A5023718426- Advanced X-ray and CT Imaging
- 3D Printing in Biomedical Research
- Circadian rhythm and melatonin
- Electrospun Nanofibers in Biomedical Applications
- Nanoplatforms for cancer theranostics
- Cellular Mechanics and Interactions
- Bone Tissue Engineering Materials
- Transportation Planning and Optimization
- Plant-based Medicinal Research
- Advanced Sensor and Energy Harvesting Materials
- Nerve injury and regeneration
- Cancer Genomics and Diagnostics
- Nanoparticle-Based Drug Delivery
- Neutrino Physics Research
- Medical Imaging Techniques and Applications
- Genetic factors in colorectal cancer
- Traffic Prediction and Management Techniques
- COVID-19 Clinical Research Studies
- Genetics, Aging, and Longevity in Model Organisms
- Bioactive Natural Diterpenoids Research
- Particle physics theoretical and experimental studies
- Advanced battery technologies research
- Graphene and Nanomaterials Applications
- Long-Term Effects of COVID-19
- Traffic control and management
University of Chinese Academy of Sciences
2021-2025
Kunming Institute of Botany
2021-2025
Chinese Academy of Sciences
2021-2025
Johns Hopkins Medicine
2021-2025
Zhengzhou University
2024-2025
Johns Hopkins University
2020-2025
Johns Hopkins Hospital
2025
Institute of Organic Chemistry with Centre of Phytochemistry
2025
South China University of Technology
2025
Sichuan University
2016-2024
Abstract Electrical stimulation is regarded pivotal to promote repair of nerve injuries, however, failed get extensive application in vivo due the challenges noninvasive electrical loading accompanying with construction biomimetic cell niche. Herein, a new concept magneto responsive electric 3D matrix for remote and wireless demonstrated. By preparation magnetoelectric core/shell structured Fe 3 O 4 @BaTiO NPs‐loaded hyaluronan/collagen hydrogels, which recapitulate considerable...
Since their original description as a distinctive neoplastic entity, ~50 TFE3 -rearranged perivascular epithelioid cell tumors (PEComas) have been reported. We herein report 25 new PEComas and review the published literature to further investigate clinicopathologic spectrum. Notably, 5 of cases were associated with prior history chemotherapy treatment for cancer. This is in keeping reports, based mainly on small case series, overall 11% being diagnosed postchemotherapy. The median age our...
A medical nanoplatform with small size, low cost, biocompatibility, good biodegradability, and, in particular, multifunctionality has attracted much attention the exploration of novel therapeutic methodologies. As an emerging material self-assembled porous structure, metal–organic frameworks (MOFs) have high expectations because their special properties compared to traditional materials. Therefore, integration MOFs and functional materials is leading creation new multifunctional...
Natural nerve tissue is composed of bundles with multiple aligned assembles, and matrix electroconductivity beneficial to the transmission intercellular electrical signals, or effectively deliver external cues cells. Herein, aiming at biomimetic design extracellular for neurons, we first synthesized electroconductive polypyrrole (PPy) nanoparticles modified hydrophilicity improve their uniformity in collagen hydrogel. Next, cell-laden collagen-PPy hybrid hydrogel microfibers highly oriented...
Hydroxyapatite nanoparticles (HA NPs) have been acknowledged for their benign biocompatibility and proliferation inhibition effect on tumor cells, attracting considerable attention therapeutics without late effects. However, unnoticeable cytotoxicity of HA NPs limited the final clinical therapeutic efficacy. Herein, a two-phase synthetic approach was developed to synthesize sphere-like by varying conventional growth habit precipitate. We present our in vitro vivo experimental evidence that...
Following spinal cord injury (SCI), the transmission of electrical signals is interrupted, and an oxidative microenvironment generated, hindering nerve regeneration functional recovery. The strategies regulating pathological while restoring endogenous signal hold promise for SCI treatment. However, challenges are still faced in simply fabricating bioactive scaffolds with both antioxidation conductivity. Herein, aiming to construct antioxidative conductive regeneration, difunctional...
Bioactive metal-organic frameworks (bio-MOFs) built from biofunctional metal ions and linkers show a new strategy to construct multifunctional theranostic platforms. Herein, bio-MOF is synthetized via the self-assembling of Fe3+ doxorubicin hydrochloride (DOX) molecules. Then, through stepwise assembly strategy, another bio-MOFs structure consisting Gd3+ 1,3,5-benzenetricarboxylic acid (H3 BTC) wrapped on surfaces Fe-DOX nanoparticles, followed by adsorbing photosensitizer indocyanine green...
