A5100609676- Viral Infections and Immunology Research
- Animal Disease Management and Epidemiology
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Viral gastroenteritis research and epidemiology
- Pancreatitis Pathology and Treatment
- RNA and protein synthesis mechanisms
- Long-Term Effects of COVID-19
- Animal Virus Infections Studies
- Pancreatic and Hepatic Oncology Research
- Nutrition and Health in Aging
- Inflammatory Biomarkers in Disease Prognosis
- Body Composition Measurement Techniques
- Cancer Mechanisms and Therapy
- Immunotherapy and Immune Responses
- Herpesvirus Infections and Treatments
- Cancer-related molecular mechanisms research
- Traditional Chinese Medicine Studies
- Diet and metabolism studies
- Virus-based gene therapy research
- Histone Deacetylase Inhibitors Research
- Hair Growth and Disorders
- Oral Health Pathology and Treatment
- Ovarian cancer diagnosis and treatment
- Dermatologic Treatments and Research
Wuhan Institute of Bioengineering
2020-2025
Daping Hospital
2016-2025
Army Medical University
2016-2025
Chongqing Municipal Health Commission
2025
Shanghai East Hospital
2023-2024
The University of Texas MD Anderson Cancer Center
2018-2024
National Clinical Research Center for Digestive Diseases
2023
First Affiliated Hospital Zhejiang University
2023
State Key Laboratory of Diagnosis and Treatment of Infectious Diseases
2020-2023
Ningbo First Hospital
2023
Recent studies have demonstrated the prognostic value of C-reactive protein/albumin (CRP/Alb) ratio in cancer. However, role CRP/Alb advanced pancreatic cancer (PC) has not been examined. A retrospective study 233 patients with PC was conducted. We investigated relationship between ratio, clinicopathological variables, and overall survival (OS). The optimal cutoff point 0.54. higher significantly associated an elevated neutrophil-lymphocyte (NLR) (P < 0.001) modified Glasgow score (mGPS)...
Despite the ongoing spread of coronavirus disease 2019 (COVID-19), knowledge about factors affecting prolonged viral excretion is limited.In this study, we retrospectively collected data from 99 hospitalized patients with (COVID-19) between 19 January and 17 February 2020 in Zhejiang Province, China. We classified them into 2 groups based on whether virus test results eventually became negative. Cox proportional hazards regression was used to evaluate associated severe acute respiratory...
(1) Background: Transient receptor potential vanilloid 3 (TRPV3) is a member of the TRP channels family Ca2+-permeant channels. The proteins some are highly expressed in cancer cells. This study aimed to assess clinical significance and biological functions TRPV3 non-small cell lung (NSCLC); (2) Methods: Immunohistochemistry was used detect expression NSCLC tissues adjacent noncancerous tissues. Western blot protein expressions TRPV3, CaMKII, p-CaMKII, CyclinA, CyclinD, CyclinE1, CDK2, CDK4,...
Treatments for coronavirus disease 2019 (COVID-19) are limited by suboptimal efficacy. From January 30, 2020 to March 23, 2020, we conducted a non-randomised controlled trial, in which all adult patients with laboratory-confirmed COVID-19 were assigned three groups non-randomly and given supportive treatments: Group A, Lopinavir-Ritonavir; B, Huashi Baidu Formula (a Chinese medicineformula made the China Academy of Medical Sciences treat COVID-19, is now clinical trial period) C, Formula....
Abstract Background Multiple antigens, autoantibodies (AAb), and antigen-autoantibody (Ag-AAb) complexes were compared for their ability to complement CA125 early detection of ovarian cancer. Methods Twenty six biomarkers measured in a single panel sera from women with stage (I-II) cancers ( n = 64), late (III-IV) (186), benign pelvic masses (200) healthy controls (502), then split randomly (50:50) into training set identify the most promising classifier validation compare its performance...
Abstract Breast cancer is one of the most threatening diseases for women. Long noncoding RNAs were reported to be involved in breast development. In this study, we analyzed The Cancer Genome Atlas tissue high‐throughput sequencing data and screened validated low‐expressing long RNA named MAGI2‐AS3. Through gene coexpression analysis, found that MAGI2‐AS3 has a good expression correlation with MAGI2. Overexpression or MAGI2 cells MCF‐7 would inhibit Wnt/β‐catenin pathway cell proliferation...
Advanced gastric cancer has a poor prognosis because of advanced is prone to metastasis. It urgent for us find an indicator predict the in timely fashion. Research revealed that inflammation important role predicting survival some cancers. The purpose this study was evaluate significance neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte (PLR) on metastatic (GC).This retrospective review 110 patients were at presentation diagnosed with stage IV GC all received palliative...
