A5100746534- Cancer-related molecular mechanisms research
- Cancer Cells and Metastasis
- Cancer Immunotherapy and Biomarkers
- Inflammasome and immune disorders
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Bone Metabolism and Diseases
- Ferroptosis and cancer prognosis
- Traditional Chinese Medicine Studies
- COVID-19 Impact on Reproduction
- Healthcare and Venom Research
- Bone health and treatments
- Advanced biosensing and bioanalysis techniques
- Cancer survivorship and care
- Electrocatalysts for Energy Conversion
- Cytomegalovirus and herpesvirus research
- Traditional Chinese Medicine Analysis
- Monoclonal and Polyclonal Antibodies Research
- RNA modifications and cancer
- HER2/EGFR in Cancer Research
- Cancer-related Molecular Pathways
- Psoriasis: Treatment and Pathogenesis
- interferon and immune responses
- Pain Mechanisms and Treatments
- Cancer Research and Treatments
Chinese Academy of Medical Sciences & Peking Union Medical College
2016-2025
Peking Union Medical College Hospital
2014-2024
Xiangya Hospital Central South University
2008-2023
Central South University
2008-2023
Binzhou Medical University
2023
Sun Yat-sen University
2022-2023
Capital Medical University
2018-2022
Harbin Veterinary Research Institute
2022
Chinese Academy of Agricultural Sciences
2022
Shihezi University
2007-2022
The coronavirus disease 2019 (COVID-19) pandemic remains threatening to women and children, but clinical evidence regarding during pregnancy, puerperium lactation is limited. We assessed immunologic features of breastfeeding advice provided mother–infant pairs. This observational analysis was conducted in a tertiary-care centre Wuhan, China. Pregnant patients with laboratory-confirmed COVID-19 who delivered hospitalization were enrolled. Clinical characteristics serial specimens the pairs...
Reactive oxygen species can lead to functional alterations in lipids, proteins, and nucleic acids, an accumulation of ROS (Reactive species) is considered be one factor that contributes neurodegenerative changes. An increase production occurs following irradiation. Neuronal tissue susceptible oxidative stress because its high consumption modest antioxidant defenses. As a polyphenolic compound, resveratrol frequently used as activator Sirt1 (Sirtuin 1). The present study was designed explore...
Background Colorectal cancer (CRC) is a major burden of public health and healthcare worldwide. Microbiota has been suggested in promoting chronic inflammation the intestine which, turn, promotes tumor development. This study focuses on possible correlations human papillomavirus (HPV) infection with proinflammatory Stat3 signaling activities resulting levels its downstream cytokine IL-17 CRC patients. Methods HPV was examined using Genotyping Chip technology constitutively active (p-Stat3)...
Summary Little is known about the risk factors associated with hepatitis B virus ( HBV ) intrauterine transmission among HB sAg‐positive mothers. We conducted a study in Taiyuan, China, including 1133 mothers and their babies. A total of 101 neonates had sAg and/or DNA positive an rate 8.9%. Maternal menstrual irregularity OR = 4.95, 95% CI : 1.71, 14.33) severe nausea during first trimester 1.86, 1.11, 3.09) were increased transmission, while caesarean delivery 0.32, 0.20, 0.51) was...
Abstract RNA binding proteins (RBPs)-mediated post-transcriptional control has been implicated in influencing various aspects of metabolism and playing important roles mammalian development pathological diseases. However, the functions specific RBPs molecular mechanisms through which they act monocyte/macrophage differentiation remain to be determined. In this study, bioinformatics analysis experimental validation, we identify that ZFP36L1, a member ZFP36 zinc finger protein family, exhibits...
In this study, we applied laser capture microdissection and a proteomic approach to identify novel nasopharyngeal carcinoma (NPC) biomarkers. Proteins from pooled microdissected NPC normal epithelial tissues (NNET) were separated by two-dimensional gel electrophoresis, differential proteins identified mass spectrometry. Expression of the protein cathepsin D in above two as well four cell lines was determined Western blotting. Next, siRNA used inhibit expression highly metastatic line 5−8F...
Abstract Background Psoriasis is a chronic immune‐mediated skin disorder. Systemic inflammation plays an important role in the pathogenesis of psoriasis. Methods A total 477 patients with psoriasis vulgaris (PsV, n = 347), generalized pustular (GPP, 37), erythrodermic (PsE, 45), arthritic (PsA, 25) and mixed ( 23), 954 healthy control subjects were included study. Demographic, clinical, laboratory information collected compared between subgroups. Results Compared group, had higher white...
