A5037826469- Cancer Genomics and Diagnostics
- Ferroptosis and cancer prognosis
- Multiple Myeloma Research and Treatments
- Bioinformatics and Genomic Networks
- Single-cell and spatial transcriptomics
- Immune cells in cancer
- Antioxidant Activity and Oxidative Stress
- Corneal Surgery and Treatments
- Aquaculture disease management and microbiota
- Corneal surgery and disorders
- Aortic aneurysm repair treatments
- Monoclonal and Polyclonal Antibodies Research
- Cancer Mechanisms and Therapy
- Gut microbiota and health
- Aortic Disease and Treatment Approaches
- Low-power high-performance VLSI design
- Protein Tyrosine Phosphatases
- Identification and Quantification in Food
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Connective tissue disorders research
- Congenital heart defects research
- Surgical site infection prevention
- Immunotherapy and Immune Responses
- Platelet Disorders and Treatments
- Cancer-related molecular mechanisms research
Yunnan Agricultural University
2022-2025
Shanxi Academy of Medical Sciences
2022-2025
Shanxi Medical University
2022-2025
Jiangxi Pingxiang People's Hospital
2025
Central South University
2019-2023
Shanghai Center For Bioinformation Technology
2018-2023
Shanghai Academy of Science & Technology
2018-2023
Richard L. Roudebush VA Medical Center
2023
Indiana University Health
2023
Indiana University – Purdue University Indianapolis
2023
Abstract Metabolites in the tumor microenvironment are a critical factor for progression. However, lack of knowledge about metabolic profile bone marrow (BM) multiple myeloma (MM) limits our understanding MM Here, we show that glycine concentration BM is elevated due to collagen degradation mediated by cell-secreted matrix metallopeptidase 13 (MMP13), while level linked cells utilize channel protein solute carrier family 6 member 9 (SLC6A9) absorb extrinsic subsequently involved synthesis...
The occurrence of hepatocellular carcinoma (HCC) related to liver cirrhosis is mostly accompanied by extensive immune infiltration. To reveal the infiltration cells landscape, single-cell RNA sequencing data from healthy donor (HD), patients with (LC) and HCC were collected for analysis. By drawing a cell map calculating proportion each type, total B identified significant higher in (24.26%) than LC (5.41%) HD (5.82%), which plasma account 97.1% HCC. While HCC, TCGA datasets taken further...
Abstract Thrombocytopenia is a major complication in subset of patients with multiple myeloma (MM). However, little known about its development and significance during MM. Here, we show thrombocytopenia linked to poor prognosis In addition, identify serine, which released from MM cells into the bone marrow microenvironment, as key metabolic factor that suppresses megakaryopoiesis thrombopoiesis. The impact excessive serine on mainly mediated through suppression megakaryocyte (MK)...
Abstract It has been previously shown that (never in mitosis gene A)‐related kinase 2 ( NEK2 ) is upregulated multiple myeloma (MM) and contributes to drug resistance. However, the mechanisms behind this upregulation remain poorly understood. In study, it found amplification of hypermethylation distal CpG islands its promoter correlate strongly with increased expression. Patients have a poor rate survival often exhibit TP53 deletion, which an independent prognostic factor MM. This...
Neoantigens are widely reported to induce T-cell response and lead tumor regression, indicating a promising potential immunotherapy. Previously, we constructed an open-access database, i.e., dbPepNeo, providing systematic resource for human neoantigens storage query. In order expand data volume application scope, updated dbPepNeo version 2.0 ( http://www.biostatistics.online/dbPepNeo2 ). Here, provide about 801 high-confidence (HC) (increased by 170%) 842,289 low-confidence (LC) HLA...
Interplay between gut microbiota and heart, termed "gut-heart" axis, has a crucial role in the pathogenesis of atherosclerosis. Our previous study showed that lycopene possesses anti-inflammatory anti-atherosclerotic effects, but its link to is poorly understood. Herein, we surmised could regulate microbiota, exert effect by regulating axis.Male ApoE-/- mice were fed high-fat diet (HFD) with or without (0.1% w/w) for 19 weeks. Gut was analyzed 16 S rRNA sequencing, protein levels zonula...
Our previous study showed that lycopene reduced the absorption of cholesterol in Caco-2 cells through inhibiting Niemann-Pick C1-Like 1 (NPC1L1) expression. Herein, we aimed to explore whether supplementation can decrease intestine and prevent atherosclerosis progression high-fat diet (HFD)-fed apolipoprotein E knockout (ApoE–/–) mice. Male ApoE–/– mice were fed a with or without for 19 weeks. Supplementation markedly lowered serum total low-density lipoprotein (LDL-C) levels. Additionally,...
