A5049849844- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- DNA Repair Mechanisms
- Epigenetics and DNA Methylation
- Cancer-related molecular mechanisms research
- Lung Cancer Treatments and Mutations
- Cancer Cells and Metastasis
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- COVID-19 Clinical Research Studies
- Ferroptosis and cancer prognosis
- SARS-CoV-2 and COVID-19 Research
- Cytokine Signaling Pathways and Interactions
- Advanced Wireless Communication Technologies
- Cancer Research and Treatments
- Estrogen and related hormone effects
- Extracellular vesicles in disease
- Antenna Design and Analysis
- Phagocytosis and Immune Regulation
- Advanced Antenna and Metasurface Technologies
- RNA Research and Splicing
- Nicotinic Acetylcholine Receptors Study
- Adenosine and Purinergic Signaling
- Cancer, Lipids, and Metabolism
- Hippo pathway signaling and YAP/TAZ
The University of Texas Southwestern Medical Center
2016-2025
Southwestern Medical Center
2009-2024
Southeast University
2023-2024
Harold C. Simmons Comprehensive Cancer Center
2008-2023
The University of Texas MD Anderson Cancer Center
2013
The University of Texas Health Science Center at San Antonio
2012
Sir Run Run Shaw Hospital
2010
University Medical Center
2010
Stanford University
2010
University of South Florida
2010
Abstract Aldehyde dehydrogenase (ALDH) is a candidate marker for lung cancer cells with stem cell-like properties. Immunohistochemical staining of large panel primary non–small cell (NSCLC) samples ALDH1A1, ALDH3A1, and CD133 revealed significant correlation between ALDH1A1 (but not ALDH3A1 or CD133) expression poor prognosis in patients including those stage I N0 disease. Flow cytometric analysis lines patient tumors that most NSCLCs contain subpopulation elevated ALDH activity, this...
SARS-CoV-2 Nsp1 protein binds the mRNA export receptor NXF1-NXT1 to inhibit nuclear of mRNAs and promote infection.
Abstract Mutant KRAS (KM), the most common oncogene in lung cancer (LC), regulates fatty acid (FA) metabolism. However, role of FA LC tumorigenesis is still not sufficiently characterized. Here, we show that KMLC has a specific lipid profile, with high triacylglycerides and phosphatidylcholines (PC). We demonstrate FASN, rate-limiting enzyme synthesis, while being dispensable EGFR-mutant or wild-type LC, required for viability cells. Integrating lipidomic, transcriptomic functional analyses,...
Background Promoter hypermethylation coupled with loss of heterozygosity at the same locus results in gene function many tumor cells. The "rules" governing which genes are methylated during pathogenesis individual cancers, how specific methylation profiles initially established, or what determines type-specific unknown. However, DNA markers that highly and sensitive for common tumors would be useful early detection cancer, those required malignant phenotype identify pathways important as...
Semaphorins SEMA3B and its homologue SEMA3F are 3p21.3 candidate tumor suppressor genes (TSGs), the expression of which is frequently lost in lung cancers. To test TSG candidacy , we transfected them into cancer NCI-H1299 cells, do not express either gene. Colony formation H1299 cells was reduced 90% after transfection with wild-type compared control vector. By contrast, only 30–40% reduction colony seen or variants carrying cancer-associated single amino acid missense mutations. but mutant...
We used CDK4/hTERT-immortalized normal human bronchial epithelial cells (HBEC) from several individuals to study lung cancer pathogenesis by introducing combinations of common oncogenic changes (p53, KRAS, and MYC) followed the stepwise transformation HBECs full malignancy. This model showed that: (i) combination five genetic alterations (CDK4, hTERT, sh-p53, KRAS(V12), c-MYC) is sufficient for tumorigenic conversion HBECs; (ii) genetically identical clones transformed exhibit pronounced...
Although aberrant EGFR signaling is widespread in cancer, inhibition effective only a subset of non–small cell lung cancer (NSCLC) with activating mutations. A majority NSCLCs express wild type (EGFRwt) and do not respond to inhibition. TNF major mediator inflammation-induced cancer. We find that rapid increase level universal adaptive response NSCLC, regardless status. actively suppresses mRNA levels by inducing expression miR-21, resulting decreased stability. Conversely, results loss...
