A5103098498- Ultrasonics and Acoustic Wave Propagation
- Non-Destructive Testing Techniques
- Geophysical Methods and Applications
- Monoclonal and Polyclonal Antibodies Research
- Structural Health Monitoring Techniques
- Concrete and Cement Materials Research
- HER2/EGFR in Cancer Research
- CAR-T cell therapy research
- Welding Techniques and Residual Stresses
- Concrete Corrosion and Durability
- Quantum Information and Cryptography
- Biochemical and Structural Characterization
- Optical measurement and interference techniques
- Smart Materials for Construction
- Thermography and Photoacoustic Techniques
- Pneumonia and Respiratory Infections
- Seismic Waves and Analysis
- Quantum optics and atomic interactions
- Immunotherapy and Immune Responses
- Mechanical and Optical Resonators
- Respiratory and Cough-Related Research
- Heat Transfer and Boiling Studies
- Peptidase Inhibition and Analysis
- Photoacoustic and Ultrasonic Imaging
- Fatigue and fracture mechanics
Second Affiliated Hospital of Zhejiang University
2025
Dalian University of Technology
2014-2024
Zhejiang University
2016-2024
Hunan Children's Hospital
2013-2024
Dalian University
2018-2024
Nanjing University of Chinese Medicine
2024
Zhejiang Province Institute of Architectural Design and Research
2020
Beijing University of Technology
2020
Zhejiang Chinese Medical University
2016-2019
Shandong Normal University
2017
Antibody-drug conjugate (ADC) targeting antigens expressed on the surface of tumor cells are an effective approach for delivering drugs into via antigen-mediated endocytosis. One well-known antigens, CD20 B-lymphocyte, has long been suggested to be noninternalizing epitope, and is thus not considered a desirable target ADCs. Here, sortase A (srtA)-mediated transpeptidation used specifically triple glycine-modified monomethyl auristatin E (MMAE), highly toxic antimitotic agent, anti-CD20...
Abstract Ultrasonic testing (UT) is increasingly combined with machine learning (ML) techniques for intelligently identifying damage. Extracting significant features from UT data essential efficient defect characterization. Moreover, the hidden physics behind ML unexplained, reducing generalization capability and versatility of methods in UT. In this paper, a generally applicable framework based on model interpretation strategy proposed to improve detection accuracy computational efficiency...
Aluminum alloy is widely applied to the aerospace field. However, inspection of thin plates using Time-of-Flight Diffraction (TOFD) technique restricted by near-surface dead zone because coupling between diffracted longitudinal wave and lateral wave. The half-skip mode-converted introduced decrease detect defects in aluminum increasing ray path propagation time. quantitative correlation for shear from back-wall deduced combination with acoustic path, realizing accurate location shallow...
Abstract The shallow subsurface defects are difficult to be identified and quantified by ultrasonic time-of-flight diffraction (TOFD) due the low resolution induced pulse width beam spreading. In this paper, Sparse-SAFT is proposed improve time lateral in TOFD imaging combining sparse deconvolution synthetic aperture focusing technique (SAFT). mathematical model frequency domain established based on l 1 2 norm constraints, optimization problem solved for enhancing resolution. On basis, SAFT...
The therapeutic efficacy of antibodies can be successfully improved through targeted delivery potent cytotoxic drugs in the form antibody-drug conjugates. However, conventional conjugation strategies lead to heterogeneous conjugates with undefined stoichiometry and sites, even considerable batch-to-batch variability. In this study, we have developed a chemo-enzymatic strategy by equipping C-terminus anti-CD20 ofatumumab click handle using Sortase A, followed ligation payload based on...
Early diagnosis of Severity Mycoplasma Pneumoniae Pneumonia (SMPP) has been a worldwide concern in clinical practice. Two cytokines, soluble Triggering Receptor Expressed on Myeloid cells (sTREM-1) and Interferon-Inducible Protein-10 (IP-10), were proved to be implicated bacterial infection diseases. However, the diagnostic value sTREM-1 IP-10 MPP was poorly known. This study aimed investigate for SMPP. In this prospective study, authors enrolled 44 children with MPP, along their...
Limited clinical application of antibody-drug conjugates (ADCs) targeting tumor associated antigens (TAAs) is usually caused by on-target off-tumor side effect. Tumor-specific mutant (TSMAs) only expressed in cells which are ideal targets for ADCs. In addition, intracellular somatic proteins can be presented on the cell surface human leukocyte antigen class I (HLA I)molecules forming tumor-specific peptide/HLA complexes. KRAS G12V mutation frequently occurred varied cancer and was verified...
Bronchial asthma is a chronic disease which currently treated using various inhalants. However, the medication adherence with inhalants poor due to complex procedure use them along frequent dosing. In this paper, we have developed tulobuterol loaded Pluronic® F127-reduced graphene oxide transdermal hydrogel sustain release of manage for days. The synthesis was confirmed by Fourier transform infrared spectroscopy, X-ray diffraction, and Raman spectroscopy. transmission electron microscope...