A5100342954- Xenotransplantation and immune response
- Pharmacological Effects of Natural Compounds
- Organ Transplantation Techniques and Outcomes
- Liver physiology and pathology
- Tissue Engineering and Regenerative Medicine
- MicroRNA in disease regulation
- Ginseng Biological Effects and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Circular RNAs in diseases
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- CRISPR and Genetic Engineering
- Oral microbiology and periodontitis research
- Inflammatory Biomarkers in Disease Prognosis
- Electrospun Nanofibers in Biomedical Applications
- Cardiovascular Function and Risk Factors
- Animal Genetics and Reproduction
- Organ Donation and Transplantation
- Neuropeptides and Animal Physiology
- Cancer, Stress, Anesthesia, and Immune Response
- Steroid Chemistry and Biochemistry
- Hippo pathway signaling and YAP/TAZ
- Phytochemistry and biological activity of medicinal plants
- Berberine and alkaloids research
Air Force Medical University
2016-2025
Xijing Hospital
2016-2025
Tianjin Internal Combustion Engine Research Institute
2024
China Automotive Technology and Research Center
2024
Jiangsu University
2024
Second Affiliated Hospital of Jilin University
2023
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine
2023
South China Agricultural University
2022
Hainan Medical University
2022
Lanzhou University of Technology
2020
The shortage of donors is a major challenge for transplantation; however, organs from genetically modified pigs can serve as ideal supplements1,2. Until now, porcine hearts and kidneys have been successively transplanted into humans3–7. In this study, heterotopic auxiliary transplantation was used to donate six-gene-edited pig liver brain-dead recipient. graft function, haemodynamics, immune inflammatory responses the recipient were monitored over subsequent 10 days. Two hours after portal...
Aim: We aimed to identify the roles of circRHOT1 in pancreatic cancer. Materials & methods: The was acquired from our previous study followed by quantitative real-time PCR and fluorescence situ hybridization validation used siRNA shRNA explore function cancer cells. Bioinformatic analyses were applied potential mechanism circRHOT1. Results: upregulated predominantly located cytoplasm. Reducing expression may inhibit cell proliferation, invasion migration. play a role through binding miR-26b,...
Abstract Autophagy is a life phenomenon in which autophagosomes remove damaged or aging organelles and long‐lived circulating proteins to maintain the cell's stability. However, disorders of excessive autophagy are response cancer cells variety anticancer treatments lead cell death. The Akt/mammalian target rapamycin ( mTOR ) extracellular signal‐regulated kinase 1/2 ERK 1/2) pathways both involved nutrient‐induced autophagic exhibit vital relevance oncogenesis various types, including...
The molecular signaling events involving in high malignancy and poor prognosis of hepatocellular carcinoma (HCC) are extremely complicated. Blockade currently known targets has not yet led to successful clinical outcome. More understanding about the regulatory mechanisms HCC is necessary for developing new effective therapeutic strategies patients. expression Rho GTPase-activating protein 11A (ARHGAP11A) was examined human normal liver tissues. correlations between ARHGAP11A...
Abstract Background The prognosis of hepatocellular carcinoma (HCC) is not optimistic. Our study focused on present inflammatory markers, including the neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), gamma-glutamyl transpeptidase-to-platelet (GPR), aspartate aminotransferase-to-lymphocyte (ALR) and fibrinogen-to-albumin (FAR), explored their optimal combination for HCC after resection. Methods A total 347 patients who underwent curative resection were enrolled. cutoff...
Abstract Background Pig‐to‐nonhuman primate orthotopic liver xenotransplantation is often accompanied by thrombocytopenia and coagulation disorders. Furthermore, the release of cytokines can trigger cascade reactions immune attacks within transplant recipients. To better elucidate process inflammation in xenograft recipients, we utilized a modified heterotopic auxiliary model for xeno‐immunological research. We studied cytokine profiles relationship between levels function after...
The extraction kinetics and thermodynamic parameters of Glycyrrhiza polysaccharide (GP) were studied, its rheological properties antiviral activity evaluated.
Abstract Background Oxidative stress and inflammation promote the development of diabetic cardiomyopathy (DCM). Therefore, inhibiting these processes may show beneficial effects in treatment patients with DCM. Taohuajing (THJ) is prepared using Persicae semen (Taoren), Polygonatum sibiricum (Huangjing), Carthami flos (Honghua) have applications However, protective THJ not been thoroughly assessed. Accordingly, this study, we aimed to investigate a model DCM further clarify potential...
Abstract Translationally controlled tumor protein (TCTP), which is a characterized by its potent proliferation promoting activity, has been well studied in the area of growth and tumorigenesis. However, specific role TCTP liver regeneration (LR) underlying mechanism remains unclear. In order to investigate contribution during LR, heterozygous mice were generated, mimic LR model was applied TCTP-knockdown (KD) hepatic cell lines. The results revealed that TCTP-KD impaired mice, manifested as...
Background: BTBD10 serves as an activator of Akt family members through decreasing the protein phosphatase 2A-mediated dephosphorylation. The present study attempted to investigate prognostic value in hepatocellular carcinoma (HCC), specially, its relationship with tumor-infiltrating lymphocytes (TILs). Methods: expression was evaluated HCC using Cancer Genome Atlas (TCGA) and Xijing Hospital database, verified cell lines. Cox analyses were performed analyze independent risk factors for HCC....
The present study investigated the effects and potential mechanisms of action magnesium isoglycyrrhizinate (MgIG) in doxorubicin (DOX)-treated mice. Histopathological analysis western blot were conducted liver heart tissues biochemical serum was performed. results revealed that MgIG (10, 20 40 mg/kg/day) could protect structure functions by inhibiting activities myocardial enzymes creatine kinase (CK), CK-MB lactate dehydrogenase hepatic-specific aspirate aminotransferase alanine...