A5111109777- Intracranial Aneurysms: Treatment and Complications
- Vascular Malformations Diagnosis and Treatment
- Traumatic Brain Injury and Neurovascular Disturbances
- Intracerebral and Subarachnoid Hemorrhage Research
- Neurosurgical Procedures and Complications
- Inflammatory Biomarkers in Disease Prognosis
- Adipokines, Inflammation, and Metabolic Diseases
- Moyamoya disease diagnosis and treatment
- Ion Channels and Receptors
- Nutrition and Health in Aging
- Telomeres, Telomerase, and Senescence
- Ion channel regulation and function
- Acute Ischemic Stroke Management
- Coronary Interventions and Diagnostics
- Anesthesia and Neurotoxicity Research
- Viral gastroenteritis research and epidemiology
- Respiratory viral infections research
- Hydrogen's biological and therapeutic effects
- Pain Management and Treatment
- Erythrocyte Function and Pathophysiology
- Inflammasome and immune disorders
- Cancer Cells and Metastasis
- Takotsubo Cardiomyopathy and Associated Phenomena
- Medical and Biological Ozone Research
- Acute Myocardial Infarction Research
Beijing Tian Tan Hospital
2022-2025
Capital Medical University
2022-2025
National Clinical Research Center for Digestive Diseases
2023-2025
Dalian Medical University
2025
Chongqing Medical University
2025
Second Affiliated Hospital of Chongqing Medical University
2025
Beijing Institute of Neurosurgery
2024
Second Hospital of Tianjin Medical University
2023-2024
Chinese Institute for Brain Research
2022-2024
Tianjin Medical University
2023-2024
Abstract Background Inflammation and maladaptive immune mechanisms have been substantiated as integral components in the critical pathological processes of injury cascade ischemic stroke (IS). This study aimed to explore associations between six systemic inflammatory indices IS a Chinese population. Methods was case-control based on retrospective review electronic medical records from two hospitals Shandong Province, China. Systemic indices, including inflammation response index (SIRI),...
Recently, the systemic immune inflammatory response index (SIIRI), a novel and expanded marker, has been an independent predictor of lesion severity in patients with acute coronary syndrome (ACS). However, its predictive role initially diagnosed artery disease (CAD) remains to be explored.We evaluated 959 CAD undergoing initial intervention. Each patient had laboratory measurements, including blood cell counts, taken after admission before interventional treatment. The primary endpoint was...
Hypopharyngeal squamous cell carcinoma (HPSCC) has the worst prognosis among all head-and-neck cancers, and treatment options are limited. Tumor microenvironment (TME) analysis can help identify new therapeutic targets combined strategies.Six primary HPSCC tissues two adjacent normal mucosae from six treatment-naïve patients with were analyzed using scRNA-seq. Cell types curated in detail, ecosystemic landscapes mapped, cell-cell interactions inferred. Key results validated The Cancer Genome...
Early systemic inflammatory changes are increasingly recognized as factors influencing outcomes after aneurysmal subarachnoid hemorrhage (aSAH). Systemic inflammation response index (SIRI), an biomarker, was thought to be associated with adverse in many other diseases. However, aSAH, research on SIRI remains limited. Thus, our objective investigate the association between and poor long-term functional while evaluating mediating role of in-hospital complications this association.
Abstract Background Intracranial aneurysm is a leading cause of subarachnoid hemorrhage and affects approximately 7% the Chinese population, posing significant public health concern. Due to lack national cohort unruptured intracranial aneurysms (UIAs) in China, optimal surgical management for UIAs remain insufficiently explored. Methods The China Treatment Trial Unruptured Aneurysm (ChTUIA) national, prospective, observational, multi-center registry study designed identify population....
Background: Previous studies report that intraoperative hypotension worsens outcomes after aneurysmal subarachnoid hemorrhage (aSAH). However, the hypotensive harm threshold for major adverse cardiovascular events (MACE) remains unclear. Methods: The authors included aSAH patients who had general anesthesia clipping/coiling. MACE were defined by a composite of acute myocardial injury, infarction, and other complications identified electrocardiogram echocardiography. initially used logistic...
