A5029963577- 3D Printing in Biomedical Research
- Electrospun Nanofibers in Biomedical Applications
- Advanced Sensor and Energy Harvesting Materials
- Neuroscience and Neural Engineering
- Cellular Mechanics and Interactions
- Bone Tissue Engineering Materials
- Carbon and Quantum Dots Applications
- Nanoplatforms for cancer theranostics
- Nerve injury and regeneration
- Corrosion Behavior and Inhibition
- Photoreceptor and optogenetics research
- Hydrogels: synthesis, properties, applications
- Conducting polymers and applications
- Silk-based biomaterials and applications
- Hydrogen embrittlement and corrosion behaviors in metals
- Tissue Engineering and Regenerative Medicine
- Concrete Corrosion and Durability
- EEG and Brain-Computer Interfaces
- Lipid metabolism and biosynthesis
- Photosynthetic Processes and Mechanisms
- Luminescence and Fluorescent Materials
- Planarian Biology and Electrostimulation
- Advanced Materials and Mechanics
- Cancer-related molecular mechanisms research
- Additive Manufacturing and 3D Printing Technologies
Sichuan University
2016-2025
Xijing Hospital
2025
Air Force Medical University
2025
Shaanxi Institute of International Trade & Commerce
2024
Shaanxi University of Chinese Medicine
2024
Guangxi Medical University
2021
University of Glasgow
2021
Dalian University of Technology
2021
University of Science and Technology
2021
Chengdu University
2015-2020
Abstract Electrical stimulation is regarded pivotal to promote repair of nerve injuries, however, failed get extensive application in vivo due the challenges noninvasive electrical loading accompanying with construction biomimetic cell niche. Herein, a new concept magneto responsive electric 3D matrix for remote and wireless demonstrated. By preparation magnetoelectric core/shell structured Fe 3 O 4 @BaTiO NPs‐loaded hyaluronan/collagen hydrogels, which recapitulate considerable...
Modular tissue engineering holds great potential in regenerating natural complex tissues by three-dimensional modular scaffolds with predefined geometry and biological characters. In tissue-like construction, a scaffold an appropriate mechanical rigidity for assembling fabrication high biocompatibility cell survival is the key to successful bioconstruction. this work, series of composite hydrogels (GH0, GH1, GH2, GH3) based on combination methacrylated gelatin (GelMA) hydroxyapatite (HA) was...
Following spinal cord injury (SCI), the transmission of electrical signals is interrupted, and an oxidative microenvironment generated, hindering nerve regeneration functional recovery. The strategies regulating pathological while restoring endogenous signal hold promise for SCI treatment. However, challenges are still faced in simply fabricating bioactive scaffolds with both antioxidation conductivity. Herein, aiming to construct antioxidative conductive regeneration, difunctional...
A hydrogel that fuses long-term biologic integration, multimodal responsiveness, and therapeutic functions has received increasing interest as a wearable implantable sensor but still faces great challenges an all-in-one by itself. Multiple bonding with stimuli response in biocompatible lights up the field of soft interfaces suitable for both applications. Given that, we proposed strategy combining chemical cross-linking stimuli-responsive physical interactions to construct multifunctional...
Mitochondria play significant roles in maintaining a stable internal environment for cell metabolism. Hence, real-time monitoring of the dynamics mitochondria is essential further understanding mitochondria-related diseases. Fluorescent probes provide powerful tools visualizing dynamic processes. However, most mitochondria-targeted are derived from organic molecules with poor photostability, making long-term challenging. Herein, we design novel probe based on carbon dots high performance...
The shortage of donors is a major challenge for transplantation; however, organs from genetically modified pigs can serve as ideal supplements1,2. Until now, porcine hearts and kidneys have been successively transplanted into humans3–7. In this study, heterotopic auxiliary transplantation was used to donate six-gene-edited pig liver brain-dead recipient. graft function, haemodynamics, immune inflammatory responses the recipient were monitored over subsequent 10 days. Two hours after portal...
Abstract Bacterial infections and tumor tissues are characterized by complex microenvironments with uneven oxygen availability. Effective photodynamic therapy for these conditions requires photosensitizers that can perform optimally within such environments, specifically generating both type I II reactive species (ROS) simultaneously. Carbon dots (CDs), a of fluorescent nanomaterial smaller than 10 nm, commonly used to treat bacterial tumors. However, their current limitations, as short...
