A5052950208- Multiple Myeloma Research and Treatments
- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Protein Degradation and Inhibitors
- Cancer therapeutics and mechanisms
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- Gut microbiota and health
- Ubiquitin and proteasome pathways
- Autophagy in Disease and Therapy
- Peptidase Inhibition and Analysis
- Histone Deacetylase Inhibitors Research
- Cancer-related Molecular Pathways
- Drug Transport and Resistance Mechanisms
- Cancer Immunotherapy and Biomarkers
- Cancer, Hypoxia, and Metabolism
- Immune Cell Function and Interaction
- Cancer Genomics and Diagnostics
- RNA Research and Splicing
- Ginger and Zingiberaceae research
- Hedgehog Signaling Pathway Studies
- Cancer Cells and Metastasis
- Influenza Virus Research Studies
- Lung Cancer Research Studies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
Central South University
2016-2025
Liaocheng University
2025
Shanghai Veterinary Research Institute
2024
Chinese Academy of Agricultural Sciences
2024
Ministry of Agriculture and Rural Affairs
2024
First Affiliated Hospital of Shihezi University Medical College
2024
Zhuzhou Central Hospital
2023
Xiangya Hospital Central South University
2018-2023
China Institute of Veterinary Drug Control
2023
National Health and Family Planning Commission
2015-2022
Abstract Background Nasopharyngeal carcinoma (NPC) is a common malignant tumor in southern China and Southeast Asia, but its molecular mechanisms of pathogenesis are poorly understood. Our previous work has demonstrated that BCAT1 mRNA over expressed NPC knocking down expression 5-8F cell line can potently inhibit cycle progression proliferation. However, the mechanism up-regulation functional role development remain to be elucidated yet. Methods Immunohistochemistry (IHC) method was...
Abstract Background Gut microbiome alterations are closely related to human health and linked a variety of diseases. Although great efforts have been made understand the risk factors for multiple myeloma (MM), little is known about role gut its metabolic functions in development MM. Results Here, cohort newly diagnosed patients with MM healthy controls (HCs), significant differences metagenomic composition were discovered, first time, higher bacterial diversity Specifically,...
NEK2 is associated with drug resistance in multiple cancers. Our previous studies indicated that high confers inferior survival myeloma (MM); thus, a better understanding of the mechanisms by which induces MM required. In this study, we discovered enhances cell autophagy, and combination autophagy inhibitor chloroquine (CQ) chemotherapeutic bortezomib (BTZ) significantly prevents NEK2-induced cells. Interestingly, was found to bind stabilize Beclin-1 protein but did not affect its mRNA...
Summary The serine synthesis pathway (SSP) is active in multiple cancers. Previous study has shown that bortezomib (BTZ) resistance associated with an increase the SSP myeloma (MM) cells; however, underlying mechanisms of SSP‐induced BTZ remain unclear. In this study, we found phosphoglycerate dehydrogenase (PHGDH), first rate‐limiting enzyme SSP, was significantly elevated CD138 + cells derived from patients relapsed MM. Moreover, high PHGDH conferred inferior survival We also...
Lung is colonized by a diverse array of microbes and the lung microbiota profoundly involved in development respiratory diseases. There little knowledge about role dysbiosis cancer. In this study, we performed metagenomic sequencing on bronchoalveolar lavage (BAL) from two different sampling methods non-small cell cancer (NSCLC) patients non-cancer controls. We found obvious variation between bronchoscopy samples lobectomy samples. Oral taxa can be both higher abundance oral Although NSCLC...
Abstract As the Human Microbiome Project (HMP) progresses, relationship between microbes and human health has been receiving increasing attention. A growing number of reports support correlation cancer microbes. However, most studies have focused on bacteria, rather than fungal communities. In this study, we studied alteration in lung mycobiome patients with non-small-cell (NSCLC) using metagenomic sequencing qPCR. The higher diversity more complex network were observed NSCLC. addition,...
// Ye Yang 1, * , Wen Zhou Jiliang Xia 1 Zhimin Gu Erik Wendlandt Xin Zhan 2 Siegfried Janz 3 Guido Tricot Fenghuang Department of Internal Medicine, University Iowa Carver College City, United States Vanderbilt University, Nashville, Tennessee, Pathology, Co-first authors Correspondence to: Zhan, email: fenghuang-zhan@uiowa.edu Keywords: Plasma cell myeloma, aldehyde dehydrogenase, NIMA-related kinase, tumor-initiating Received: July 05, 2014 Accepted: August...
