A5100356085- Flavonoids in Medical Research
- Curcumin's Biomedical Applications
- Andrographolide Research and Applications
- Natural product bioactivities and synthesis
- Medical Research and Treatments
- Genomics, phytochemicals, and oxidative stress
- Neuroinflammation and Neurodegeneration Mechanisms
- Traditional Chinese Medicine Analysis
- Insect and Arachnid Ecology and Behavior
- Traditional Chinese Medicine Studies
- Cannabis and Cannabinoid Research
- Phytochemistry and Biological Activities
- Retinoids in leukemia and cellular processes
- Pharmacological Effects of Natural Compounds
- Mesenchymal stem cell research
- Bee Products Chemical Analysis
- Toxin Mechanisms and Immunotoxins
- PARP inhibition in cancer therapy
- Berberine and alkaloids research
- Insect and Pesticide Research
- Phytochemistry Medicinal Plant Applications
- Advancements in Transdermal Drug Delivery
- Synthesis and Characterization of Heterocyclic Compounds
- Gut microbiota and health
- Health and Well-being Studies
Western Sydney University
2022-2025
Central Hospital of Wuhan
2025
Chengdu Third People's Hospital
2025
Southwest Jiaotong University
2025
Taiyuan University of Technology
2024
First Hospital of Shanxi Medical University
2024
Shanxi Medical University
2021-2024
Heilongjiang University
2024
Yichun University
2023
Southern Medical University
2023
Oral leukoplakia (OLK), an uncharacterized pathological condition that occurs as a white patch in the oral mucosa, is most common precancerous condition. Scutellaria baicalensis Georgi (SBG) medicinal plant with wide range of pharmacological effects. Increased evidence shows SBG has potential therapeutic effects on OLK. However, mechanisms against OLK have not yet been completely elucidated.This study aimed to clarify active components and multi-target via network pharmacology, molecular...
Curcumin, a natural polyphenol antioxidant extracted from the root of turmeric ( Curcuma longa ), can induce apoptosis and DNA demethylation in several types cancer cells. However, mechanism its anticancer potentials effects potential relationships between these outcomes have not been clearly elucidated. In present study, curcumin on proliferation, colony formation, migration human gastric cells (hGCCs) were explored. Reactive oxygen species (ROS) levels, mitochondrial damage,...
Metabolic associated fatty liver disease (MAFLD) is the most common chronic that has no viable treatment. Curcumin (Cur) and resveratrol (Res) are two natural products have been studied for their potential to ameliorate MAFLD. However, while these compounds investigated individually, combined use a synergistic or augmented effect remain unexplored. This study aims investigate of curcumin as combination therapy on Cur, Res Cur+Res were tested in palmitic acid (PA)-induced-HepG2 cells. MAFLD...
In the present study, bee pollen polysaccharides from Rosa rugosa (WRPP) were extracted and fractionated. WRPP purified to neutral (WRPP-N) acidic (WRPP-1, WRPP-2) with DEAE-Cellulose. WRPP-N mainly composed of glucose, mannose, arabinose galactose, indicating existence glucan, arabinogalactan (AG) mannoglucan. WRPP-1 consisted rhamnose (3.0%), galacturonic acid (12.4%), galactose (24.7%) (53.9%), contained a large proportion AGs. WRPP-2 (7.8%), (23.0%), (15%) (48.7%), while more compared...
β-elemene, extracted from herb medicine Curcuma wenyujin has potent anti-tumor effects in various cancer cell lines. However, the activity of β-elemene against glioma cells remains unclear. In present study, we assessed on human and explored underlying mechanism.Human U87 were used. Cell proliferation was determined with MTT assay colony formation to detect effect at different doses times. Fluorescence microscopy used observe apoptosis Hoechst 33258 staining change cycling analyzed by flow...
Epidemiological investigations show that long-term exposure to PM2.5 is directly related asthma-like and other respiratory diseases. This study aims further explore the pharmacological effect of Ephedra sinica polysaccharide (ESP) on lung injury caused by atmospheric PM2.5.To achieve aim, we explored therapeutic ESP an aggravated mouse induced combined with ovalbumin (OVA), mechanisms underlying connection between gut microbiota function.Preliminary results showed alleviated symptoms...