Engineering three-dimensional (3D) scaffolds with in vivo like architecture and function has shown great potential for tissue regeneration. Here we developed a facile microfluidic-based strategy the continuous fabrication of cell-laden microfibers hierarchically organized architecture. We show that photolithographically fabricated microfluidic devices offer simple reliable way to create anatomically inspired complex structures. Furthermore, use photo-cross-linkable methacrylated alginate...
Inflexible hydrophilic AlgMA was introduced into a bioactive GelMA hydrogel to enhance stiffness and hydrophilicity, thus improving surface tension driven assembly of modular constructs with spatial organized cell distribution biofunctions.
Bioactive metal-organic frameworks (bio-MOFs) built from biofunctional metal ions and linkers show a new strategy to construct multifunctional theranostic platforms. Herein, bio-MOF is synthetized via the self-assembling of Fe3+ doxorubicin hydrochloride (DOX) molecules. Then, through stepwise assembly strategy, another bio-MOFs structure consisting Gd3+ 1,3,5-benzenetricarboxylic acid (H3 BTC) wrapped on surfaces Fe-DOX nanoparticles, followed by adsorbing photosensitizer indocyanine green...
A bio-based hydrogel is constructed as an adaptive, biocompatible, and conductive neural interface. The advances generating tight mechanical coupling, low impedance, high charge storage capacity resulted in efficient signal recording.
Photoresponsive supramolecular hydrogels based on the host–guest interaction between cyclodextrin (CD) and azobenzene (Azo) are highly favored in "on-demand" biological applications. Nevertheless, most Azo/CD-based UV-responsive, exhibiting poor tissue penetrability potential cytotoxicity; more importantly, complete gel–sol transition under irradiation makes intelligent systems unstable. Here, we report a red-light-responsive semiconvertible hydrogel tetra-ortho-methoxy-substituted Azo...
Delivering electrical signals to neural cells and tissue has attracted increasing attention in the treatment of nerve injuries. Unlike traditional wired stimulation, wireless remote light stimulation provides less invasive longer-lasting interfaces, holding great promise injuries neurodegenerative diseases, as well human-computer interaction. Additionally, a bioactive matrix that bridges injured gap induces regeneration is essential for repair. However, it still challenging construct 3D...
Electrical deep brain stimulation (DBS) is a top priority for pharmacoresistant epilepsy treatment, while less-invasive wireless DBS an urgent but challenging. Herein, we developed conceptual platform to realize local electric via 1D-structured magnetoelectric Fe3O4@BaTiO3 nanochains (FBC). The FBC was facilely synthesized magnetic-assisted interface coassembly, possessing higher electrical output by inducing larger strain from the anisotropic structure and coherence. Subsequently,...
Type II collagen is a prospective chondro-inductive matrix for bone marrow mesenchymal stem cells (BMSCs), key component of the extracellular cartilage; however, its application limited by deficient fibrillogenesis and gelation. Herein, type methacrylamide (Col-II-MA) was synthesized an amidation reaction between ε-amino groups on lysine methacrylic anhydride to enable photo-crosslinking collagen, thus accomplishing one-step preparation mono-component hydrogel first time. BMSCs encapsulated...
Traditional tumor treatments suffer from severe side effects on account of their invasive process and inefficient outcomes. Featuring a unique physical microenvironment, the microenvironment (TME) provides new research direction for designing more efficient safer treatment paradigms. In this study, we fabricated polydopamine (PDA)-based TME-responsive nanosystem, which successfully integrates glucose degradation, Fenton reaction, photothermal therapy cancer therapy. Through convenient...
Spontaneous recovery after spinal cord injury (SCI) is extremely limited since the severe inflammatory responses lead to secondary damage, and diseased extracellular matrix (ECM) fails provide inductive cues for nerve regeneration. To address these dilemmas, herein, we propose a biomaterial-based strategy combining neuroprotection neuroinduction SCI repair. Taking advantage of microfluidic chip, constructed imine-crosslinked aldehyde-methacrylate-hyaluronan/collagen hybrid hydrogel...