Treatments for coronavirus disease 2019 (COVID-19) are limited by suboptimal efficacy. From January 30, 2020 to March 23, 2020, we conducted a non-randomised controlled trial, in which all adult patients with laboratory-confirmed COVID-19 were assigned three groups non-randomly and given supportive treatments: Group A, Lopinavir-Ritonavir; B, Huashi Baidu Formula (a Chinese medicineformula made the China Academy of Medical Sciences treat COVID-19, is now clinical trial period) C, Formula....
Based on widely used photoacoustic imaging (PAI) and photothermal properties of polydopamine (PDA), a multifunctional Gd-PDA-Ce6@Gd-MOF (GPCG) nanosystem with core-shell structure strong ability was constructed. Benefitting from the metal-organic framework (MOF) structure, GPCG nanoparticles (NPs) showed enhanced magnetic resonance (MRI) high relaxation rates (r1 = 13.72 mM-1 s-1 r2 216.14 s-1). The MRI effect Gd ions combined PAI PDA, giving NPs dual-modal ability. core, mainly composed PDA...
Photoresponsive supramolecular hydrogels based on the host–guest interaction between cyclodextrin (CD) and azobenzene (Azo) are highly favored in "on-demand" biological applications. Nevertheless, most Azo/CD-based UV-responsive, exhibiting poor tissue penetrability potential cytotoxicity; more importantly, complete gel–sol transition under irradiation makes intelligent systems unstable. Here, we report a red-light-responsive semiconvertible hydrogel tetra-ortho-methoxy-substituted Azo...
With the aging population of society, incidence rate osteoporosis is increasing year by year. Early diagnosis plays a significant role in progress disease prevention. As newly developed technology, computed tomography (CT) radiomics could discover radiomic features difficult to recognize visually, providing convenient, comprehensive and accurate diagnosis. This study aimed develop validate clinical-radiomics model based on monochromatic imaging single source dual-energy CT for prediction.One...
The mammalian chitinase family includes members both with and without enzymatic activity against chitin, a product of fungal cell walls, exoskeletons crustaceans insects, the microfilarial sheaths parasitic nematodes. Two that family, Ym1 acidic (AMCase), are strongly upregulated in pulmonary T helper (Th) 2 inflammation but not Th1 inflammation. sites expression these products incompletely known. We show here that, two different models Th2 inflammation, AMCase mutually exclusively expressed...
In Brief OBJECTIVE: To estimate whether tissue DNA genotyping is effective for the confirmation and subclassification of hydatidiform moles. METHODS: Consecutive cases products conception were selected based on histologic alterations that are suspicious molar pregnancy. was performed by a multiplex polymerase chain reaction targeting 15 tetrameric polymorphic loci human genome. RESULTS: A total 205 included. informative in all, leading to final identification 60 moles, including 17 complete...
Traditional tumor treatments suffer from severe side effects on account of their invasive process and inefficient outcomes. Featuring a unique physical microenvironment, the microenvironment (TME) provides new research direction for designing more efficient safer treatment paradigms. In this study, we fabricated polydopamine (PDA)-based TME-responsive nanosystem, which successfully integrates glucose degradation, Fenton reaction, photothermal therapy cancer therapy. Through convenient...
Cell senescence is one of the most important processes determining cell fate and involved in many pathophysiological conditions, including cancer, neurodegenerative diseases, other aging-associated diseases. It has recently been discovered that E3 ubiquitin ligase STIP1 homology U-box–containing protein 1 (STUB1 or CHIP) up-regulated during human fibroblasts modulates senescence. However, molecular mechanism underlying STUB1-controlled not clear. Here, using affinity purification MS-based...
Delivering electrical signals to neural cells and tissue has attracted increasing attention in the treatment of nerve injuries. Unlike traditional wired stimulation, wireless remote light stimulation provides less invasive longer-lasting interfaces, holding great promise injuries neurodegenerative diseases, as well human-computer interaction. Additionally, a bioactive matrix that bridges injured gap induces regeneration is essential for repair. However, it still challenging construct 3D...
Spontaneous recovery after spinal cord injury (SCI) is extremely limited since the severe inflammatory responses lead to secondary damage, and diseased extracellular matrix (ECM) fails provide inductive cues for nerve regeneration. To address these dilemmas, herein, we propose a biomaterial-based strategy combining neuroprotection neuroinduction SCI repair. Taking advantage of microfluidic chip, constructed imine-crosslinked aldehyde-methacrylate-hyaluronan/collagen hybrid hydrogel...