A5100722760- Intracerebral and Subarachnoid Hemorrhage Research
- Acute Ischemic Stroke Management
- Cancer, Hypoxia, and Metabolism
- Antiplatelet Therapy and Cardiovascular Diseases
- RNA modifications and cancer
- Renal cell carcinoma treatment
- Hepatocellular Carcinoma Treatment and Prognosis
- Colorectal Cancer Treatments and Studies
- Viral gastroenteritis research and epidemiology
- Cancer Genomics and Diagnostics
- Salivary Gland Tumors Diagnosis and Treatment
- Interconnection Networks and Systems
- Lung Cancer Treatments and Mutations
- Greenhouse Technology and Climate Control
- Advanced Memory and Neural Computing
- Nitric Oxide and Endothelin Effects
- Digital and Cyber Forensics
- Advanced Optical Network Technologies
- Neurosurgical Procedures and Complications
- Vascular Malformations Diagnosis and Treatment
- Psoriasis: Treatment and Pathogenesis
- Microbial Inactivation Methods
- Adipokines, Inflammation, and Metabolic Diseases
- Cancer, Lipids, and Metabolism
- Supply Chain and Inventory Management
Capital Medical University
2020-2025
Tianjin International Joint Academy of Biomedicine
2023-2025
Nankai University
2023-2025
The University of Texas MD Anderson Cancer Center
2021-2025
Northwest A&F University
2024-2025
Beijing Jiaotong University
2025
Wuhan Institute of Bioengineering
2024-2025
Sun Yat-sen University
2017-2025
Beijing Friendship Hospital
2025
Beijing Tian Tan Hospital
2020-2024
Patient-derived xenograft (PDX) models are widely used in cancer research. To investigate the genomic fidelity of non-small cell lung PDX models, we established 48 from 22 patients enrolled TRACERx study. Multi-region tumor sampling increased successful engraftment and most were histologically similar to their parent tumor. Whole-exome sequencing enabled comparison tumors provide an adapted mouse reference genome for improved removal NOD scid gamma (NSG) mouse-derived reads data. model...
Polylactic acid (PLA) surgical suture can be absorbed by human body. In order to avoid site infections (SSIs), the drug is usually loaded on PLA suture, and then release directly wound. Because different types of wounds heal at times, it needed control rate consistent wound healing time. Two biopolymers, polyglycolide (PGA) polycaprolactone (PCL), were selected as carrier ciprofloxacin (CPFX) drug, CPFX-PCL/PGA was coated suture. The degradation drug-carrier controlled adjusting proportion...
Background: Surgical treatment demonstrated a reduction in mortality among patients suffering from severe spontaneous intracerebral hemorrhage (SSICH). However, which SSICH could benefit surgical was unclear. This study aimed to establish and validate decision tree (DT) model help determine treatment. Materials methods: prospective, multicenter cohort were analyzed retrospectively. The primary outcome the incidence of neurological poor (modified Rankin scale as 4-6) on 180 th day...
Quantification of cytokine is indispensable to elucidate the mechanism immune regulation at molecular level, thereby contributing diagnosis and treatment several diseases. Here, we aimed determine effect detection method storage conditions specimens on quantification levels. We used four vacuum blood collection tubes containing EDTA, heparin, clot activator, gel compared changes in expression levels 14 cytokines serum plasma samples different temperatures durations using AimPlex flow...
Abstract Background Intracranial aneurysm is a leading cause of subarachnoid hemorrhage and affects approximately 7% the Chinese population, posing significant public health concern. Due to lack national cohort unruptured intracranial aneurysms (UIAs) in China, optimal surgical management for UIAs remain insufficiently explored. Methods The China Treatment Trial Unruptured Aneurysm (ChTUIA) national, prospective, observational, multi-center registry study designed identify population....
The progress of local environmental regulation in protected agriculture is sluggish, particularly concerning the air supply, which poses a significant obstacle to greenhouse energy-saving research. This study establishes test platform for supply winter and summer by integrating design principles from human settlements’ bag models with crop growth requirements. By utilizing direct fresh conditioning system specific areas within greenhouse, non-uniform ventilation created. Research has...
Adenoid cystic carcinoma (ACC) with NOTCH-activating mutations presents a clinical challenge due to its poor prognosis. NOTCH inhibitors have emerged as potential therapy for ACC patients activation. This study aimed evaluate the efficacy of in this patient population. A retrospective analysis was conducted on metastatic harboring pathway activation, who received at MD Anderson Cancer Center. included AL101, gamma-secretase inhibitor, and brontictuzumab, an antibody targeting NOTCH1....
Background: The three commercial Enterovirus 71 (EV71) inactivated vaccines which have effectively controlled the EV71 pandemic currently rely on inherent variable in vivo potency methods for batch release. To align with 3R (Replacement, Reduction, Refinement) principles and enhance quality control, this study referred to WHO guidelines European Pharmacopoeia develop vitro relative (IVRP) methods. Methods: Working standards tracing phase 3 clinical were established. Manufacture-specific IVRP...
Rationale: Tumor cells are ideal candidates for developing cancer vaccines due to their antigenic profiles, yet existing whole-cell lack efficacy. This study aimed develop a novel vaccine platform that combines immunogenicity, structural integrity, and tumor-targeting capabilities. Methods: We created "Magnetic Sculpture-like (MASK) Cells" by treating tumor with high-concentration FeCl3, inducing rapid morphological fixation without traditional chemical crosslinking. MASK were characterized...