Phosphatidylserine (PS) receptors enhance infection of many enveloped viruses through virion-associated PS binding that is termed apoptotic mimicry. Here we show this broadly shared uptake mechanism utilized by SARS-CoV-2 in cells express low surface levels ACE2. Expression members the TIM (TIM-1 and TIM-4) TAM (AXL) families to cells, facilitate internalization fluorescently-labeled virions increase ACE2-dependent SARS-CoV-2; however, alone did not mediate infection. We were unable detect...
We have positionally cloned and characterized a new calcium channel auxiliary subunit, α<sub>2</sub>δ-2 (<i>CACNA2D2</i>), which shares 56% amino acid identity with the known α<sub>2</sub>δ-1 subunit. The gene maps to critical human tumor suppressor region in chromosome 3p21.3, showing very frequent allele loss occasional homozygous deletions lung, breast, other cancers. tissue distribution of expression is different from α<sub>2</sub>δ-1, mRNA most abundantly expressed lung testis well...
Platelets play a multifaceted role in cancer progression and metastasis. Mean platelet volume (MPV) distribution width (PDW) are commonly used parameters from routine blood test. The aim of the present study was to investigate correlation between indices prognosis patients with non-small cell lung (NSCLC). A total 270 who were diagnosed NSCLC January 2009 December retrospectively analyzed. Patients' characteristics hematologic tests data at initial diagnosis collected. overall survival rate...
Coronavirus disease 2019 is an infectious caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which enters host cells through the cell surface proteins ACE2 and TMPRSS2. Using a variety of normal malignant models tissues from aerodigestive tracts, we investigated expression regulation We find that restricted to select population epithelial cells. Notably, infection with SARS-CoV-2 in cancer lines, bronchial organoids, patient nasal epithelium induces metabolic...
Abstract NPRL2 is one of the novel candidate tumor suppressor genes identified in human chromosome 3p21.3 region. The has shown potent suppression activity vitro and vivo been suggested to be involved DNA mismatch repair, cell cycle checkpoint signaling, regulation apoptotic pathway. In this study, we analyzed endogenous expression protein cellular response cisplatin 40 non–small-cell lung cancer lines found that was significantly reciprocally correlated sensitivity, with a Spearman...
Steroid receptor coactivator-3 (SRC-3) is a histone acetyltransferase and nuclear hormone coactivator, located on 20q12, which amplified in several epithelial cancers well studied breast cancer. However, its possible role lung cancer pathogenesis unknown. We found SRC-3 to be overexpressed 27% of non-small cell (NSCLC) patients (n = 311) by immunohistochemistry, correlated with poor disease-free (P 0.0015) overall 0.0008) survival. Twenty-seven percent NSCLCs exhibited gene amplification, we...
COVID-19 is an infectious disease caused by SARS-CoV-2, which enters host cells via the cell surface proteins ACE2 and TMPRSS2. Using a variety of normal malignant models tissues from aerodigestive respiratory tracts, we investigated expression regulation
Reconfigurable intelligent surface (RIS)-empowered communication, has been considered widely as one of the revolutionary technologies for next generation networks. However, due to novel propagation characteristics RISs, underlying RIS channel modeling and measurement research is still in its infancy not fully investigated. In this paper, we conduct multi-scenario broadband measurements RIS-assisted communications at sub-6 GHz band. The are carried out three scenarios covering outdoor,...
Abstract The tumor suppressor gene RASSF1A regulates cell cycle progression, apoptosis, and microtubule stability is inactivated by promoter methylation in ∼50% of breast cancers. It has been shown previously that the polymorphism A133S reduces its ability to regulate progression this associated with an increased risk cancer. We analyzed frequency 190 Caucasian women without cancer 653 patients including 138 BRCA1 BRCA2 (BRCA1/2) mutation carriers, 395 non–BRCA1/2 mutations 120 untested for...
Nicotine and its derivatives, by binding to nicotinic acetylcholine receptors ( nAChRs) on bronchial epithelial cells, can regulate cellular signaling inflammatory processes. Delineation of nAChR subtypes their responses nicotine stimulation in epithelium may provide information for therapeutic targeting smoking-related inflammation the airway. Expression subunit genes 60 biopsies immunohistochemical staining subcellular locations expression were evaluated. Seven human cell lines (HBECs)...