1 promoter. able bind but it...
Epigenetic dysregulation is a universal feature of cancer that results in altered patterns gene expression drive malignancy. Brain tumors exhibit subtype-specific epigenetic alterations; however, the molecular mechanisms responsible for these diverse states remain unclear. Here, we show developmental transcription factor Sox9 differentially regulates epigenomic high-grade glioma (HGG) and ependymoma (EPN). Using our autochthonous mouse models, found suppresses HGG growth expands associated...
Background: The standard surgical option for symptomatic Rathke's cleft cysts involves an endoscopic endonasal approach cyst fenestration and drainage. In the absence of intraoperative CSF leak, dural defect is often not repaired. reported rates postoperative leaks range from 0 to 21%, majority patients who developed these presented within 3 months surgery. There has been only one case a delayed leak in literature; however, there have no cases with associated encephalocele through after fenestration.
Glioblastoma is the deadliest primary brain tumor, largely due to inevitable recurrence of disease after treatment. While most recurrences are local, patients rarely present with a new discontiguous focus glioblastoma. Little currently known about genetic profile recurrences. In our institutional database, we identified 22 targeted exome sequencing pairs initial and recurrent IDH-wildtype Recurrences were classified as contiguous or based on presence absence T2 FLAIR signal connection site...
INTRODUCTION: Recent literature has highlighted neural signaling markers (SM) as drivers for synaptogenesis, invasion, and proliferation in gliomas. Further work on elucidating key mutations can provide not only improved prognostication but also potential treatment targets. METHODS: We used a combination of bulk RNA sequencing (RNA-seq) DNA gene panel (DPG) by Tempus next-generation sequencing. Differential expression (DGE) was performed using DESeq2 after subsetting genes SM. Dimensionality...
Since its introduction, digital subtraction angiography has been considered the gold standard in diagnostic imaging for neurovascular disease. Modern post-processing techniques have made even more informative to cerebrovascular neurosurgeon or neurointerventionalist. Open neurosurgical procedures such as aneurysm clipping, extirpation of arteriovenous malformations, and extracranial-intracranial bypass remain important armamentarium a comprehensive neurosurgeon. In-depth study anatomy...
Abstract Glioma is a rare, but highly fatal, cancer that accounts for the majority of malignant primary brain tumors. Inherited predisposition to glioma has been consistently observed within non-syndromic families. Our previous studies, which involved non-parametric and parametric linkage analyses, both yielded significant peaks on chromosome 17q. Here, we use data from next generation Sanger sequencing identify familial candidate genes variants 17q further investigation. We applied...