Abstract Farnesoid X receptor (FXR, encoded by NR1H4), a bile acid‐activated nuclear receptor, is widely implicated in human tumorigenesis. The FXR agonist obeticholic acid (OCA) has preliminarily displayed tumour suppressor potential. However, the anticancer effects of this agent on colorectal cancer (CRC) remain unclear. In study, treatment colon cells with OCA inhibited cell proliferation and invasion vitro, retarded growth vivo prevented G 0 /G 1 to S phase transition. Moreover,...
Mounting evidence has linked both obesity and metabolic disorders with dysbiosis of the gut microbiota. Dietary inulin is conducive to modulating this dysbiosis, represents a potential means improve glucose lipid metabolism. However, mechanisms underlying these improvements are largely unclear. Obese ob/ob mice were fed standard chow, low fiber diet (LFD) or high (HFD) for 4 weeks, body weight, fecal short chain fatty acids (SCFAs) level, plasma liver profiles analyzed. Oral tolerance...
Background: Previous research suggested that Chinese Medicine (CM) Formula Huashibaidu granule might shorten the disease course in coronavirus 2019 (COVID-19) patients. This aimed to investigate early treatment effect of well-managed patients with mild COVID-19. Methods: An unblinded cluster-randomized clinical trial was conducted at Dongxihu FangCang hospital. Two cabins were randomly allocated a CM or control group, 204 COVID-19 participants each cabin. All received conventional over 7 day...
Lung cancer metastasis to major organs is an important factor affecting survival. We analyzed the influence of patient characteristics on incidence and survival organs.We collected data from Surveillance, Epidemiology, End Results database 58 659 patients diagnosed with stage IV primary lung cancer, including age, sex, race, histological type tumor, laterality, site, number extrametastatic sites, treatment.Multiple variables affected According following were more common: bone adenocarcinoma;...
Butyrate, a short-chain fatty acid (SCFA), has demonstrated significant efficacy in preventing colitis-associated inflammation. Acute pancreatitis is an acute gastrointestinal disorder characterized by increased systemic inflammation, bacterial translocation, and disrupted intestinal barrier. However, the effects mechanisms of butyrate attenuating remain unclear. In this study, we established two mouse models induced cerulein (Cer) taurocholate (TA), which were further exacerbated ketogenic...
Background: The three commercial Enterovirus 71 (EV71) inactivated vaccines which have effectively controlled the EV71 pandemic currently rely on inherent variable in vivo potency methods for batch release. To align with 3R (Replacement, Reduction, Refinement) principles and enhance quality control, this study referred to WHO guidelines European Pharmacopoeia develop vitro relative (IVRP) methods. Methods: Working standards tracing phase 3 clinical were established. Manufacture-specific IVRP...
In the face of COVID-19 pandemic caused by newly emerged SARS-CoV-2, an inactivated, Vero cell-based, whole virion vaccine candidate has been developed and entered into phase III clinical trials within six months. Biochemical immunogenic characterization structural proteins their post-translational modifications in virions, end-products candidate, would be essential for quality control process development products studying immunogenicity pathogenesis SARS-CoV-2. By using a panel rabbit...
Coxsackievirus A6 (CV-A6) has been emerging as a major pathogen of hand, foot and mouth disease (HFMD). Study on the pathogenesis CV-A6 infection development vaccines is hindered by lack appropriate animal models. Here, we report an actively immunized-challenged mouse model to evaluate efficacy Vero-cell-based, inactivated vaccine candidate. The neonatal Kunming mice were inoculated with purified, formaldehyde-inactivated days 3 9, followed challenging day 14 naturally selected virulent...
Hand, foot and mouth disease (HFMD) is caused by a variety of serotypes in species A the Enterovirus genus, including recently re-emerged Coxsackievirus A2 (CV-A2), CV-A4 CV-A5. For development diagnostic reagents, for surveillance, multivalent vaccines against HFMD, antigenicity HFMD-associated enteroviruses warrants investigation. The purified virions were inoculated into Balb/c mice hybridomas obtained secreting monoclonal antibodies (mAbs) directed cross-reacting with other closely...
Abstract Background Concentrated growth factor (CGF) injection has proven effective in treating androgenetic alopecia (AGA). The primary mechanism of CGF AGA is thought to be the CD34+ stem cells and platelets‐associated factors being injected into scalp. efficacy may rely on activation level these platelets. 640 nm laser a United States Food Drug Administration approved treatment that activates follicle cells. Therefore, we hypothesize pretreating with further activate platelets, thereby...
The enterovirus A71 (EV71) inactivated vaccine is an effective intervention to control the spread of virus and prevent EV71-associated hand, foot, mouth disease (HFMD). It widely administered infants children in China. empty particles (EPs) full (FPs) generated during production have different antigenic immunogenic properties. However, antigen detection methods currently used were established without considering differences antigenicity between EPs FPs. There also a lack other analytical for...