A5090878287- Phagocytosis and Immune Regulation
- Cancer Mechanisms and Therapy
- Lung Cancer Research Studies
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- Cancer therapeutics and mechanisms
- Renal and related cancers
- RNA modifications and cancer
- Birth, Development, and Health
- Neuroendocrine Tumor Research Advances
- Genetic and Kidney Cyst Diseases
- Salivary Gland Tumors Diagnosis and Treatment
- Pregnancy and preeclampsia studies
- Biochemical and Molecular Research
- Head and Neck Cancer Studies
- Cancer Research and Treatments
- COVID-19 Clinical Research Studies
- Lung Cancer Treatments and Mutations
- Acute Kidney Injury Research
- Radiomics and Machine Learning in Medical Imaging
- Cell death mechanisms and regulation
- COVID-19 and healthcare impacts
- Korean Peninsula Historical and Political Studies
- Microtubule and mitosis dynamics
- Ultrasound and Hyperthermia Applications
University of Pittsburgh
2019-2025
The University of Texas MD Anderson Cancer Center
2020-2024
UPMC Hillman Cancer Center
2023-2024
Children's Hospital of Pittsburgh
2018-2021
University of Pittsburgh Medical Center
2019
Significance Statement Proximal tubular epithelial cells, a primary site of injury in AKI, are rich mitochondria and peroxisomes, the two organelles that mediate fatty acid oxidation. Deletion Sirtuin 5 ( Sirt5 ) reverses posttranslational lysine acylation several enzymes involved The authors demonstrate mice lacking had significantly improved kidney function less tissue damage following either ischemia-induced or cisplatin-induced AKI compared with wild-type mice. These differences...
MYC stimulates both metabolism and protein synthesis, but how cells coordinate these complementary programs is unknown. Previous work reported that, in a subset of small-cell lung cancer (SCLC) cell lines, activates guanosine triphosphate (GTP) synthesis results sensitivity to inhibitors the GTP enzyme inosine monophosphate dehydrogenase (IMPDH). Here, we demonstrated that primary MYChi human SCLC tumors also contained abundant nucleotides. We found elevated SCLCs with acquired...
Coronavirus disease 2019 is an infectious caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which enters host cells through the cell surface proteins ACE2 and TMPRSS2. Using a variety of normal malignant models tissues from aerodigestive tracts, we investigated expression regulation We find that restricted to select population epithelial cells. Notably, infection with SARS-CoV-2 in cancer lines, bronchial organoids, patient nasal epithelium induces metabolic...
In Type 1 Diabetes (T1D), CD4
Abstract AXL, a TAM (TYRO3, and MERTK) family receptor tyrosine kinase, is increasingly being recognized as key determinant of resistance to targeted therapies, well chemotherapy radiation in non–small cell lung cancer (NSCLC) other cancers. We further show here that high levels AXL epithelial-to-mesenchymal transition were frequently expressed subsets both treatment-naïve treatment-relapsed NSCLC. Previously, we others have demonstrated role for mediating DNA damage response (DDR),...
The transcription factor MYC is overexpressed in 30% of small cell lung cancer (SCLC) tumors and known to modulate the balance between two major pathways metabolism: glycolysis mitochondrial respiration. This duality underscores importance further investigation into its role SCLC metabolism could lead insights metabolic targeting approaches.We investigated differences transcriptional metabolomics datasets based on cMYC expression patient line samples. Metabolic pathway utilization was...
COVID-19 is an infectious disease caused by SARS-CoV-2, which enters host cells via the cell surface proteins ACE2 and TMPRSS2. Using a variety of normal malignant models tissues from aerodigestive respiratory tracts, we investigated expression regulation
Lurbinectedin recently received FDA accelerated approval as a second line treatment option for metastatic small cell lung cancer (SCLC). However, there are currently no established biomarkers to predict SCLC sensitivity or resistance lurbinectedin preclinical studies guide rational combinations.Drug was assayed in proliferation assays and xenograft models. Baseline proteomic profiling performed by reverse-phase protein array. Lurbinectedin-induced changes intracellular signaling pathways...
Delta-like Ligand 3 (DLL3) targeting therapies are promising in small cell lung cancer (SCLC) treatment. However, DLL3 expression SCLC and other neuroendocrine neoplasms (NEN) is heterogeneous not well characterized. We describe the landscape of at mRNA protein levels across SCLC, large carcinoma (LCNEC), non-small cancer. Additionally, we explore its extra-pulmonary NEN (EP-NEN) using a standardized IHC assay. enriched LCNEC along with combined histology cancers. Moreover, find wide range...
Abstract Non-small cell lung cancer (NSCLC) has the highest incidence of brain metastases (BM), with ∼40% patients developing BM. We identified a significant enrichment MET amplification (amp) in NSCLC BM compared to primary and liver metastases. MET, receptor tyrosine kinase, its ligand, hepatocyte growth factor (HGF), promote proliferation, epithelial-mesenchymal transition, angiogenesis, metastasis metabolic reprogramming through glycolysis. have found that amp altered cells increased...
Nephron progenitors, the cell population that give rise to functional unit of kidney, are metabolically active and self-renew under glycolytic conditions. A switch from glycolysis mitochondrial respiration drives these cells toward differentiation, but mechanisms control this poorly defined. Studies have demonstrated kidney formation is highly dependent on oxygen concentration, which largely regulated by von Hippel-Lindau (VHL; a protein component ubiquitin ligase complex) hypoxia-inducible...
Prenatal hypoxia is a gestational stressor that can result in developmental abnormalities or physiological reprogramming, and often decreases cellular capacity against secondary stress. When developing fetus exposed to hypoxia, blood flow preferentially redirected vital organs including the brain heart over other kidney. Hypoxia-induced injury lead structural malformations kidney; however, even absence of lesions, physiologically reprogram kidney leading decreased function increased...
Low nephron number results in an increased risk of developing hypertension and chronic kidney disease. Intrauterine growth restriction is associated with a deficit humans, commonly caused by placental insufficiency, which fetal hypoxia. The underlying mechanisms hypoxia impacts development are poorly understood. microRNA-210 the most consistently induced microRNA known to promote cell survival hypoxic environment. In this study, role was evaluated using global knockout mouse. A male-specific...
Abstract Non-small cell lung cancer (NSCLC) is the most common primary tumor to metastasize brain, with up 40% of NSCLC patients developing brain metastases (BM). These BM portend a poor prognosis, even when extracranial disease well-controlled. While targeted therapy and immunotherapy have improved survival, there are no therapies specifically targeting BM. Our lab identified significant enrichment MET amplification in adenocarcinoma (LUAD) (16%) compared (3%) liver (5%). MET, receptor...
e23034 Background: Since 2019, the Centers for Medicare & Medicaid Services (CMS) has required hospitals to publish gross charges all goods and services provided. In 2021, CMS amended this requirement include publishing standard charge files, which cash payer-negotiated prices This was enacted in an attempt reduce healthcare by reducing information asymmetry generating competition among both insurers hospitals. complex proton therapy is one of most expensive modalities cancer treatment,...
e23039 Background: Proton therapy is one of the most expensive treatment modalities offered to cancer patients, and only 44 proton centers are operational in U.S. Of those, 5 Medicare Prospective Payment System (PPS)-exempt reimbursed based on their reported costs rather than predetermined prices. These PPS-exempt set adjusted payment rates reflect expense required for providing specialized care. We hypothesized that would have higher complex delivery compared non-exempt centers. Methods:...