A5100459268- X-ray Diffraction in Crystallography
- Crystallization and Solubility Studies
- Crystal Structures and Properties
- Nanoparticle-Based Drug Delivery
- Cancer Cells and Metastasis
- Nonlinear Optical Materials Research
- High-pressure geophysics and materials
- HER2/EGFR in Cancer Research
- RNA Interference and Gene Delivery
- Magnesium Alloys: Properties and Applications
- Cancer Genomics and Diagnostics
- Nanoplatforms for cancer theranostics
- Cancer Immunotherapy and Biomarkers
- Aluminum Alloys Composites Properties
- Chalcogenide Semiconductor Thin Films
- Advanced Drug Delivery Systems
- Cancer-related Molecular Pathways
- Peptidase Inhibition and Analysis
- Graphene and Nanomaterials Applications
- Breast Cancer Treatment Studies
- Nanocomposite Films for Food Packaging
- Organometallic Compounds Synthesis and Characterization
- Bioactive Compounds and Antitumor Agents
- Color Science and Applications
- Iron-based superconductors research
Hebei Medical University
2009-2025
Fourth Hospital of Hebei Medical University
2021-2025
Qilu University of Technology
2025
Hubei University of Science and Technology
2024
Chinese Academy of Sciences
2020-2024
Chinese Academy of Agricultural Sciences
2024
Ministry of Agriculture and Rural Affairs
2024
Feed Research Institute
2024
University of Chinese Academy of Sciences
2020-2024
Technical Institute of Physics and Chemistry
2020-2024
With the rapid advancement of genetic and protein engineering, proteins peptides have emerged as promising drug molecules for therapeutic applications. Consequently, there has been a growing interest in field chemical modification technology to address challenges associated with their clinical use, including clearance from circulation, immunogenicity, physical instabilities (such aggregation, adsorption, deamination, clipping, oxidation, etc.), enzymatic degradation. Polyethylene glycol...
Ternary blend films were prepared with different ratios of starch/polyvinyl alcohol (PVA)/citric acid. The characterized by field emission scanning electron microscopy (FE-SEM), thermogravimetric analysis, as well Fourier transform infrared (FTIR) analysis. influence acid and drying times on the performance properties, transparency, tensile strength (TS), water vapor permeability (WVP), solubility (WS), color difference (ΔE), antimicrobial activity ternary blends investigated. alcohol/citric...
Abstract Background Epithelial–mesenchymal transition (EMT) is implicated in the metastatic process and presents a challenge to epithelial cell adhesion molecule‐based detection of circulating tumor cells (CTCs), which have been demonstrated be prognostic indicator breast cancer. Although evidence has indicated that heterogeneity CTCs based on EMT markers associated with disease progression, no standard recommendations established for clinical practice. This study aimed evaluate significance...
Abstract Poor delivery of insoluble anticancer drugs has so far precluded their clinical application. In this study, an efficient tumor targeted-nanoparticle system, transferrin-eight-arm-polyethylene glycol–dihydroartemisinin nanoparticles (TF-8arm-PEG-DHA NPs) for the vehiculation dihydroartemisinin (DHA) was first prepared and evaluated its targeting efficiency cytotoxicity in vitro vivo to Lewis lung carcinoma (LLC) cells, which overexpress transferrin receptors (TFRs). The synthesized...
Abstract A series of nonlinear optical (NLO) chalcohalides AXHg 3 P 2 S 8 (A = Rb, Cs; X Cl, Br), which contain various Hg‐based building units including mixed‐anion trigonal planar [HgS X] 3− and tetrahedral 5− , are successfully synthesized. These compounds display good water resistance, wide infrared transparent region (0.42–17 µ m), high laser‐induced damage thresholds (4.5–6 × AgGaS ), strong phase‐matchable second harmonic generation (SHG) response close to . The chalcohalide groups...
In this study, a targeted nanoparticle platform for co-delivery of anticancer drugs based on folate-conjugated eight-arm-polyethylene glycol-betulinic acid (F-8arm-PEG-BA) was first presented. F-8arm-PEG-BA synthesized by introducing target molecules (folate) and drug (betulinic acid, BA) to hydrophilic (8arm-PEG). Then another drug, hydroxycamptothecin (HCPT), encapsulated into the self-assembled nanoparticles from conjugate simple nanoprecipitation method. These F-8arm-PEG-BA/HCPT (NPs)...
Human epidermal growth factor receptor 2 (HER2) protein overexpression or gene amplification is an important predictive biomarker for identifying patients with breast cancer, who may benefit from HER2-targeted therapy. However, little known about the molecular landscape and efficacy of therapy in HER2-mutated metastatic cancer. We analysed HER2 mutation features 1184 invasive In addition, a single-arm, prospective, phase-II study (NCT03412383) pyrotinib was conducted patient...
Random fiber lasers (RFLs) can generate flexible near-infrared lasing wavelengths with high power/high efficiency in simple configurations, which could be excellent candidates to realize low spatial and/or temporal coherence mid-infrared (MIR) random via the difference-frequency generation (DFG) process. Here, we explore feasibility, and demonstrate proof of concept MIR continuous-wave (CW) through DFG RFLs a new promising nonlinear optical crystal BaGa <sub...
Chalcogenides are promising candidates for exploring mid- and far-infrared nonlinear optical (NLO) materials. Nevertheless, although tellurides possess greater advantages in the above-mentioned spectral regions, reports on telluride NLO materials far fewer than those sulfides selenides. In this work, a new quaternary NLO-active telluride, KCd4Ga5Te12, was discovered, its Rb Cs analogues were successfully synthesized. They crystallized trigonal R3 space group structure features 3D...
Metal chalcogenides play a critical role in the infrared (IR) nonlinear optical (NLO) field. However, Eu-based chalcogenide-type IR NLO materials are still scarce up to now. In this paper, two new quaternary chalcogenides, EuHgGeSe4 and EuHgSnS4, containing "NLO active groups" [HgQ4]6– (Q = S, Se) [GeSe4]4–/[SnS4]4– were synthesized through traditional high-temperature solid-state reactions. They possess noncentrosymmetric structures, crystallizing Ama2 space group, exhibit strong...
Tumour-associated macrophages (TAMs) play an important role in the growth, progression, and metastasis of tumours. Epithelial-mesenchymal transition (EMT) is a mechanism for tumour invasion metastasis. In this study, we aimed to determine whether TAMs can induce EMT Kazakh oesophageal squamous cell cancer (ESCC).CD163 was used as marker TAMs, density nest surrounding stroma quantified using immunohistochemistry (IHC). IHC staining evaluate expression E-cadherin (epithelial marker) vimentin...
A new protein–hydrophobic polymeric nanoparticle platform BSA–PLLA NPs has been prepared. large amount of BA was well encapsulated into the NPs. Moreover, BSA–PLLA/BA shows excellent antitumor activity.
To face the growing demand of polymeric nanoparticles with biocompatibility and a drug release profile, in this work, novel carboxymethylcellulose-based pH redox dual-responsive nanoparticle, carboxymethyl cellulose-dithiopropionate hydrazide-8arm-polyethylene glycol-pterostilbene/10-hydroxy camptothecin (CTPP/HCPT), was prepared for efficient codelivery. These well-dispersed CTPP/HCPT NPs were dimension around 144 nm exhibited high binary loading capacity good biocompatibility. The biggest...