Stanford-A Aortic dissection (TAAD) is a rare and fatal disease, genetic factors remains poorly known. Study has confirmed that lncRNA play an important role in various physiological pathological processes. This study attempts to elucidate the underlying molecular mechanisms of TAAD through lncRNA-associated competitive endogenous RNA (ceRNA) networks. In this study, aortic vascular 5 control (ischemic heart disease) were subjected mRNA microarray analysis, differentially expressed mRNAs...
The heterogeneity and intricate cellular architecture of complex ecosystems play a crucial role in the progression therapeutic response cancer. Understanding regulatory relationships malignant cells at invasive front tumor microenvironment (TME) is important to explore TME its disease progression. In this study, we inferred invasion by analyzing single-cell RNA sequencing (scRNA-seq) spatial transcriptomics (ST) data ER-positive (ER+) breast cancer patients. addition, developed software...
Aging-related diseases, which are associated with the senescence of endothelial progenitor cells (EPCs), consistently accompanied by elevated levels circulating trimethylamine-N-oxide (TMAO), a marker predictive poor prognosis. Lycopene (Lyc) deficiency has been demonstrated to be linked these age-related diseases. The AMPK/SIRT1 pathway plays pivotal role in cellular senescence. In this study, we hypothesize that lycopene could mitigate TMAO-induced EPCs senescence, involvement pathway....
Patients with cancer different molecular characterization and subtypes result in response to anticancer therapeutics survival. To identify features that are associated prognosis is essential precision medicine by providing clues for target identification, drug discovery. Here, we developed a tumor online prognostic analysis platform (ToPP) which integrated eight multi-omics clinical data from 68 projects. It provides multiple approaches customized studies, including 1) Prognostic based on...
A proteogenomics-based neoantigen prediction pipeline, namely ProGeo-neo, was previously developed by our team to predict neoantigens, allowing the identification of class-I major histocompatibility complex (MHC) binding peptides based on single-nucleotide variation (SNV) mutations. To improve it, we here present an updated i.e., ProGeo-neo v2.0, in which a one-stop software solution proposed identify neoantigens paired tumor-normal whole genome sequencing (WGS)/whole exome (WES) data FASTQ...
Adolescent idiopathic scoliosis (AIS) is the most common pediatric spine disorder, affecting ~3% of children worldwide. Human genetic studies suggest complex polygenic disease model for AIS with large and phenotypic heterogeneity. However, overall etiology remains poorly understood. To identify additional susceptibility loci, we performed whole exome sequencing (WES) on a cohort 195 southern Chinese patients. Bioinformatics analysis identified 237 novel rare variants associated AIS, located...
Background: As a major subtype of ovarian cancer, high grade FIGO stage IIIc serous carcinoma (HG3cSOC), has various prognosis due to genetic heterogeneity. Methods: The transcriptome 401 primary samples was screened, seven genes based prognostic model developed. valueof risk score in four different cohorts (TCGA-cohort, Poland-cohort, Japan-cohort and USA-cohort) validated. relationship between other clinical indicators were analyzed. guide value for platinum-taxol chemotherapy also...
The heterogeneity of tumor microenvironment (TME) hepatocellular carcinoma (HCC) may relate to cell-cell interaction event (CCE) dysregulation and would affect therapeutic responses clinical outcomes. To reveal the differentiation CCEs in liver tissue from healthy donors (HD) HCC, scRNA-seq data ~62000 cells HD, paracancerous nontumor (NT), HCC were analyzed. microenvironmental CCE landscape was constructed. Dysregulated cell types changed molecular functions identified with alterations HCC....
Cell-cell interaction event (CCEs) dysregulation may relate to the heterogeneity of tumor microenvironment (TME) and would affect therapeutic responses clinical outcomes. To reveal alteration immune in bone marrow from a healthy state multiple myeloma (MM), scRNA-seq data four states, including normal (NBM) three disease states (MGUS, SMM, MM), were collected for analysis. With reconstruction, cell types, NK cells, CD8+ T CD4+ with higher percentage associated prognosis MM patients....
Background: At present, the diagnosis of tuberculosis (TB) is still challenging, and improving efficiency can help prevent control TB. This retrospective clinical study aimed to assess diagnostic GeneXpert MTB/RIF for pulmonary Methods: A total 620 newly-diagnosed patients who visited clinic Shanghai Tongren Hospital between 2018 2021 were enrolled in study. All had acid-fast Bacilli (AFB) identified by Ziehl Neelsen staining (ZNS) test, BECTEC MGIT 960 liquid culture (LC), assay (GX). 53...
The striped scat Selenotoca multifasciata is an ornamental and commercial fish in Asia. In the present study, we sequenced annotated complete mitochondrial genome of multifasciata. Its total length 16,646 bp, composed 13 protein-coding genes, 2 rRNA 22 tRNA genes a non-coding control region. ND6 eight were encoded on light strand, whereas remaining located heavy strand (H-strand). All 16 genomes suborder Acanthuroidei available GenBank employed for phylogenetic analysis, result showed close...