Abstract Hepatocellular carcinoma (HCC) is a common malignancy affecting many people worldwide. Baicalin flavonoid extracted from the dried root of Scutellaria baicalensis Georgi . It can effectively inhibit occurrence and development HCC. Nonetheless, mechanism through which inhibits HCC growth metastasis remain unknown. This work discovered that inhibited cell proliferation, invasion, while inducing cycle arrest at G0/G1 phase apoptosis. In vivo xenograft results indicated growth. Western...
BACKGROUND The prevalence of peripheral arterial disease (PAD) is increasing worldwide. Currently, there no effective treatment for PAD. Curcumin an ingredient turmeric that has antioxidant, anti-inflammation, and anticancer properties. In the present study we investigated potential effect curcumin in protecting against ischemic limb injury. MATERIAL AND METHODS We used established hindlimb ischemia mouse model our study. was administrated through intraperitoneal (I.P.) injection....
Uterine necrosis following cesarean section is an extremely rare but serious complication. This case report presents a unique scenario where cross binding suture technique was employed to manage intractable postpartum hemorrhage (PPH), ultimately leading uterine and hysterectomy. The underscores the challenges of managing severe PPH highlights potential complications unconventional surgical techniques. It also emphasizes importance early recognition intervention minimize maternal morbidity mortality.
Abstract Background Glioma stem-like cells (GSCs) are key drivers of treatment resistance and recurrence in glioblastoma (GBM). Phosphoglycerate dehydrogenase (PHGDH), a crucial enzyme the de novo serine synthesis pathway (SSP), is implicated tumorigenesis therapy across various cancers. However, its specific role GBM, particularly radioresistance, remains poorly understood. Methods In silico analysis GBM patient data assessed SSP enrichment PHGDH expression linked with tumor stemness....
Xiao Chai Hu Decoction originates from Shang Han Lun, and its formulation principle of "harmonizing cold heat" holds significant value in the treatment digestive system diseases. Ancient physicians used "fullness chest ribs" "bitter taste mouth dry throat" as core diagnostic criteria (Shang Ming Li Lun), while modern research has confirmed that this formula can regulate 5-HT transporter (SERT mRNA expression increased by 2.1 times) improve gastrointestinal motility (Wang et al., 2023). There...
Endothelial dysfunction is an early pathological event in diabetic angiopathy which the most common complication of diabetes. This study aims to investigate individual and combined actions Curcumin (Cur) Baicalein (Bai) protecting vascular function. The cellular protective effects Cur, Bai Cur+Bai (1:1, w/w) were tested H2O2 (2.5 mM) impaired EA. hy926 cells. Wistar rats treated with vehicle control as group, Goto-Kakizaki (n=5 each group) (model group), Cur (150 mg/kg), or (75 mg/kg + 75...
To better understand the olfactory receptive mechanisms involved in host selection and courtship behavior of Sitodiplosis mosellana (Diptera: Cecidomyiidae), one most important pests wheat, scanning transmission electron microscopy were used to examine external morphology ultrastructure antennal sensilla. The moniliform antennae exhibit obvious sexual dimorphism: males are markedly longer than those females. Furthermore, each male flagellomere consists two globular nodes, whereas female is...
Introduction: Neuroinflammation is an important pathological event contributing to the onset and progression of neurodegenerative diseases. The hyperactivation microglia triggers release excessive proinflammatory mediators that lead leaky blood-brain barrier impaired neuronal survival. Andrographolide (AN), baicalein (BA) 6-shogaol (6-SG) possess anti-neuroinflammatory properties through diverse mechanisms action. present study aims investigate effects pair-combinations these bioactive...
Neuroinflammation plays an important role in the onset and progression of neurodegenerative diseases. The multicomponent multitarget approach may provide a practical strategy to address complex pathological mechanisms neuroinflammation. This study aimed develop synergistic herbal compound formulas attenuate neuroinflammation using integrated network pharmacology, molecular docking, experimental bioassays. Eight phytochemicals with anti-neuroinflammatory potential were selected present study....