Mechanosensitive ion channels are a class of membrane-integrated proteins that convert externalmechanical forces, including stretching, pressure, gravity, and osmotic pressure changes, some which can be caused by pathogen invasion, into electrical chemical signals transmitted to the cytoplasm. In recent years, with identification many these channels, their roles in initiation progression diseases have been gradually revealed. Multiple studies shown mechanosensitive regulate proliferation,...
This study aimed to investigate the natural history of re-rupture in ruptured brain arteriovenous malformations (AVMs) and provide comprehensive insights into its associated factors prevention.
Abstract Objective The aim of this study is to explore whether preoperative hemoglobin levels could serve as a prospective biomarker for early brain injury in patients with aneurysmal subarachnoid hemorrhage (aSAH). This investigation seeks discern its association postoperative complications and unfavorable clinical outcomes. Methods We conducted comprehensive analysis data derived from the LongTeam registry, including aSAH diagnosed between January 2015 September 2021. These were stratified...
OBJECTIVE Reducing the incidence of delayed postoperative hemorrhage (DPH) is one challenges in surgical treatment patients with brain arteriovenous malformations (bAVMs). This study aimed to identify several risk factors for DPH after bAVM resection and evaluate impact these bAVMs. METHODS The authors retrospectively reviewed consecutive bAVMs who underwent microsurgical between August 2011 September 2021. Patients were divided into either group or non-DPH based on whether they experienced...
Rupture is the most life-threatening manifestation of cerebral AVMs. This study aimed to explore hemodynamic mechanism AVM rupture. We introduced a new quantitative DSA parameter that can reflect degree intranidal blood stasis, called lesion-filling index.
Abstract Background Aneurysmal subarachnoid hemorrhage (aSAH) is a life-threatening neurosurgical emergency with high mortality rate. Delayed cerebral ischemia (DCI) and vasospasm (CVS) are delayed products of early brain injury (EBI), which may constitute the principal determinant an unfavorable patient prognosis. Consequently, mitigation DCI CVS assumes paramount significance in pursuit enhanced outcomes. However, except for oral nimodipine, there no effective therapy available current...
This study aimed to evaluate six novel lymphocyte-based inflammatory markers (neutrophil-lymphocyte ratio, monocyte-lymphocyte platelet-lymphocyte ratio [PLR], systemic immune inflammation index [SII], response index, and [SIIRI]) in patients with newly diagnosed coronary artery disease [CAD].
Objective This study initiated a preliminary computational fluid dynamics (CFD)-based to investigate the relationship between quantitative hemodynamics of arteriovenous malformation (AVM) draining veins and rupture. Methods The AVM were generated from computed tomography angiography (CTA)-based steady-state CFD models. Morphological hemodynamic parameters compared ruptured unruptured groups. boundary conditions drainage vein obtained digital subtraction (QDSA). divided into 15 consecutive...
To explore the underlying causality between leukocyte telomere length (LTL) and four gastrointestinal diseases, we designed a two-sample bidirectional Mendelian randomization study.Two-sample (MR) was used to genetic LTL including irritable bowel syndrome (IBS), gastroesophageal reflux disease (GERD), ulcers (GUD), nonalcoholic fatty liver (NAFLD). We utilized inverse-variance weighted (IVW) as primary method for MR analysis. Supplementary analyses were conducted using methods such MR-Egger...
INTRODUCTION: The dilemma between natural rupture risk and adverse outcomes of intervention is major concern for patients with unruptured arteriovenous malformations (AVMs). existing score AVM includes factors that are controversial lacks prospective validation. METHODS: This prognostic study developed a prediction model derived from single-center cohort (derivation cohort) validated in multicenter external validation conservative treatment cohort. Patients were recruited nationwide...
<title>Abstract</title> Objective: This study initiated a preliminary computational fluid dynamics (CFD)-based to investigate the relationship between quantitative hemodynamics of arteriovenous malformation (AVM) draining veins and rupture. Methods: The AVM were generated from computed tomography angiography (CTA)-based steady-state CFD models. Morphological hemodynamic parameters compared ruptured unruptured groups. boundary conditions drainage vein obtained digital subtraction (QDSA)....
An electrocardiogram (ECG) was used to determine the type of acute myocardial infarction (MI) and locate culprit vessel. Inferior wall (IWMI) patients with right coronary artery (RCA) as vessel may have a worse clinical prognosis than left circumflex (LCx). We aimed develop new, simple, accurate scoring system localize RCA.
To compare the effectiveness of radiomic features based on