Abstract Nasopharyngeal carcinoma (NPC) has the highest rate of metastasis among head and neck cancers, distant is major reason for treatment failure. We have previously shown that high cyclooxygenase‐2 (COX‐2) expression associated with a poor prognosis patients NPC inhibits chemotherapy‐induced senescence in cells. In this study, we found COX‐2 was upregulated cancer‐associated fibroblasts (CAFs) derived from by RNA‐Seq. Furthermore, elevated CAF detected survival using...
Autophagy has been reported to play a dual "double-edged sword" role in the occurrence and development of Alzheimer's disease (AD). To assess relationship between AD autophagy, dynamic changes autophagic flux brain postmortem patients, animal models cell were studied. The results showed that autophagosomes (APs) accumulation expression lysosomal markers decreased brains patients. In APP/PS1 double transgenic mice, APs did not accumulate before formation SPs but accumulated along with...
Abstract It has been previously shown that (never in mitosis gene A)‐related kinase 2 ( NEK2 ) is upregulated multiple myeloma (MM) and contributes to drug resistance. However, the mechanisms behind this upregulation remain poorly understood. In study, it found amplification of hypermethylation distal CpG islands its promoter correlate strongly with increased expression. Patients have a poor rate survival often exhibit TP53 deletion, which an independent prognostic factor MM. This...
Allelic loss of chromosome 3p, including the 3p21.3 region, is found in 95-100% primary nasopharyngeal carcinoma (NPC) biopsies, suggesting that this region should harbor some tumor suppressor genes (TSGs) closely related to NPC development. Several TSGs located at 3p21.3, such as RASSF1A, LTF and BLU, have been demonstrated be involved LARS2 (leucyl-tRNA synthetase 2, mitochondrial) another gene 3 common eliminated region-1 (C3CER1) 3p21.3. In study, we focussed on epigenetic genetic...
Resistance to radiotherapy and chemotherapy currently represents one of the major reasons for therapeutic failure in nasopharyngeal carcinoma (NPC). However, mechanisms underlying resistance NPC remain unclear. In this study, cell counting assay, cycle assay senescence associated β-galactosidase activity were performed evaluate growth, proliferation senescence, respectively. We found that aberrant expression cyclooxygenase-2 (COX-2) was with a poor outcome recurrance patients NPC. cells,...
Recent evidence suggests that Oxymatrine (OMT) has excellent effects in anticancer. The mechanism, however, remains unclear. In the present study, we investigated potential mechanism of OMT against cancer. differential expression miRNA was screened by array. miRNA-520 and VEGF lung cancer assayed real-time PCR, Western blot immunohistochemistry, respectively. direct interaction between luciferase activity assay their roles proliferation, invasion migration were analyzed vivo vitro. We found...
The microfilament cytoskeleton, formed by the process of actin polymerization, serves not only to support morphology cell, but also regulate a number cellular activities. Actin-depolymerizing factors (ADFs) represent significant class actin-binding proteins that dynamic alterations in framework, thereby playing pivotal role plant growth and development. Additionally, they are instrumental modulating stress responses plants. ADF gene family has been explored various plants, there was paucity...
Human leucine zipper transcription factor-like 1 (LZTFL1) is a novel gene with unknown biological functions. It located in the chromosome region 3p21.3, hotspot for tumor suppressor genes. To understand functions of LZTFL1, we surveyed expression level LZTFL1 and normal samples tissue microarrays clinical archive 84 gastric cancer specimens using immunohistochemistry. We found that expressed highly epithelial cells tissues significantly downregulated corresponding samples. The correlated...
The lactoferrin (LTF) gene, located at 3p21.3, behaves like a tumor suppressor gene in diverse tumors. To elucidate the exact role of LTF NPC, we first detected its expression level seven NPC cell lines by semi-quantitative reverse transcription-polymerase chain reaction (RT-PCR). results showed mRNA was nearly undetectable all lines, while it could be chronic nasopharyngitis tissues. Subsequently, used methylation-specific PCR (MSP), microsatellite assay, PCR-single-strand conformation...
Abstract Nasopharyngeal carcinoma (NPC) is a common malignant tumor in southern China and Southeast Asia, but the molecular mechanism of its pathogenesis poorly understood. Our previous work demonstrated that NEK2 overexpressed multiple cancers. However, how involves NPC development remains to be elucidated. In this study, we firstly identified NEK2, located at +1q32‐q33, late event pathogenesis, stage III‐IV paired sequential recurrent patients with by immunohistochemistry. Furthermore,...
Multiple myeloma remains incurable due to the persistence of a minor population multiple cells that exhibit drug resistance, which leads relapsed and/or refractory myeloma. Elucidating mechanism underlying resistance and developing an effective treatment are critical for clinical management Here we showed promoting expression gene polycomb-like protein 3 (PHF19) induced cell growth multidrug in vitro vivo. PHF19 was overexpressed high-risk drug-resistant primary from patients. High levels...