Tumour-associated macrophages (TAMs) play an important role in the growth, progression, and metastasis of tumours. Epithelial-mesenchymal transition (EMT) is a mechanism for tumour invasion metastasis. In this study, we aimed to determine whether TAMs can induce EMT Kazakh oesophageal squamous cell cancer (ESCC).CD163 was used as marker TAMs, density nest surrounding stroma quantified using immunohistochemistry (IHC). IHC staining evaluate expression E-cadherin (epithelial marker) vimentin...
Objective: To explore the clinicopathological features of rectal neuroendocrine tumor (R-NET) G2, identify prognostic factors, and summarize treatment experience. Methods: The clinical data patients diagnosed with R-NET G2 by pathological diagnosis admitted to Cancer Hospital Chinese Academy Medical Sciences from January 2003 September 2023 were retrospectively analyzed. Fisher's exact test Kaplan-Meier curves performed analyze association between prognosis. Results: A total 22 enrolled in...
Abstract Emerging evidence suggests that activation of the Notch1 signaling pathway inducing epithelial to mesenchymal transition (EMT) mediated by Snail/Slug promotes invasion and metastasis breast cancer cells in vitro . However, implication Notch1‐Snail/Slug‐EMT axis patients remains unclear. A total 200 formalin‐fixed paraffin‐embedded samples invasive ductal carcinoma (IDC), 37 adjacent non‐neoplastic tissue (ANNT) from who had not been treated with neoadjuvant therapy were examined....
CD133, a glycoprotein, is expressed in different types of human stem cells and tumor cells. Detection altered CD133 expression colorectal cancer tissues could be useful as marker for the prediction tumorigenesis, progression, prognosis.A total 19 fresh 145 paraffin-embedded tissue specimens from patients were obtained detection using flow cytometry immunohistochemistry, respectively. The tumorigenic capacity was assessed nude mice. Association then analyzed clinical significance.The...
Immunotherapy has developed rapidly and gradually become one of the important methods for treatment gastric cancer (GC). The research on tumor infiltrating immune cells (TIICs) immune-related genes in microenvironment (TME) greatly encourages development immunotherapy. devolution algorithm (CIBERSORT) was applied to infer proportion 22 TIICs based gene expression profiles GC tissues, which were downloaded from TCGA GEO. utilized analyze differential genes, explore potential molecular...
Anaplastic thyroid carcinoma (ATC) is an aggressive malignant disease in older adults with a high mortality rate. The present study aimed to examine several key genes and pathways, which are associated ATC. GSE33630 gene expression profile was downloaded from the Gene Expression Omnibus database, included 11 ATC 45 normal samples. differentially expressed (DEGs) were identified using Limma package R. Ontology functions Kyoto Encyclopedia of Genes Genomes pathways selected DEGs enriched...
Accumulating evidence indicates that patients with inflammatory bowel disease (IBD) have a significantly higher risk of developing different cancers, while the exact mechanism involved is not yet fully understood. Malassezia lipid-dependent opportunistic yeast, which colonizes on mammalian skin and internal organs. Also, dysbiosis in fungal communities accompanied by high level are fairly common diseases such as IBD various cancers. In cancer patients, levels associated worse prognosis. Once...
Whether metagenomic next-generation sequencing (mNGS) could benefit patients with suspected severe central nervous system (CNS) infection in terms of diagnosis and antibiotic treatment remains unknown. We retrospectively analyzed 79 CNS undertook mNGS. The value mNGS was investigated identification pathogen guidance for the adjustment treatment. relationship between time initiating since onset Glasgow Outcome Scale (GOS) score after 90-day follow-up were analyzed. Fifty out cases suspicious...
Alternative pre-mRNA splicing is a key mechanism for increasing proteomic diversity and modulating gene expression. Emerging evidence indicated that the program frequently dysregulated during tumorigenesis. Cancer cells produce protein isoforms can promote growth survival. The RNA-binding QKI5 critical regulator of alternative in expanding lists primary human tumors tumor cell lines. However, its biological role regulatory are poorly defined gastric cancer (GC) development progression. In...
Abstract Background Oxidative stress and inflammation promote the development of diabetic cardiomyopathy (DCM). Therefore, inhibiting these processes may show beneficial effects in treatment patients with DCM. Taohuajing (THJ) is prepared using Persicae semen (Taoren), Polygonatum sibiricum (Huangjing), Carthami flos (Honghua) have applications However, protective THJ not been thoroughly assessed. Accordingly, this study, we aimed to investigate a model DCM further clarify potential...
CD19 and CD37 proteins are highly expressed in B-cell lymphoma have been successfully targeted with different monotherapies, including chimeric antigen receptor (CAR)-T cell therapy. The goal of this study was to target novel CD37, humanized bi-specific CD37-CD19 CAR-T cells. A mouse monoclonal anti-human antibody (clone 2B8D12F2D4) generated high binding affinity for (KD = 1.6 nM). specifically recognized surface protein cells not multiple myeloma or other types cancer. CD37-CAR-T killed...